Core Center for Chemical Senses

化学感官核心中心

基本信息

批准号：
8294729
负责人：
Robert F. Margolskee
金额：
$ 39.55万
依托单位：
MONELL CHEMICAL SENSES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-05 至 2016-06-30
项目状态：
已结题

项目摘要

The Monell Chemical Senses Center, founded in 1968, is the world's first and only multidisciplinary institute devoted entirely to basic research in the chemical senses and produces extensive research within the NIDCD mission area. Two of Monell's greatest strengths are the breadth of approaches brought to bear on problems in the chemical senses, and the effective interdisciplinary collaborations that are fostered at the Monell Center. In this P30 grant application for a Core Center in the chemical senses, four Research Cores with distinct areas of technical expertise highly relevant to the chemical senses are proposed: 1. Histology, 2. Genotyping, 3. Molecular Biology, and 4. Phenotyping. In addition, an Administrative Core will support the Research Cores in their mission to enhance the research of users in our Research Base of thirteen R01 grants in the NIDCD mission area. Dr. Liquan Huang will lead the Histology Core, building on his expertise in the visualization of proteins in taste receptor cells. The Genotyping Core will be led by Dr. Danielle Reed, who has over twenty years of training and experience with genotyping and gene mapping. Dr. Bedrich Mosinger, an expert in molecular biology and in constructing transgenic mouse models, is the Director of the Molecular Biology Core. Dr. Alexander Bachmanov will run the Phenotyping Core; he is well-known for his ability to phenotype mice and rats for traits relevant to the chemical senses. The Director of the Administrative Core is Dr. Robert Margolskee, who through his expertise in the research areas of all four Research Cores and his administrative experience is uniquely qualified to serve as PI of this Core Center grant. Together these Cores will serve the Research Base at Monell and by contributing to innovative research in the chemical senses further the mission of NIDCD to understand taste, smell and the common chemical sense in order to improve human health and well-being.

Monell化学感官中心成立于1968年，是世界上第一个也是唯一的多学科研究所，完全致力于化学感官的基础研究，并在NIDCD任务领域进行了广泛的研究。 Monell的两个最大优势是在化学感官中带来的问题以及在Monell Center培养的有效跨学科合作所带来的范围。在化学感官中为核心中心的P30授予申请中，提出了具有与化学感官高度相关的技术专长领域的四个研究核心：1。组织学，2。基因分型，3。分子生物学和4个。表型。此外，行政核心将支持研究核心的使命，以增强我们在NIDCD任务领域的13 R01补助金的研究基础中的用户研究。 Liquan Huang博士将领导组织学核心，基于他在味觉受体细胞中可视化蛋白质的专业知识的基础上。基因分型核心将由丹妮尔·里德（Danielle Reed）博士领导，他在基因分型和基因映射方面拥有二十年的培训和经验。 Bedrich Mosinger博士是分子生物学和构建转基因小鼠模型的专家，是分子生物学核心的主任。亚历山大·巴赫曼诺夫（Alexander Bachmanov）博士将运行表型核心；他以与化学感官相关的特征表征小鼠和大鼠表型小鼠和大鼠的能力而闻名。行政核心的主任是罗伯特·玛格尔斯基（Robert Margolskee）博士，他通过他在所有四个研究核心的研究领域的专业知识，他的行政经验具有独特的资格，可以作为该核心中心赠款的PI。这些核心将共同为Monell的研究基础服务，并通过在化学方面为创新研究做出贡献，进一步了解NIDCD的使命，以了解味道，气味和常见的化学意义，以改善人类健康和福祉。