Intranasal Oxytocin: A Neuropharmacological Intervention for Maternal Neglect?

鼻内催产素：针对母亲忽视的神经药理学干预措施？

基本信息

批准号：
8467000
负责人：
Lane Strathearn
金额：
$ 23.61万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-15 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8467000
关键词：
Accounting Adult Affect Amygdaloid structure Animals Anxiety Area Behavior Behavior Therapy Behavioral Biological Blinded Brain Brain region Child Abuse and Neglect Child Behavior Child Development Classification Corpus striatum structure Cross-Over Studies Cues Devices Disease Dopamine Dorsal Effectiveness Empathy Enrollment Epigenetic Process Equilibrium Eye Face Figs - dietary Functional Magnetic Resonance Imaging Future Hormones Human Hypothalamic structure Image Individual Differences Infant Interpersonal Relations Intervention Intervention Studies Interview Investigation Lead Link MRI Scans Maternal Behavior Measures Medial Modeling Mother-Child Relations Mothers Motor output Neurobiology Neuropeptides Neurosecretory Systems Oxytocin Pathway interactions Pattern Peripheral Pharmaceutical Preparations Phase Placebo Control Placebos Play Population Prefrontal Cortex Primary Prevention Principal Investigator Procedures Production Public Health Randomized Randomized Controlled Trials Recovery Research Research Design Resources Rewards Rodent Rodent Model Secure Security Sensory Social Behavior Social Environment Substantia nigra structure System Techniques Technology Testing Time Trust United States United States Dept. of Health and Human Services United States National Institutes of Health Ventral Striatum Ventral Tegmental Area Videotape base caregiving child neglect emotional neglect gaze indexing neglect neuroimaging offspring psychosocial public health relevance response reward processing social

项目摘要

DESCRIPTION (provided by applicant): Neglect is the most common but least studied form of child maltreatment, with some of the most serious long- term consequences for child development. Behavioral and psychosocial interventions are frequently ineffective, possibly due to inherent biological differences in mothers who neglect their offspring. Rodent and more recent human research has demonstrated the importance of the neuropeptide, oxytocin, in facilitating social and maternal behaviors. The Principal Investigator was recently demonstrated that mothers with an insecure/dismissing pattern of adult attachment, as determined from the Adult Attachment Interview, show reduced brain reward system activation and impaired oxytocin production when engaging with their own infant. This proposal aims to determine whether intranasal oxytocin enhances maternal brain and behavioral responses to infant cues, as a possible neuropharmacological intervention for maternal neglect. One hundred and twenty first time mothers and their term infants will be enrolled to participate in a randomized, placebo- controlled crossover study of intranasal oxytocin. Functional MRI brain responses to infant face cues will be measured, as well as videotaped behavioral responses of mothers during a free-play interaction and a modified still-face procedure. Eye tracking technology will also be utilized in the scanner to determine whether oxytocin alters patterns of eye gaze when mothers view infant face images. It is hypothesized that intranasal oxytocin, compared with placebo, will result in increased activation of mesocorticolimbic dopamine reward regions in the brain, in response to own vs. unknown infant face cues. This response will also be associated with enhanced infant eye gaze in the oxytocin treatment condition. Mothers who receive intranasal oxytocin will also score higher on an overall measure of maternal sensitivity during a free play interaction (the CARE-Index), and will display more emotionally contingent responses with their infant during a modified still-face procedure. Interaction effects will be explored between treatment condition, mother's attachment classification and, in fMRI sessions, infant face affect (happy vs. sad). Finally, it is hypothesized that brain reward activation will be associated with other indirect measures of emotional neglect in mothers, including maternal sensitivity, eye gaze when viewing sad infant faces, and the contingency of maternal responses to infant cues during the modified still-face procedure. We anticipate that these results will be the basis for future randomized, controlled intervention studies of intranasal oxytocin in maternal neglect.

描述（由申请人提供）：忽视是最常见但研究最少的儿童虐待形式，对儿童发育造成一些最严重的长期后果。行为和社会心理干预常常无效，这可能是由于忽视后代的母亲固有的生物学差异所致。啮齿动物和最近的人类研究已经证明了神经肽催产素在促进社会和母性行为方面的重要性。首席研究员最近证明，根据成人依恋访谈确定，具有不安全/排斥成人依恋模式的母亲在与自己的婴儿交往时，大脑奖励系统的激活程度降低，催产素的产生受损。该提案旨在确定鼻内催产素是否增强母亲大脑和对婴儿线索的行为反应，作为母亲忽视的一种可能的神经药理学干预措施。一百二十名首次当妈妈的人和她们的足月婴儿将被招募参加一项随机、安慰剂对照的鼻内催产素交叉研究。将测量功能性核磁共振大脑对婴儿面部线索的反应，以及录制的母亲在自由玩耍互动和修改后的静止面部程序期间的行为反应。扫描仪还将利用眼动追踪技术来确定当母亲观看婴儿面部图像时催产素是否会改变眼睛注视模式。据推测，与安慰剂相比，鼻内催产素将导致大脑中皮质边缘多巴胺奖励区域的激活增加，以响应自己与未知的婴儿面部线索。这种反应也与催产素治疗条件下婴儿眼睛凝视的增强有关。接受鼻内催产素的母亲在自由玩耍互动期间对母亲敏感性的总体测量（CARE-Index）也会得分更高，并且在改良的静止面部手术中会与婴儿表现出更多的情绪反应。将探讨治疗条件、母亲依恋分类以及功能磁共振成像会议中婴儿面部表情（快乐与悲伤）之间的相互作用。最后，假设大脑奖励激活与母亲情绪忽视的其他间接测量相关，包括母亲敏感性、观看悲伤婴儿面孔时的目光凝视，以及在改良的静止面部程序中母亲对婴儿提示的偶然反应。我们预计这些结果将成为未来鼻内催产素对母亲忽视的随机、对照干预研究的基础。