Biobehavioral Studies of Obesity, Weight loss and Recidivism

肥胖、减肥和累犯的生物行为研究

• 批准号: 7593798
• 负责人: Monica Skarulis
• 金额: $ 30.7万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7593798
• 关键词: Address; Adipose tissue; Adopted; Air; Anaerobic Threshold; Arts; Atherosclerosis; Behavior; Behavioral; Biopsy; Blood specimen; Body Composition; Body Weight decreased; Brain; Cardiac; Cardiac Output; Cardiopulmonary; Chronic; Circadian Rhythms; Class; Clinical Research; Cognitive; Condition; DNA; Data; Degenerative polyarthritis; Development; Diabetes Mellitus; Disease; Dual-Energy X-Ray Absorptiometry; Eating Behavior; Economics; Endocrine Glands; Energy Intake; Energy Metabolism; Enrollment; Environment; Equipment; Evaluation; Exercise; Exercise stress test; Facilities and Administrative Costs; Failure; Fatty acid glycerol esters; Follow-Up Studies; Food; Gene Expression; Genes; Genetic; Genomics; Health; Heart Rate; Hormonal; Hormones; Human; Individual; Inflammation; Inflammatory; Inpatients; Institutes; Intervention; Laboratories; Life Expectancy; Life Style; Liver diseases; Macronutrients Nutrition; Malignant Neoplasms; Measures; Mechanics; Medical; Mental Depression; Metabolic; Methodology; Micronutrients; Modification; Morbid Obesity; Morbidity - disease rate; Motion; Muscle; Natural History; Nerve Degeneration; Non-Insulin-Dependent Diabetes Mellitus; Nutritionist; Obesity; Operative Surgical Procedures; Overweight; Oxidative Stress; Participant; Patient Care; Patients; Patients' Rooms; Pattern; Phenotype; Physical activity; Physicians; Physiology; Play; Plethysmography; Population; Process; Range; Rate; Records; Relapse; Reproducibility; Research; Rest; Risk Factors; Role; Sampling; Signal Transduction; Site; Skeletal Muscle; Sleep; Sleep Apnea Syndromes; Socioeconomic Status; Strategic Planning; Stroke; System; Techniques; Telemetry; Temperature; Testing; Therapeutic; Time; Tissues; Treatment Protocols; United States; United States National Institutes of Health; Urinary Incontinence; Variant; Weight; bariatric surgery; biobehavior; clinical phenotype; cognitive function; day; design; detection of nutrient; electric impedance; energy balance; experience; fitness; hypertensive heart disease; interest; intravenous glucose tolerance test; metabolic abnormality assessment; multidisciplinary; neurocognitive test; neuropsychological; pandemic disease; patient safety; peripheral blood; psychologic; recidivism; respiratory; response; sensor; success; trait; validation studies; weight loss intervention

The Metabolic Clinical Research Unit (MRCU) and the Phenotyping Laboratory opened in January 2007 and are the primary sites where this research is conducted. The MCRU is comprised of ten private inpatient rooms modified to accommodate the needs and safety of patients with extreme obesity (class III). See http://www2.niddk.nih.gov/Research/ClinicalResearch/MCRU/. Dynamic metabolic testing (frequently sampled intravenous glucose tolerance test and mixed meal test), diurnal testing (hormones and temperature), sleep studies, resting energy expenditure, heart rate variability studies, muscle and fat biopsies, neurocognitive testing and psychological assessments are performed in the patient's room. An exercise testing room equipped with a full metabolic cart, treadmill, an upright and a reclining cycle ergometer, is used to perform gross mechanical efficiency, anaerobic threshold, VO2 Max, maximal power (peak Watt), resting and maximal heart rate, resting and exercise-induced cardiac output (cardiac impedance). In subjects unable to use the cycle ergometer or treadmill, the Cooper test is performed using portable exercise equipment. Nutritionist evaluate participant's seven day food records for caloric intake and micro- and macronutrient composition. The Phenotyping Laboratory contains three rapid response respiratory chambers for the assessment of total energy expenditure, sleeping metabolic rate and other components of energy expenditure. The chambers are equipped with a treadmill, telemetry, motion sensors and an isolette system for procuring blood samples. Body composition is measured by dual energy X-ray absorptiometry (DEXA) with a table rated to 450 lbs, air displacement plethysmography (ADP) and bioelectric impedence. As part of this natural history study, baseline phenotypic data is currently being obtained in subjects of normal weight, overweight and class I, II and III obesity. Subjects are invited to return for yearly evaluations. Validation studies to assess the dynamic range and reproducibility of the equipment including the cart and room calorimeters, DEXA and ADP and exercise equipment have been performed. A bank of skeletal muscle, fat and peripheral blood for genomic DNA is being created on the extensively phenotyped subjects. Participants are provided a summary of clinically useful results that they can share with their physicians in planning weight loss strategies. Subjects participating in weight loss interventions such as bariatric surgery are targeted for follow-up studies to assess changes in parameters of interest.

代谢临床研究中心 (MRCU) 和表型实验室于 2007 年 1 月成立，是开展此项研究的主要场所。 MCRU 由 10 间经过改造的私人住院病房组成，以满足极度肥胖（III 级）患者的需求和安全。请参阅http://www2.niddk.nih.gov/Research/ClinicalResearch/MCRU/。 动态代谢测试（频繁采样的静脉葡萄糖耐量测试和混合膳食测试）、昼间测试（激素和体温）、睡眠研究、静息能量消耗、心率变异性研究、肌肉和脂肪活检、神经认知测试和心理评估均在病人的房间。 运动测试室配有全代谢车、跑步机、直立式和斜躺式自行车测力计，用于测试总机械效率、无氧阈值、最大摄氧量、最大功率（峰值瓦特）、静息和最大心率、静息和心率运动引起的心输出量（心阻抗）。 对于无法使用自行车测力计或跑步机的受试者，使用便携式运动设备进行库珀测试。 营养师评估参与者的 7 天食物记录，了解热量摄入以及微量和大量营养素的组成。 表型实验室包含三个快速反应呼吸室，用于评估总能量消耗、睡眠代谢率和能量消耗的其他组成部分。 这些室配备了跑步机、遥测、运动传感器和用于采集血液样本的 isolette 系统。 身体成分通过双能 X 射线吸收测定法 (DEXA)、额定值为 450 磅的工作台、排气体积描记法 (ADP) 和生物电阻抗来测量。 作为这项自然历史研究的一部分，目前正在正常体重、超重以及 I、II 和 III 级肥胖受试者中获得基线表型数据。邀请受试者返回进行年度评估。已经进行了验证研究，以评估设备的动态范围和再现性，包括推车和室内热量计、DEXA 和 ADP 以及运动设备。 正在针对广泛表型的受试者创建骨骼肌、脂肪和外周血基因组 DNA 库。 向参与者提供临床有用结果的摘要，他们可以与医生分享这些结果以规划减肥策略。 参与减肥干预措施（例如减肥手术）的受试者将成为后续研究的目标，以评估感兴趣参数的变化。