Pilot Demonstration

试点示范

基本信息

批准号：
8929489
负责人：
Michael Benatar
金额：
$ 6.31万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-30 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8929489
关键词：
Advanced Development Alzheimer&apos s Disease Amyotrophic Lateral Sclerosis Biological Biological Assay Biological Markers Biology Blood Blood specimen Cerebrospinal Fluid Cerebrospinal Fluid Proteins Clinical Research Collection Communities Cross-Sectional Studies Data Development Diagnosis Disease Disease Progression Electromyography Evaluation Extramural Activities Functional RNA Functional disorder Funding Future Genetic Risk Goals Grant Laboratories Magnetic Resonance Imaging Monitor Motor Motor Neurons Myography NGFR Protein Neurologic Examination Patients Pilot Projects Process Publishing RNA Request for Applications Research Research Design Research Infrastructure Research Personnel Research Project Grants Resources Saliva Sample Size Sampling Science Scientist Staging Suggestion Testing Therapeutic Agents Urine Validation Work base cohort deep sequencing diagnostic accuracy disorder risk electric impedance extracellular follow-up improved member neuroimaging novel outcome forecast programs repository response success therapeutic development urinary

项目摘要

PILOT/DEMONSTRATION PROJECTS The primary purpose of the CREATE RDCRC pilot/demonstration research program is to promote biomarker discovery and validation for ALS and related disorders through a small research grant program that funds studies of potential biomarkers during their early stages of development. Priority is given to projects with the most promising clinical research potential. The activities of the CREATE Consortium - longitudinal evaluation of patients with familial and sporadic disease, collection of deep phenotypic data, and the establishment of a repository of biological samples (blood, urine, cerebrospinal fluid) that has been annotated clinically in a detailed manner - are all expected to enhance and facilitate biomarker discovery through the pilot/ demonstration research program. The first pilot/demonstration project will focus on early development of a cerebrospinal fluid biomarker for ALS. Potential projects in subsequent years include development of a urinary biomarker of disease progression and a neuroimaging marker of the imbalance between cortical inhibition and excitability. The CREATE RDCRC will utilize a "request for applications" on an annual basis, to solicit applications and to select the most promising project for funding.

试点/示范项目 CREATE RDCRC 试点/示范研究计划的主要目的是通过一项小型研究资助计划来促进 ALS 和相关疾病的生物标志物发现和验证，该计划资助潜在生物标志物早期开发阶段的研究。优先考虑具有最有前途的临床研究潜力的项目。 CREATE联盟的活动——对家族性和散发性疾病患者进行纵向评估，收集深层表型数据，并建立经过详细临床注释的生物样本（血液、尿液、脑脊液）存储库——预计所有这些都将通过试点/示范研究计划来加强和促进生物标志物的发现。第一个试点/示范项目将重点关注 ALS 脑脊液生物标志物的早期开发。随后几年的潜在项目包括开发疾病进展的尿液生物标志物和皮质抑制与兴奋性之间不平衡的神经影像标志物。 CREATE RDCRC 将每年利用“申请请求”来征求申请并选择最有希望获得资助的项目。