Validity of Diet and Activity Measures in Women

女性饮食和活动措施的有效性

• 批准号: 7816062
• 负责人: Walter C. Willett
• 金额: $ 625.13万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7816062
• 关键词: Animals; Basal metabolic rate; Biological Markers; Blood specimen; Calibration; Cancer Etiology; Carotenoids; Chronic Disease; Cohort Studies; Collection; Confidence Intervals; Country; Data; Databases; Diet; Diet Records; Dietary Assessment; Dietary Fats; Dietary intake; Disease; Eating; Energy Intake; Energy Metabolism; Evaluation; Fasting; Fatty Acids; Folate; Food; Frequencies; Funding; Future; Gender; Height; Hour; Incidence; Intake; Investigation; Label; Lipids; Literature; Malignant Neoplasms; Measurement; Measures; Methods; Monitor; Morphologic artifacts; Motion; Nitrogen; Nurses' Health Study; Nutrient; Online Systems; Paper; Participant; Patient Self-Report; Physical activity; Plasma; Potassium; Potential Energy; Prospective Studies; Proteins; Public Health; Publishing; Questionnaires; Records; Relative (related person); Relative Risks; Request for Proposals; Research Design; Research Infrastructure; Research Personnel; Self-Administered; Series; Sodium; Stimulus; Structure; System; Time; Training; Validation; Variant; Water; Weight; Woman; Work; base; cohort; design; diet and cancer; disorder risk; instrument; malignant breast neoplasm; men; parent grant; public health relevance; response; time interval; urinary; validation studies; Animals; Basal metabolic rate; Biological Markers; Blood specimen; Calibration; Cancer Etiology; Carotenoids; Chronic Disease; Cohort Studies; Collection; Confidence Intervals; Country; Data; Databases; Diet; Diet Records; Dietary Assessment; Dietary Fats; Dietary intake; Disease; Eating; Energy Intake; Energy Metabolism; Evaluation; Fasting; Fatty Acids; Folate; Food; Frequencies; Funding; Future; Gender; Height; Hour; Incidence; Intake; Investigation; Label; Lipids; Literature; Malignant Neoplasms; Measurement; Measures; Methods; Monitor; Morphologic artifacts; Motion; Nitrogen; Nurses' Health Study; Nutrient; Online Systems; Paper; Participant; Patient Self-Report; Physical activity; Plasma; Potassium; Potential Energy; Prospective Studies; Proteins; Public Health; Publishing; Questionnaires; Records; Relative (related person); Relative Risks; Request for Proposals; Research Design; Research Infrastructure; Research Personnel; Self-Administered; Series; Sodium; Stimulus; Structure; System; Time; Training; Validation; Variant; Water; Weight; Woman; Work; base; cohort; design; diet and cancer; disorder risk; instrument; malignant breast neoplasm; men; parent grant; public health relevance; response; time interval; urinary; validation studies

DESCRIPTION (provided by applicant): Large prospective studies of diet and cancer have often not supported hypotheses that were based on animal and ecological findings; one possible explanation could be large measurement errors in the assessment of diet. Thus, NCI has requested proposals for a series collaborative validation/calibration studies imbedded in existing cohorts using a common design with multiple self-reported and biomarker measures of diet and physical activity including doubly labeled water (DLW), urinary nitrogen (UN) and motion monitors. Thus, we propose to conduct such a study among 750 women in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSN), which will be of particular value because these cohorts have provided much of the data that have not supported several prominent hypotheses. Also, in these studies we have already collected extensive dietary data using multiple measures of intake and plasma biomarkers of diet; this will allow the evaluation of the validity of dietary assessment methods over a 20-year period. The proposed study design will consist of two FFQ's administered one year apart; in the year between these measures we will collect four 24-hour recalls using the new NCI automated self-administered 24-hour recall (ASA24), two 7-day dietary records, and biomarkers of diet including one assessment of energy expenditure using doubly-labeled water (DLW, with a replication in 100 women), four 24-hour urinary measures of nitrogen (a measure of protein intake), sodium and potassium, and two fasting blood samples for plasma levels of specific fatty acids, standard lipids, carotenoids, and folate. Physical activity will be assessed twice (together with the FFQ's) by the modified Paffenbarger physical activity questionnaire used in our studies, four 24-hour recalls using an automated system developed by the NCI, twice by an objective physical activity monitor, and by DLW (subtracting resting metabolic rate). These multiple measurements will allow an evaluation of the error structure associated with dietary and physical activity assessment methods, in particular the influences of variation over time for each method and correlated errors between methods. This will provide information of the relative and absolute validity of the different measures, and inform the interpretation of the published literature on diet and cancer (allowing the correction of observed relative risks and confidence intervals for measurement error) and the design of future validation/calibration studies. Additional analyses will indicate the optimal approaches to adjust nutrient intakes for total energy intake, which is critical for the interpretation of epidemiologic findings. PUBLIC HEALTH RELEVANCE: The proposed validation/calibration study will provide quantitative data on the validity of the methods that have been used in cohort studies to measure diet and physical activity. This information would greatly enhance the value of the data that have been collected and would also provide invaluable guidance for the design and collection of future data on diet and physical activity and cancer by other investigators, resulting in great benefit to public health.

描述（由申请人提供）：对饮食和癌症的大量前瞻性研究通常不支持基于动物和生态发现的假设；一种可能的解释可能是评估饮食时的测量错误。因此，NCI已要求提出提案，以使用与多种自我报告和生物标志物的饮食和体育锻炼测量的共同设计嵌入在现有人群中的系列协作验证/校准研究，包括双重标记的水（DLW），尿液氮气（UN）和运动生产者。因此，我们建议对护士健康研究（NHS）和护士健康研究II（NHSN）的750名妇女进行此类研究，这将是特别有价值的，因为这些同类人群提供了许多不支持几个重要假设的数据。同样，在这些研究中，我们已经使用了多种摄入量和血浆生物标志物的饮食数据来收集大量饮食数据。这将允许评估20年内饮食评估方法的有效性。拟议的研究设计将包括两个FFQ相隔一年的管理。在这些措施之间的一年中，我们将使用新的NCI自动化自动化的24小时召回（ASA24），两次7天饮食记录以及饮食的生物标志物，包括一种使用双重标记的水（DLW）（100名妇女重复），四个小时URINARE INTRRINALE（NITRINALE INTRRINAL）（NITROGEN），是NITRRINAL INTRONGEN（NITRINAR），该公司是NITRRINAR INTRONGEN，钾和两个禁食血样，用于特定脂肪酸，标准脂质，类胡萝卜素和叶酸的血浆水平。在我们的研究中使用的修改后的Paffenbarger体育活动问卷调查，将对体育锻炼进行两次（以及FFQ）评估，使用NCI开发的自动化系统，两次通过客观的体育活动监视器和DLW进行了两次24小时召回，并通过DLW（减去静息代谢率）。这些多次测量将允许评估与饮食和体育活动评估方法相关的误差结构，尤其是每种方法随时间变化的影响以及方法之间的误差。这将提供不同度量的相对有效性和绝对有效性的信息，并为发表的有关饮食和癌症的文献解释（允许纠正观察到的相对风险和测量误差的置信区间）以及未来验证/校准研究的设计。其他分析将表明调整营养摄入量以进行总能量摄入的最佳方法，这对于解释流行病学发现至关重要。公共卫生相关性：拟议的验证/校准研究将提供有关在队列研究中用于测量饮食和体育锻炼的方法的有效性的定量数据。这些信息将大大提高收集到的数据的价值，还将为其他研究人员的饮食，体育锻炼和癌症的未来数据和收集提供宝贵的指导，从而对公共卫生带来巨大的好处。