Cardiovascular and Metabolic Risk Factors Associated with Short Sleep Duration

与短睡眠时间相关的心血管和代谢危险因素

• 批准号: 9204167
• 负责人: Michael A Grandner
• 金额: $ 14.29万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9204167
• 关键词: Cardiovascular; Metabolic; Risk; Factors; Associated

DESCRIPTION (provided by applicant): There is growing evidence from epidemiological and experimental studies that individuals who Apart from these larger literatures, there are a few studies that have investigated the short sleeper phenomenon directly and more intensively, but these do not address health-related outcomes. Research: The study proposed within this K-Award is intended to be a first step in a larger program of research that will serve to bridge between the epidemiologic and experimental domains. This will ultimately allow for (1) Identification of individuals that are at risk for the ill effects of short sleep, (2) Development f behavioral interventions aimed at ameliorating adverse cardiometabolic effects of insufficient sleep, and (3) Detection of individuals that are true short sleepers and the qualities that make them resistant to the ill effects of short sleep. The proposed study utilizes a large-scale survey (n=1200) to recruit 60 subjects (40 short and 20 normal duration sleepers) to be assessed in two phases.report short sleep are at risk for a number of negative cardiovascular and metabolic health outcomes. These studies, in evaluated samples sleeper short The limitations. have seminal, and groundbreaking while epidemiological sleeper short aggregate and assessments item) (single nonstandard use often studies samples that are likely very heterogeneous. The experimental studies, while highly controlled and populated by homogenous sleep partial to similar more is that state a produce that manipulations engage samples, deprivation than naturally-occurring short sleep. Phase 1, a 2-week home-based study, will be used to prospectively corroborate subjects' survey responses regarding sleep duration, to screen for sleep-disordered breathing, and to gather blood pressure data. Phase-2, a 3-night, in-lab study, will be used to gather standardized measures of sleep continuity and sleep architecture (via polysomnography), sleepiness (via a Multiple Sleep Latency Test), psychomotor performance (via the Psychomotor Vigilance Task), aortic glucose homeostasis (via an Oral Glucose Tolerance Test) and biomarkers including atherogenic lipoproteins (i.e., HDL and LDL), IL-6, CRP, leptin and ghrelin. The lab-based data will be used to (1) Determine whether short and normal duration sleepers differ on objective measures of sleep, sleepiness/performance, and cardiometabolic function, and (2) Explore (in a preliminary way) whether subgroups within the short sleeper cohort account for the association between sleep duration and health. pulse wave velocity (via arterial tonometry), Training: This component of the K23 is comprised of the didactic and mentored experiences required to enable the applicant to develop the proposed program of research. The training plan builds upon the applicant's background in Health Psychology and provides him the necessary training in cardiovascular and metabolic physiology to address if and how the behavioral phenotype of short sleep is associated with negative health outcomes. The pedagogic approach includes routine one-on-one mentorship, course work, lab-based practica, and completion of a Masters degree program in Translational Research.

描述（由申请人提供）：从流行病学和实验研究中越来越多的证据表明，除了这些较大的文献外，还有一些研究直接和更深入地研究了短暂的卧铺现象，但这些研究并不能解决与健康相关的结果。研究：在此K-award中提出的研究旨在成为更大的研究计划中的第一步，该计划将在流行病学和实验领域之间桥接。这最终将允许（1）识别有可能遭受短睡眠不良影响的个体，（2）开发f行为干预措施旨在减轻睡眠不足的不良心脏代谢效应，以及（3）检测真正短暂睡眠者及其使他们对短睡眠不良影响的质量。拟议的研究利用一项大规模调查（n = 1200）来招募60名受试者（40名短期和20个正常持续时间卧铺），以分为两个阶段进行评估。报告短暂睡眠有可能发生许多负面的心血管和代谢健康结果。这些研究，在评估样品中，卧铺的限制短。 具有在流行病学睡眠者短时间和评估项目的同时具有开创性和突破性的项目）（单个非标准使用经常研究样本可能是非常异构的样本。实验性研究虽然高度控制和受到同质睡眠的高度控制和填充，而同质睡眠则与类似的相似性相似，这是一种与自然校正的矫正性相比，剥夺的剥夺，是一个基于较短的睡眠。有关睡眠持续时间的反应，以筛选睡眠状态的呼吸以及收集血压数据，将使用3晚，单位研究，以收集标准化的睡眠连续性和睡眠结构（通过polymnography）的标准化度量以及包括动脉粥样硬化脂蛋白（即HDL和LDL），IL-6，CRP，Leptin和Ghrelin的生物标志物。基于实验室的数据将用于（1）确定短期和正常持续时间的睡眠者在睡眠，嗜睡/表现和心脏代谢功能的客观度量方面是否有所不同，以及（2）探索（以初步方式）探索短睡眠者队列中的亚组是否在睡眠持续时间和健康之间的关联中是否存在。脉冲波速度（通过动脉渗透学），训练：K23的这一组成部分由使申请人能够制定拟议的研究计划所需的教学和有指导的经验。培训计划以申请人的健康心理学背景为基础，并为他提供了心血管和代谢生理学的必要培训，以解决短睡眠的行为表型与不良健康结果的相关性。教学方法包括常规的一对一指导，课程工作，基于实验室的实践以及完成转化研究硕士学位课程。