CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8365053
• 负责人: HENRY N GINSBERG
• 金额: $ 45.91万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8365053
• 关键词: Acquired Immunodeficiency Syndrome; Award; Clinical Sciences; Research; Research Infrastructure; Translational Research

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of clinical and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches; a novel, 2-phase inter- disciplinary pilot award program that has already captured several NIH grants; a Website for all service request that also has a faculty directory that facilitates collaborative research; 5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications; collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services; successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols; opening of the Columbia Community Partnership for Health center, one-half mile from CUMC. as a home for community-based organizations and community- based participatory research; launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing independent funding; and transformation of the "old" GCRC core laboratory into a campus-wide biomarkers core serving T1, T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept of the CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed for T2 and T3 clinical researchers; (2) Capitalize on CUMC's outstanding T1 discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for comparative effectiveness research. PUBLIC HEALTH RELEVANCE (provided by applicant): The Clinical and Translational Science Award (CTSA) allow Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.

该子项目代表了 CTSA 资金百分比的估计 被用于广泛的研究领域（艾滋病研究、儿科研究或 临床试验）。 列出的总成本只是 CTSA 金额的估计值 该研究领域的基础设施，而不是直接资助 NCRR 向子项目或子项目人员提供的补助金。 描述（由申请人提供）：哥伦比亚大学医学中心 (CUMC) CTSA 和欧文临床与转化研究所 (IICTR) 利用教师在 10 个关键资源方面的专业知识和承诺，在实现转变医疗文化的目标方面取得了显着进展CUMC 的临床和转化 (C/T) 研究。例子包括：使用跨学科方法的新颖项目；一个新颖的、分两阶段的跨学科试点奖励计划，该计划已经获得了 NIH 的多项资助；一个满足所有服务请求的网站，还有一个促进合作研究的教员名录；为 600 多名研究人员提供 5 小时免费咨询，获得 33 项 NIH 资助和 106 篇出版物；几个 CUMC 监管小组之间的合作显着改善了合同签订、IRB 审批时间和道德教育/咨询服务； ICU 和 ED 中的卫星研究设施成功发射，导致 50 名新研究人员执行 30 项新方案；距 CUMC 半英里的哥伦比亚健康社区合作伙伴中心开业。作为社区组织和社区参与性研究的所在地；推出新的 POR 硕士学位、现有 T32 项目中新颖的一年证书课程以及出色的 KL2 项目，其中 9 名学者已获得独立资助；将“旧”GCRC 核心实验室改造为校园范围内的生物标志物核心，为 T1、T2 和 T3 研究人员提供服务。自始至终，我们的跟踪和评估小组都为未来的方向提供了重要的帮助。最重要的是，我们已经验证了 CTSA 的概念，并正在改变 CUMC 的研究文化。未来 4 年，在每年近 400 万美元的机构支持下，我们将在此基础上再接再厉， (1) 扩大我们为 T2 和 T3 临床研究人员开发的资源和基础设施； (2) 通过将现有资源和研究人员更紧密地整合到我们的 CTSA 中，充分利用 CUMC 杰出的 T1 发现研究社区。 (3) 通过与 NYPH 门诊护理网络和社区组织合作开发比较有效性研究平台，改善我们社区的健康。 公共卫生相关性（由申请人提供）：临床和转化科学奖 (CTSA) 允许哥伦比亚大学支持新颖的项目，其目标是加速将实验室的科学发现转化为新疗法。 CTSA 将确保这些新疗法被执业医生和社区成员接受，以便我们能够开始显着改善我们社区和国家的健康。