Cardiovascular and Metabolic Risk Factors Associated with Short Sleep Duration

与短睡眠时间相关的心血管和代谢危险因素

• 批准号: 8527838
• 负责人: Michael A Grandner
• 金额: $ 16.08万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8527838
• 关键词: Accounting; Address; Affect; Architecture; Behavior Therapy; Behavioral; Biological Markers; Blood; Blood Pressure; Body mass index; Cardiovascular system; Cholesterol; Circadian Rhythms; Data; Databases; Detection; Development; Effectiveness; Epidemiologic Studies; Epidemiology; Exhibits; Future; Goals; Health; Health Psychology; Heart; High Density Lipoproteins; Home environment; Hour; Impairment; Individual; Inflammatory; Insulin Resistance; Interleukin-6; Intervention; Intrinsic Sleep Disorders; K-Series Research Career Programs; Lead; Leptin; Lipoproteins; Literature; Low-Density Lipoproteins; Master' s Degree; Measures; Mentors; Mentorship; Metabolic; Motor Vehicles; OGTT; Obesity; Outcome; Outcome Study; Patient Self-Report; Performance; Phase; Phenotype; Physiologic pulse; Physiology; Polysomnography; Population; Psychomotor Performance; Recruitment Activity; Relative (related person); Reporting; Research; Resistance; Risk; Risk Factors; Sampling; Sampling Studies; Schedule; Seminal; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep disturbances; Staging; Subgroup; Surveys; Testing; Time; Training; Translational Research; Triglycerides; Work; actigraphy; arterial tonometry; base; blood glucose regulation; cardiovascular risk factor; cohort; deprivation; design; diaries; experience; ghrelin; glucose tolerance; high risk; indexing; inflammatory marker; insulin sensitivity; low density lipoprotein triglyceride; obesity risk; programs; research study; response; screening; standardize measure; vigilance

DESCRIPTION (provided by applicant): There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two phases.report short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects' survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.

描述（由申请人提供）：来自流行病学和实验研究的越来越多的证据表明，除了这些较大的文献之外，还有一些研究直接、更深入地调查了短睡眠现象，但这些研究并没有解决与健康相关的问题结果。研究：本次 K 奖中提出的研究旨在成为更大的研究计划的第一步，该计划将有助于在流行病学和实验领域之间架起桥梁。这最终将实现（1）识别有睡眠不足不良影响风险的个体，（2）开发行为干预措施，旨在改善睡眠不足对心脏代谢的不利影响，以及（3）检测真实的个体睡眠时间短的人以及使他们能够抵抗睡眠时间短的不良影响的品质。拟议的研究利用大规模调查 (n=1200) 招募 60 名受试者（40 名短时睡眠者和 20 名正常睡眠者）分两个阶段进行评估。报告称短睡眠存在导致许多负面心血管和代谢健康结果的风险。这些研究在评估样本枕木短时存在局限性。 具有开创性和开创性，而流行病学睡眠者短期聚合和评估项目）（单一非标准用途通常研究可能非常异质的样本。实验研究虽然受到高度控制，并且由同质睡眠填充，但偏向于相似更多，但它表明了操纵的结果第一阶段是一项为期两周的家庭研究，该研究将用于前瞻性地证实受试者对睡眠持续时间的调查反应，以筛选睡眠不足的样本。睡眠呼吸障碍，并收集血压数据，这是一项为期 3 晚的实验室研究，将用于收集睡眠连续性和睡眠结构（通过多导睡眠图）、困倦（通过多次睡眠）的标准化测量。潜伏期测试）、精神运动表现（通过精神运动警戒任务）、主动脉葡萄糖稳态（通过口服葡萄糖耐量测试）和生物标志物，包括致动脉粥样硬化脂蛋白（即高密度脂蛋白和高密度脂蛋白） LDL)、IL-6、CRP、瘦素和生长素释放肽。基于实验室的数据将用于 (1) 确定短时睡眠者和正常睡眠者在睡眠、困倦/表现和心脏代谢功能的客观测量方面是否存在差异，以及 (2) 探索（初步）短时睡眠中的亚组是否存在差异。睡眠者队列解释了睡眠持续时间与健康之间的关联。脉搏波速度（通过动脉张力测量），培训：K23 的这一部分包括使申请人能够开发拟议的研究计划所需的教学和指导经验。该培训计划以申请人的健康心理学背景为基础，为他提供必要的心血管和代谢生理学培训，以解决睡眠不足的行为表型是否以及如何与负面健康结果相关。教学方法包括常规的一对一指导、课程作业、基于实验室的实践以及完成转化研究硕士学位课程。