Core Center for Chemical Senses

化学感官核心中心

基本信息

批准号：
8681194
负责人：
Robert F. Margolskee
金额：
$ 50.84万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2016-06-30
项目状态：
已结题

项目摘要

The Monell Chemical Senses Center, founded in 1968, is the world's first and only multidisciplinary institute devoted entirely to basic research in the chemical senses and produces extensive research within the NIDCD mission area. Two of Monell's greatest strengths are the breadth of approaches brought to bear on problems in the chemical senses, and the effective interdisciplinary collaborations that are fostered at the Monell Center. In this P30 grant application for a Core Center in the chemical senses, four Research Cores with distinct areas of technical expertise highly relevant to the chemical senses are proposed: 1. Histology, 2. Genotyping, 3. Molecular Biology, and 4. Phenotyping. In addition, an Administrative Core will support the Research Cores in their mission to enhance the research of users in our Research Base of thirteen R01 grants in the NIDCD mission area. Dr. Liquan Huang will lead the Histology Core, building on his expertise in the visualization of proteins in taste receptor cells. The Genotyping Core will be led by Dr. Danielle Reed, who has over twenty years of training and experience with genotyping and gene mapping. Dr. Bedrich Mosinger, an expert in molecular biology and in constructing transgenic mouse models, is the Director of the Molecular Biology Core. Dr. Alexander Bachmanov will run the Phenotyping Core; he is well-known for his ability to phenotype mice and rats for traits relevant to the chemical senses. The Director of the Administrative Core is Dr. Robert Margolskee, who through his expertise in the research areas of all four Research Cores and his administrative experience is uniquely qualified to serve as PI of this Core Center grant. Together these Cores will serve the Research Base at Monell and by contributing to innovative research in the chemical senses further the mission of NIDCD to understand taste, smell and the common chemical sense in order to improve human health and well-being.

莫内尔化学感官中心成立于 1968 年，是世界上第一个也是唯一一个完全致力于化学感官基础研究的多学科研究所，并在 NIDCD 任务领域进行广泛的研究。莫内尔的两个最大优势是解决化学意义上的问题的广泛方法，以及莫内尔中心促进的有效的跨学科合作。在化学意义核心中心的 P30 拨款申请中，提出了四个与化学意义高度相关的技术专业知识不同领域的研究核心：1. 组织学、2. 基因分型、3. 分子生物学和 4. 表型分析。此外，行政核心将支持研究核心履行其使命，以加强我们在 NIDCD 任务领域的 13 个 R01 拨款研究基地中的用户研究。黄立泉博士将利用他在味觉受体细胞中蛋白质可视化方面的专业知识，领导组织学核心。基因分型核心将由 Danielle Reed 博士领导，她在基因分型和基因图谱方面拥有二十多年的培训和经验。 Bedrich Mosinger 博士是分子生物学和转基因小鼠模型构建方面的专家，也是分子生物学核心的主任。 Alexander Bachmanov 博士将负责表型分析核心；他因能够对小鼠和大鼠的化学感官相关特征进行表型分析而闻名。行政核心主任是 Robert Margolskee 博士，凭借其在所有四个研究核心研究领域的专业知识以及他的行政经验，他具有独特的资格担任该核心中心资助的 PI。这些核心将共同服务于莫内尔研究基地，并通过促进化学感官的创新研究，进一步推进 NIDCD 的使命，即了解味觉、嗅觉和常见化学感官，从而改善人类健康和福祉。