Biobehavioral Studies of Obesity, Weight loss and Recidivism

肥胖、减肥和累犯的生物行为研究

基本信息

批准号：
7967799
负责人：
Monica Skarulis
金额：
$ 121.62万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7967799
关键词：
Address Adipose tissue Adopted Arts Atherosclerosis Behavior Behavioral Blood specimen Body Composition Body Weight decreased Brain Cardiopulmonary Chronic Circadian Rhythms Clinical Research Cognitive Collaborations DEXA DNA Data Degenerative polyarthritis Development Diabetes Mellitus Disease Eating Eating Behavior Endocrine Glands Energy Metabolism Enrollment Environment Equipment Evaluation Exercise Facilities and Administrative Costs Failure Fatty acid glycerol esters Follow-Up Studies Gene Expression Genes Genetic Genomics Genotype Health Hormonal Hormones Human Individual Inflammatory Inpatients Institutes Intervention Laboratories Life Expectancy Life Style Liver diseases Malignant Neoplasms Measures Medical Metabolic Methodology Modification Morbid Obesity Morbidity - disease rate Natural History Nerve Degeneration Non-Insulin-Dependent Diabetes Mellitus Obesity Operative Surgical Procedures Overweight Oxidative Stress Participant Patient Care Patient Self-Report Patients Pattern Phenotype Physical activity Physicians Physiology Play Population Process Relapse Reproducibility Research Research Personnel Risk Factors Role Signal Transduction Site Skeletal Muscle Sleep Sleep Apnea Syndromes Socioeconomic Status Strategic Planning Stroke Techniques Testing Therapeutic Time Tissues Treatment Protocols United States United States National Institutes of Health Urinary Incontinence Variant Weight bariatric surgery biobehavior clinical phenotype cognitive function depression design detection of nutrient economic impact energy balance experience fitness hypertensive heart disease inflammatory marker metabolic abnormality assessment multidisciplinary neuropsychological nutritional epidemiology pandemic disease patient safety peripheral blood recidivism success tool trait validation studies weight loss intervention

项目摘要

The Metabolic Clinical Research Unit (MRCU) and the Phenotyping Laboratory opened in January 2007 and are the primary sites where this research is conducted. The MCRU is comprised of ten private inpatient rooms modified to accommodate the needs and safety of patients with extreme obesity (class III). See http://www2.niddk.nih.gov/Research/ClinicalResearch/MCRU/. As part of this natural history study, baseline phenotypic data is obtained in subjects of normal weight, overweight and class I, II and III obesity. Participants are provided a summary of clinically useful results that they can share with their physicians in planning weight loss strategies and are invited to return for yearly evaluations. Validation studies to assess the dynamic range and reproducibility of the equipment including the cart and room calorimeters, DEXA and ADP and exercise equipment have been performed. A bank of skeletal muscle, fat and peripheral blood for genomic DNA is being created on the extensively phenotyped subjects and is shared with investigators across the NIH campus. Subject accrual to target inclusion of patients with genotypes associated with weight dysregulation or metabolic disturbance has begun. Subjects participating in weight loss interventions such as bariatric surgery are targeted for follow-up studies to assess changes in body composition and energy expenditure. A collaboration with the NCI Nutritional Epidemiology Branch aims to validate new tools for studying self report of exercise and food intake.

代谢临床研究部门（MRCU）和表型实验室于2007年1月开放，是进行这项研究的主要地点。 MCRU由修改的十个私人住院室组成，以适应极端肥胖症患者的需求和安全性（III类）。请参阅http://www2.niddk.nih.gov/research/clinicalresearch/mcru/。作为这项自然史研究的一部分，基线表型数据是在正常体重，超重和I类，II和III级肥胖的受试者中获得的。为参与者提供了临床上有用的结果的摘要，他们可以与医生在计划减肥策略方面共享，并邀请返回年度评估。已经进行了验证研究，以评估设备的动态范围和可重复性，包括购物车和房间量热量计，DEXA和ADP以及运动设备。在广泛的表型受试者上创建了一堆用于基因组DNA的骨骼肌，脂肪和外周血，并与NIH校园的研究人员共享。受试者的靶向纳入与体重失调或代谢障碍相关的基因型患者的受试者已经开始。参与减肥干预措施（例如减肥手术）的受试者是针对性研究，以评估身体成分和能量消耗的变化。与NCI营养流行病学分支机构的合作旨在验证研究运动和食物摄入自我报告的新工具。