UCLA-CDU CFAR

加州大学洛杉矶分校-CDU CFAR

• 批准号: 10458369
• 负责人: Judith S. Currier
• 金额: $ 300.56万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-08 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458369
• 关键词: AIDS prevention; AIDS/HIV problem; Accreditation; Acquired Immunodeficiency Syndrome; Address; Animal Model; Area; Award; Behavioral; Biological Assay; California; Clinic; Clinical; Clinical Informatics; Clinical Laboratory Improvement Amendments; Clinical Research; Clinical Sciences; Clinics and Hospitals; Collaborations; Communities; County; Data; Development; Disease; Disease remission; Ensure; Epidemic; Equipment; Faculty; Funding; Goals; Grant; HIV; HIV Infections; Healthcare Systems; Incubators; Infection prevention; Infrastructure; Institutes; Institution; Interdisciplinary Study; Laboratories; Leadership; Link; Los Angeles; Medical center; Mentors; Mission; Morbidity - disease rate; Neighborhoods; Participant; Pathogenesis; Persons; Pilot Projects; Policies; Population; Procedures; Provider; Public Health Informatics; Registries; Regulation; Research; Research Activity; Research Personnel; Resources; Sampling; Science; Scientist; Services; Shapes; Site; Structure; Talents; Techniques; Training; Training Activity; Translational Research; United States National Institutes of Health; Universities; Ursidae Family; base; behavioral study; biobank; career; community based participatory research; community based research; community engagement; cost effective; design; gene therapy; health equity; humanized mouse; meetings; member; metropolitan; multidisciplinary; next generation; prevent; programs; recruit; research study; social; substance use; success; symposium; working group

Overall: Project Summary/Abstract: This application is a resubmission for a new CFAR that is a partnership between UCLA and CDU. Our overarching goal is to create a nimble multi-institutional infrastructure that promotes equity and will connect and support investigators affiliated with both institutions to advance critical HIV science. The UCLA-CDU CFAR will strengthen and amplify the impact of existing research activities and launch new partnerships across Los Angeles and globally through our focus on three themes: we will STOP HIV by preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission). This grant will fund AIDS-related activities and programs conducted by investigators at UCLA, CDU and our Affiliated institutions, which include Harbor-UCLA Medical Center in Torrance; the UCLA CARE Clinic and the VA Greater Los Angeles Healthcare System in Westwood; the UCLA Vine Street Clinic in West Hollywood; and the Drew CARES, the CDU PUSH coalition and the MLK OASIS Clinic at CDU. These facilities are at ground zero for the AIDS epidemic in Los Angeles County, with the greatest number of persons living with HIV residing in the neighborhoods directly served by our hospitals and clinics. In addition to the facilities and programs based in Los Angeles, researchers at UCLA and CDU have extensive partnerships with HIV programs around the globe that are aimed at building global capacity. The CFAR will enhance our ability to deliver research at the interface of community by reaching communities most in need and by bringing to bear the talent of CDU and UCLA researchers to address problems from a multi-disciplinary perspective while mentoring the next generation who better reflect the diversity of communities being served. The overall organization of the UCLA-CDU CFAR will allow us to efficiently and effectively manage AIDS research activities by harnessing the diverse expertise in our CFAR, and by including linkages to community- based clinician investigators and communities. The action plan for the first year of requested support includes 6 cores and 1 scientific working group (SWG): the Administrative Core, Developmental Core, Centralized Laboratory Support Core, Humanized Mouse and Gene Therapy Core, Community Engagement and Clinical Informatics Core, Clinical Science Core, and a Translational Research in Substance Use SWG. RELEVANCE: Research into the pathogenesis, treatment and social aspects of HIV disease is required to end the epidemic. The UCLA-CDU CFAR seeks to catalyze and expand HIV research by providing the infrastructure to connect, support and enhance the capacity of investigators affiliated with UCLA and CDU. This will be accomplished by stimulating the conduct and dissemination of high impact multidisciplinary research aimed at the NIH priorities of preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission).

总体而言：项目摘要/摘要：此申请是对新 CFAR 的重新提交，该新 CFAR 是合作伙伴关系 加州大学洛杉矶分校和基民盟之间。我们的首要目标是创建一个灵活的多机构基础设施 促进公平，并将联系和支持两个机构附属的调查人员，以推进关键的艾滋病毒 科学。加州大学洛杉矶分校-基民盟 CFAR 将加强和扩大现有研究活动的影响，并启动 通过我们对三个主题的关注，在洛杉矶和全球范围内建立新的伙伴关系：我们将通过以下方式阻止艾滋病毒： 预防新的艾滋病毒感染（预防），降低艾滋病毒感染者的发病率（治疗）以及 制定根除策略（无 ART 缓解）。这笔赠款将资助与艾滋病相关的活动 由 UCLA、CDU 和我们的附属机构（包括 Harbor-UCLA）的研究人员开展的项目 托伦斯医疗中心； UCLA CARE 诊所和 VA 大洛杉矶医疗系统 韦斯特伍德；西好莱坞的加州大学洛杉矶分校藤街诊所；和德鲁关心、基民盟推动联盟和 CDU 的 MLK OASIS 诊所。这些设施是洛杉矶县艾滋病流行的归零地， 最多数量的艾滋病毒感染者居住在我们医院直接服务的社区 和诊所。除了位于洛杉矶的设施和项目外，加州大学洛杉矶分校和基民盟的研究人员还 与全球旨在建设全球能力的艾滋病毒项目建立广泛的伙伴关系。恒虚警 将通过接触最有需要的社区来增强我们在社区界面提供研究的能力 并通过发挥基民盟和加州大学洛杉矶分校研究人员的才能来解决多学科问题 的观点，同时指导下一代更好地反映所服务社区的多样性。 UCLA-CDU CFAR 的整体组织将使我们能够高效、有效地管理艾滋病 通过利用我们的 CFAR 中的多样化专业知识以及包括与社区的联系来开展研究活动 临床医生、研究人员和社区。请求支持第一年的行动计划包括 6 个核心和 1 个科学工作组 (SWG)：行政核心、发展核心、集中核心 实验室支持核心、人源化小鼠和基因治疗核心、社区参与和临床 信息学核心、临床科学核心和物质使用转化研究 SWG。关联： 要结束这种流行病，需要对艾滋病毒疾病的发病机制、治疗和社会方面进行研究。 加州大学洛杉矶分校-基民盟 CFAR 旨在通过提供基础设施来促进和扩大艾滋病毒研究， 支持和增强加州大学洛杉矶分校和基民盟附属调查人员的能力。这将通过以下方式完成 促进针对 NIH 优先事项的高影响力多学科研究的开展和传播 预防新的艾滋病毒感染（预防）、降低艾滋病毒感染者的发病率（治疗）和 制定根除策略（无 ART 缓解）。