Biobehavioral Studies of Obesity, Weight loss and Recidivism

肥胖、减肥和累犯的生物行为研究

• 批准号: 7734341
• 负责人: Monica Skarulis
• 金额: $ 105.52万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7734341
• 关键词: Address; Adipose tissue; Adopted; Air; Anaerobic Threshold; Arts; Atherosclerosis; Behavior; Behavioral; Biopsy; Blood specimen; Body Composition; Body Weight decreased; Brain; Cardiac; Cardiac Output; Cardiopulmonary; Chronic; Circadian Rhythms; Class; Clinical Research; Cognitive; Condition; DNA; Data; Degenerative polyarthritis; Development; Diabetes Mellitus; Disease; Dual-Energy X-Ray Absorptiometry; Eating Behavior; Economics; Endocrine Glands; Energy Intake; Energy Metabolism; Enrollment; Environment; Equipment; Evaluation; Exercise; Exercise stress test; Facilities and Administrative Costs; Failure; Fatty acid glycerol esters; Follow-Up Studies; Food; Gene Expression; Genes; Genetic; Genomics; Health; Heart Rate; Hormonal; Hormones; Human; Individual; Inflammation; Inflammatory; Inpatients; Institutes; Intervention; Laboratories; Life Expectancy; Life Style; Liver diseases; Macronutrients Nutrition; Malignant Neoplasms; Measures; Mechanics; Medical; Mental Depression; Metabolic; Methodology; Micronutrients; Modification; Morbid Obesity; Morbidity - disease rate; Motion; Muscle; Natural History; Nerve Degeneration; Non-Insulin-Dependent Diabetes Mellitus; Nutritionist; Obesity; Operative Surgical Procedures; Overweight; Oxidative Stress; Participant; Patient Care; Patients; Patients' Rooms; Pattern; Phenotype; Physical activity; Physicians; Physiology; Play; Plethysmography; Population; Process; Range; Rate; Records; Relapse; Reproducibility; Research; Rest; Risk Factors; Role; Sampling; Signal Transduction; Site; Skeletal Muscle; Sleep; Sleep Apnea Syndromes; Socioeconomic Status; Strategic Planning; Stroke; System; Techniques; Telemetry; Temperature; Testing; Therapeutic; Time; Tissues; Treatment Protocols; United States; United States National Institutes of Health; Urinary Incontinence; Variant; Weight; bariatric surgery; biobehavior; clinical phenotype; cognitive function; day; design; detection of nutrient; electric impedance; energy balance; experience; fitness; hypertensive heart disease; interest; intravenous glucose tolerance test; metabolic abnormality assessment; multidisciplinary; neurocognitive test; neuropsychological; pandemic disease; patient safety; peripheral blood; psychologic; recidivism; respiratory; response; sensor; success; trait; validation studies; weight loss intervention

The Metabolic Clinical Research Unit (MRCU) and the Phenotyping Laboratory opened in January 2007 and are the primary sites where this research is conducted. The MCRU is comprised of ten private inpatient rooms modified to accommodate the needs and safety of patients with extreme obesity (class III). See http://www2.niddk.nih.gov/Research/ClinicalResearch/MCRU/. Dynamic metabolic testing (frequently sampled intravenous glucose tolerance test and mixed meal test), diurnal testing (hormones and temperature), sleep studies, resting energy expenditure, heart rate variability studies, muscle and fat biopsies, neurocognitive testing and psychological assessments are performed in the patient's room. An exercise testing room equipped with a full metabolic cart, treadmill, an upright and a reclining cycle ergometer, is used to perform gross mechanical efficiency, anaerobic threshold, VO2 Max, maximal power (peak Watt), resting and maximal heart rate, resting and exercise-induced cardiac output (cardiac impedance). In subjects unable to use the cycle ergometer or treadmill, the Cooper test is performed using portable exercise equipment. Nutritionist evaluate participant's seven day food records for caloric intake and micro- and macronutrient composition. The Phenotyping Laboratory contains three rapid response respiratory chambers for the assessment of total energy expenditure, sleeping metabolic rate and other components of energy expenditure. The chambers are equipped with a treadmill, telemetry, motion sensors and an isolette system for procuring blood samples. Body composition is measured by dual energy X-ray absorptiometry (DEXA) with a table rated to 450 lbs, air displacement plethysmography (ADP) and bioelectric impedence. As part of this natural history study, baseline phenotypic data is currently being obtained in subjects of normal weight, overweight and class I, II and III obesity. Subjects are invited to return for yearly evaluations. Validation studies to assess the dynamic range and reproducibility of the equipment including the cart and room calorimeters, DEXA and ADP and exercise equipment have been performed. A bank of skeletal muscle, fat and peripheral blood for genomic DNA is being created on the extensively phenotyped subjects. Participants are provided a summary of clinically useful results that they can share with their physicians in planning weight loss strategies. Subjects participating in weight loss interventions such as bariatric surgery are targeted for follow-up studies to assess changes in parameters of interest.

代谢临床研究部门（MRCU）和表型实验室于2007年1月开放，是进行这项研究的主要地点。 MCRU由修改的十个私人住院室组成，以适应极端肥胖症患者的需求和安全性（III类）。请参阅http://www2.niddk.nih.gov/research/clinicalresearch/mcru/。 动态代谢测试（经常采样静脉葡萄糖耐受性测试和混合餐测试），昼夜测试（激素和温度），睡眠研究，静息能量消耗，心率变异性研究，肌肉和脂肪体验，神经认知测试和心理评估在患者的房间中进行。 锻炼测试室配备了完整的代谢推车，跑步机，直立的和斜切的周期测量表，用于执行粗大的机械效率，厌氧阈值，Max Max，Maxmimal Power（峰值瓦特），休息和最大心脏和最大的心脏速率，静息和运动诱发的心脏输出（心脏障碍）。 在无法使用周期测量计或跑步机的受试者中，使用便携式运动器材进行库珀测试。 营养学家评估了参与者的七日食品记录，以进行热量摄入以及微量营养素组成。 表型实验室包含三个快速反应呼吸道，用于评估总能量消耗，睡眠代谢率和能量消耗的其他组成部分。 腔室配备了跑步机，遥测，运动传感器和用于采购血液样本的隔离系统。 通过双能X射线吸收仪（DEXA）测量身体成分，其表格为450磅，空气位移散布（ADP）和生物电性障碍。 作为这项自然史研究的一部分，目前正在为正常体重，超重和I类，II和III肥胖的受试者获得基线表型数据。邀请受试者返回年度评估。已经进行了验证研究，以评估设备的动态范围和可重复性，包括购物车和房间量热量计，DEXA和ADP以及运动设备。 在广泛的表型受试者上，正在创建一堆用于基因组DNA的骨骼肌，脂肪和外周血。 为参与者提供了临床上有用的结果的摘要，他们可以与医生在计划减肥策略方面共享。 参与减肥干预措施（例如减肥手术）的受试者是针对后续研究，以评估感兴趣参数的变化。