Cancer Epidemiology Cohort in Male Health Professionals

男性健康专业人员中的癌症流行病学队列

• 批准号: 8298342
• 负责人: Walter C. Willett
• 金额: $ 240.11万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-21 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8298342
• 关键词: Accounting; Age; Age-Years; Archives; Biological; Biological Markers; Blood; Blood specimen; Cancer Etiology; Cells; Cessation of life; Cohort Studies; Collaborations; Collection; Colon; Colonic Neoplasms; Colorectal; Colorectal Cancer; Colorectal Neoplasms; DNA; Data; Data Quality; Databases; Diagnosis; Diagnostic; Diet; Dietary Assessment; Dietary Component; Enrollment; Erythrocytes; Exposure to; Female; Food; Frequencies; Funding; Gene Expression; Genetic Predisposition to Disease; Germ Lines; Goals; Hand; Health Professional; Incidence; Laboratories; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mediating; Medical; Medical Records; Messenger RNA; Methods; Methylation; Morbidity - disease rate; Nail plate; Nurses' Health Study; Paper; Participant; Pathology; Pathology Report; Pharmaceutical Preparations; Phase; Physical activity; Plasma; Policies; Positioning Attribute; Procedures; Prostate; Prostatic Neoplasms; Publications; Publishing; Quality Control; Quality of life; Questionnaires; Recurrence; Reproducibility; Research Activity; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Risk; Risk Factors; Role; Sampling; Smoking; Structure of base of prostate; Structure of nail of toe; Support System; Survival Analysis; System; Systems Analysis; Time; TimeLine; Tissue Banks; Tissue Microarray; Tissues; Tumor Tissue; U-Series Cooperative Agreements; Update; Vitamin D; Weight; biobank; cancer diagnosis; cancer epidemiology; carcinogenesis; cohort; data management; data sharing; design; diet and cancer; evidence base; follow-up; genome-wide; indexing; male; male health; member; men; modifiable risk; mortality; novel; programs; tissue processing; tumor; validation studies

DESCRIPTION (provided by applicant): We propose to continue the follow-up of the Health Professional's Follow-up Study, a cancer epidemiology cohort of 51,529 men enrolled in 1986 when they were 40 to 75 years of age. The cohort is currently supported as part of a Program Project; consistent with NCI policy, we are now applying for support of the infrastructure through a cooperative agreement. The cohort includes a biorespository with DNA samples from 35,000 participants, plasma from 18,000, nails from 33,000, and tumor tissue from approximately 70% of incident colon, prostate, and other important cancers. In this cohort, smoking, weight, medication use, and medical diagnoses have been updated every 2 years and information on diet and physical activity has been updated every four years. Much other valuable exposure information is collected. Follow-up of the cohort has been approximately 94% complete at each of the 2-year follow-up cycles and ascertainment of deaths is at least 98% complete. This cohort has been highly productive; 341 papers have been published during the current funding cycle or are in press. Novel findings include the identification of modifiable risk factors that account for one third of aggressive prostate cancer; strong evidence based on plasma levels, germ line DNA, and gene expression in tumor tissue that vitamin D is importantly involved in risk of death from prostate cancer; and roles of specific diet factors and physical activity after the diagnosis f colorectal and prostate cancer in survival. This cohort has also contributed to 19 cancer-related consortia during this funding period and has an active data sharing component. The HPFS is unique as the largest cancer cohort in men with many repeated measures of exposure over more than two decades, which provides a powerful view of realistic latent periods for carcinogenesis and the opportunity to examine both pre-and post-diagnosis determinants of survival from cancer. Because of the massive, detailed data and biological samples already in hand, the nearly complete ascertainment of incident cancers with high rates of tissue acquisition, and the entry of the younger members of the cohort into the age of maximal cancer incidence, this cohort will be even more fruitful scientifically during the next five years.

描述（由申请人提供）：我们建议继续对卫生专业人员的后续研究进行随访，这是1986年40至75岁的51,529名癌症流行病学队列。目前，该队列是计划项目的一部分；与NCI政策一致，我们现在通过合作协议申请支持基​​础设施的支持。该队列包括来自35,000名参与者的DNA样品，从18,000名的血浆，33,000的指甲以及大约70％的入射结肠，前列腺和其他重要癌症的肿瘤组织。在此队列中，每两年更新一次吸烟，体重，药物使用和医疗诊断，并且每四年更新饮食和体育锻炼的信息。收集了许多其他有价值的曝光信息。在两年的随访周期中的每个周期中的每个周期中，该队列的随访已完成约94％，而死亡的确定至少为98％。这个队列的生产力很高。在当前的融资周期中已发表了341篇论文，或者在印刷中发表。新发现包括识别可修改的风险因素 侵略性前列腺癌的三分之一；基于血浆水平，生殖系DNA和基因表达的有力证据表明，维生素D重要地参与了前列腺癌死亡的风险。诊断后的特定饮食因素和身体活动的作用F结直肠癌和前列腺癌在生存中。在这一资金期间，该队列还为19个与癌症相关的财团做出了贡献，并具有积极的数据共享部分。 HPF是独特的，是男性最大的癌症队列，在超过二十年中，有许多重复暴露的措施，这为癌变的现实潜在时期提供了有力的看法，并有机会检查癌症生存前和诊断后的诊断决定因素。由于已经掌握了大量的，详细的数据和生物样品，因此几乎完全确定了具有较高组织习得率的发生癌症，并且在接下来的五年中，该队列的年轻成员进入最大癌症的年龄，该队列将在科学上更加富有成果。