PIB PET Scanning in Speech and Language Based Dementias

PIB PET 扫描治疗言语和语言痴呆症

• 批准号: 8212043
• 负责人: Keith A Josephs
• 金额: $ 33.42万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8212043
• 关键词: 6-hydroxybenzothiazole; Activities of Daily Living; Algorithms; Alzheimer' s Disease; Amyloid beta-Protein; Amyloid deposition; Anomia; Area; Atrophic; Autopsy; Behavioral; Biological Markers; Brain; Center for Translational Science Activities; Clinic; Clinical; Comprehension; Data; Dementia; Deposition; Detection; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Doctor of Philosophy; Equipment; Foundations; Frontotemporal Lobar Degenerations; Functional disorder; Future; Glucose; Goals; Gold; Grant; Image; Imaging Techniques; Impairment; Joints; Laboratories; Language; Language Disorders; Lead; Limb structure; Magnetic Resonance Imaging; Manuscripts; Medical center; Memory; Memory Loss; Methods; Minority; Movement Disorders; Neurodegenerative Disorders; Neurologic; Neurology; Neuropsychological Tests; Neurosciences; Nuclear; Parietal Lobe; Parkinsonian Disorders; Pathology; Patients; Peer Review; Pittsburgh Compound-B; Positioning Attribute; Positron-Emission Tomography; Primary Progressive Aphasia; Principal Investigator; Prize; Production; Proteins; Publications; Publishing; Radiology Specialty; Recruitment Activity; Research; Research Personnel; Rest; Scanning; Scientist; Severities; Solid; Solutions; Specialist; Speech; Speech Disorders; Speech Pathologist; Speech Pathology; Techniques; Testing; Training; United States; Visuospatial; Work; amyloid imaging; aphasic; base; beta amyloid pathology; cost effective; diagnosis evaluation; executive function; expectation; experience; frontal lobe; gray matter; in vivo; innovation; nervous system disorder; neuropsychological; public health relevance; radiologist; tomography

DESCRIPTION (provided by applicant): Speech and language based dementias (SLDs) (often referred to as primary progressive aphasias) are neurodegenerative diseases in which speech and language impairments are the most salient features of the disease and explain deficits in activities of daily living. These dementias may or may not be associated with the deposition of the protein beta-amyloid in the brain, which until recently could only be determined at postmortem. Since new treatments will likely target underlying abnormal proteins, accurate prediction of the pathology underlying the SLDs is critical. The recent development of amyloid imaging compounds now allows the in vivo detection of beta-amyloid in the brain. Unfortunately, amyloid imaging compounds are expensive and are not accessible to most medical centers throughout the United States. The objectives of the studies outlined in this proposal are to identify clinical, neuropsychological or non-amyloid imaging biomarkers that are readily available, relatively inexpensive, and non-invasive, that will allow the prediction of beta-amyloid in the brain in patients with SLDs. To accomplish this goal we will be using the amyloid imaging compound 11C Pittsburgh Compound B (PiB) as the gold standard for the detection of beta-amyloid. The methods will include detailed neurological, speech and language and neuropsychological assessments, magnetic resonance imaging, and [18-F]-fluoro-deoxy-glucose (FDG) and PiB PET scanning. Associations between PiB positive scanning and these techniques will be sought. One of the most salient features of the speech and language assessments will be the determination of the presence and severity of apraxia of speech and its association with beta-amyloid deposition. This study will be carried out at the Mayo Clinic in Rochester, MN, which evaluates a large number of patients with SLDs annually. The study also intends to recruit minorities with SLDs which are currently understudied. The methods will be performed by a team of world renowned scientists including dementia, movement disorders and speech pathology specialists, radiology researchers, a nuclear medicine scientist, neuropsychologists, and biostatisticians. The long term goal of our research is to develop a cost effective algorithmic approach to the evaluation and diagnosis of patients with SLDs. PUBLIC HEALTH RELEVANCE: This study will identify ways to determine whether Alzheimer's disease is the underlying cause of a patient's progressive speech and language problem. In addition, the study aims to identify the most cost effective way to do this so that more patients, including minorities, can be given an accurate diagnosis. Results from this grant will ultimately lead to better targeted future treatments for patients with problems with speech and language.

描述（由申请人提供）：基于言语和语言的痴呆症 (SLD)（通常称为原发性进行性失语症）是神经退行性疾病，其中言语和语言障碍是该疾病最显着的特征，并解释了日常生活活动的缺陷。这些痴呆症可能与大脑中β-淀粉样蛋白的沉积有关，也可能无关，而直到最近，这种沉积只能在死后才能确定。由于新的治疗方法可能会针对潜在的异常蛋白质，因此准确预测 SLD 潜在的病理学至关重要。最近开发的淀粉样蛋白成像化合物现在可以体内检测大脑中的β-淀粉样蛋白。不幸的是，淀粉样蛋白成像化合物价格昂贵，并且全美大多数医疗中心都无法获得。本提案中概述的研究目标是确定临床、神经心理学或非淀粉样蛋白成像生物标志物，这些生物标志物易于获得、相对便宜且非侵入性，从而可以预测 SLD 患者大脑中的 β-淀粉样蛋白。为了实现这一目标，我们将使用淀粉样蛋白成像化合物 11C 匹兹堡化合物 B (PiB) 作为检测 β-淀粉样蛋白的金标准。这些方法将包括详细的神经学、言语和语言以及神经心理学评估、磁共振成像以及[18-F]-氟脱氧葡萄糖（FDG）和PiB PET扫描。将寻求 PiB 阳性扫描与这些技术之间的关联。言语和语言评估的最显着特征之一是确定言语失用的存在和严重程度及其与β-淀粉样蛋白沉积的关系。这项研究将在明尼苏达州罗切斯特市的梅奥诊所进行，该诊所每年都会评估大量 SLD 患者。该研究还打算招募目前尚未得到充分研究的具有 SLD 的少数群体。这些方法将由世界知名科学家团队执行，其中包括痴呆症、运动障碍和言语病理学专家、放射学研究人员、核医学科学家、神经心理学家和生物统计学家。我们研究的长期目标是开发一种具有成本效益的算法方法来评估和诊断 SLD 患者。 公共健康相关性：这项研究将确定确定阿尔茨海默病是否是患者进行性言语和语言问题的根本原因的方法。此外，该研究旨在确定最具成本效益的方法，以便为更多患者（包括少数族裔）提供准确的诊断。这笔赠款的结果最终将为患有言语和语言问题的患者带来更有针对性的未来治疗。