Fetal Programming and Environmental Exposures: Implications for Prenatal Care and

胎儿编程和环境暴露：对产前护理和治疗的影响

• 批准号: 8319101
• 负责人: Sudhansu K Dey
• 金额: $ 1.4万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-07 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319101
• 关键词: Academia; Academy; Address; Adult; Adverse effects; Advocate; Affect; Award; Basic Science; Behavior; Blindness; Cardiovascular Diseases; Cerebrum; Child; Childhood; Chronic; Clinical; Collaborations; Communities; Complex; Congresses; Decidual Cell Reactions; Development; Diabetes Mellitus; Discipline; Disease; Embryo; Endocrine Disruptors; Endocrinologist; Environment; Environmental Exposure; Epidemiologist; Epigenetic Process; Event; Faculty; Family; Fees; Fellowship; Fostering; Future; General Population; Genes; Genetic; Goals; Government; Guidelines; Health; Hormones; Human; Hypertension; Individual; Industry; Infant; International; Intervention; Kidney; Knowledge; Lead; Learning; Learning Disabilities; Link; Lung; Marketing; Medical; Medical center; Minority; Mission; Multimedia; National Institute of Environmental Health Sciences; Neonatal; New York; New York City; Nurses; Online Systems; Oral; Organogenesis; Outcome; Patients; Pediatric Hospitals; Pharmacologic Substance; Physicians; Placentation; Play; Policies; Postdoctoral Fellow; Predisposing Factor; Premature Birth; Prenatal care; Prevention; Prevention strategy; Preventive; Price; Public Health; Publications; Qualifying; Reporting; Reproductive Biology; Reproductive Medicine; Research; Research Personnel; Resolution; Risk; Role; Safety; Science; Scientific Advances and Accomplishments; Scientist; Societies; Solutions; Specialist; Term Birth; Therapeutic; Training; Translational Research; Travel; Woman; Work; abstracting; base; combat; design; disability; discount; economic cost; environmental chemical; environmental toxicology; evidence base; fetal; fetal programming; gene environment interaction; graduate student; hearing impairment; human disease; implantation; improved; in utero; lectures; literacy; member; multidisciplinary; pediatrician; posters; pregnancy disorder; preimplantation; premature; prenatal; prenatal influence; prevent; programs; psychologic; repository; symposium

DESCRIPTION (provided by applic) Over the past two decades, it has been increasingly recognized that the risk of adult health disorders can be markedly influenced by prenatal and infant environmental and pharmaceutical exposures. The New York Academy of Sciences (NYAS) and Cincinnati Children's Hospital Medical Center are jointly presenting a 1.5- day scientific symposium to explore recent discoveries, challenges, and future research directions that further our understanding of the complex environmental and genetic factors, and gene-gene and gene- environment interactions responsible for fetal programming in utero and pre-term birth. Organized by Drs. Sudhansu K. Dey, Jeffrey A. Whitsett, and Susan J. Fisher (investigators), this event will take place at the New York Academy of Sciences conference center in New York City on June 7-8, 2012. The goals of the symposium are to: (i) discuss genetic and epigenetic factors, in addition to environmental exposures in the intrauterine environment that have a profound effect on the trajectory of prenatal development and pre-term birth, including the effects on: implantation; placentation; organogenesis; and neonatal health, and how to combat these effects; (ii) foster and highlight the research contributions of young and minority investigators working in this field; and (iii) develop high-quality, open-access, web-based enduring materials, to disseminate the latest scientific findings from this fast-moving field to the global community. The conference agenda features a Keynote Address, plenary lectures with audience questions and discussion, breakout roundtable discussions, a panel discussion, and networking activities. We anticipate wide participation (200 attendees) by toxicologists, obstetricians, neonatologists, pediatricians, nurse specialists, endocrinologists, epidemiologists, public health and regulatory experts from basic research to clinical settings, including experts in embryonic, fetal, and childhood development, reproductive medicine and biology, and environmental toxicology. The incorporation of poster and short oral presentations by junior investigators selected from submitted abstracts, and the availability of discounted registration prices and travel fellowships will encourage participation of qualified junior investigators, fellos, physicians-in- training, graduate students, and post-docs to attend the conference. We will use targeted marketing to encourage women and minority scientists to apply for these fellowships and to participate in the conference. The discussions originating from this forum and their dissemination will foster cross-disciplinary dialogue and collaborations among complementary research and clinical groups and lead to enhanced translation of research discoveries into: (i) improved understanding of the factors involved in fetal programming in utero and pre-term birth; (ii) the identification of ways in which to predict, assess, and lower the risk of and/or prevent environmental and genetic factors that predispose to adverse fetal outcomes and pre-term birth; and (iii) related, new health and safety guidelines, and public health programs for families and children. 1 PUBLIC HEALTH RELEVANCE: Prenatal and infant environmental and pharmaceutical exposures can adversely influence fetal programming, which plays a role in pre-term birth and lasting adverse effects on pulmonary, renal, and cerebral function, behavior and learning disabilities, and vision and hearing loss and is linked to chronic adult conditions such as diabetes, high blood pressure, and cardiovascular disease. The 1.5-day scientific symposium presented by the New York Academy of Sciences and Cincinnati Children's Hospital Medical Center will provide a neutral forum for toxicologists, obstetricians, neonatologists, pediatricians nurse specialists, endocrinologists, epidemiologists, and public health and regulatory experts from basic research to clinical settings to explore recent discoveries regarding the complex array of environmental (chemical, pharmaceutical or environmental) and genetic factors responsible for fetal programming in utero and pre-term birth. This forum will generate enduring, open-access, online publications to highlight the effects of environmental exposures on embryonic, fetal, and childhood development and reproductive medicine and biology, and will be available to the global scientific community in perpetuity. Thus, this activity will foster cross-disciplinary dialogue and collaboration and promote the development of effective clinical interventions and guidelines, preventive strategies, and new policies to lower the risk of and/or prevent environmental and genetic interactions that predispose to adverse fetal outcomes and pre-term birth.

描述（由申请提供） 在过去的二十年中，人们越来越认识到成人健康疾病的风险可能受到产前和婴儿环境和药物暴露的显着影响。纽约科学院 (NYAS) 和辛辛那提儿童医院医疗中心联合举办为期 1.5 天的科学研讨会，探讨最新发现、挑战和未来研究方向，进一步加深我们对复杂环境和遗传因素以及基因的理解。基因和基因-环境相互作用负责胎儿在子宫内的编程和早产。由博士组织。 Sudhansu K. Dey、Jeffrey A. Whitsett 和 Susan J. Fisher（研究员），该活动将于 2012 年 6 月 7-8 日在纽约市的纽约科学院会议中心举行。 研讨会的目标目的是： (i) 讨论遗传和表观遗传因素，以及对产前发育和早产轨迹有深远影响的宫内环境暴露，包括对以下方面的影响：植入；胎盘植入；器官发生；和新生儿健康，以及如何应对这些影响； (ii) 培养和强调在这一领域工作的年轻和少数族裔研究人员的研究贡献； (iii) 开发高质量、开放获取、基于网络的持久材料，以传播这个快速发展领域的最新科学发现 向全球社会。会议议程包括主题演讲、包含观众提问和讨论的全体演讲、分组圆桌讨论、小组讨论和社交活动。我们预计毒理学家、产科医生、新生儿科医生、儿科医生、护士专家、内分泌学家、流行病学家、 从基础研究到临床环境的公共卫生和监管专家，包括以下领域的专家 胚胎、胎儿和儿童发育、生殖医学和生物学以及环境毒理学。从提交的摘要中选出的初级研究人员将海报和简短的口头报告结合起来，并提供折扣注册价格和旅行奖学金，将鼓励合格的初级研究人员、研究员、实习医生、研究生和博士后参与参加会议。我们将利用有针对性的营销来鼓励女性和少数族裔科学家申请这些奖学金并参加会议。本次论坛的讨论及其传播将促进互补研究和临床小组之间的跨学科对话和合作，并促进研究发现转化为：(i) 增进对子宫内和产前胎儿编程所涉及因素的理解。足月出生； (ii) 确定预测、评估和降低风险和/或预防易导致不良胎儿结局和早产的环境和遗传因素的方法； (iii) 相关的、新的健康和安全指南以及针对家庭和儿童的公共卫生计划。 1 公众健康相关性：产前和婴儿的环境和药物暴露会对胎儿的编程产生不利影响，这会导致早产，并对肺、肾和脑功能、行为和学习障碍、视力和听力损失以及视力和听力损失产生持久的不利影响。与糖尿病、高血压和心血管疾病等慢性成人疾病有关。由纽约科学院和辛辛那提儿童医院医疗中心主办的为期 1.5 天的科学研讨会将为毒理学家、产科医生、新生儿科医生、儿科医生、护士专家、内分泌学家、流行病学家以及从基础研究到公共卫生和监管专家提供一个中立的论坛。临床环境，探索有关导致子宫内胎儿编程和早产的复杂环境（化学、药物或环境）和遗传因素的最新发现。该论坛将产生持久的、开放获取的在线出版物，以强调环境暴露对胚胎、胎儿和儿童发育以及生殖医学和生物学的影响，并将永久提供给全球科学界。因此，这项活动将促进跨学科对话与合作，并促进有效临床干预措施和指南、预防策略和新政策的制定，以降低和/或防止环境和遗传相互作用的风险和/或防止环境和遗传相互作用，这些相互作用容易导致不良胎儿结局和预产期。 -足月出生。

项目成果

Fetal programming and environmental exposures: implications for prenatal care and preterm birth.

胎儿编程和环境暴露：对产前护理和早产的影响。

• 发表时间: 2012-12
• 影响因子: 5.2
• 作者: Schug, Thaddeus T;Erlebacher, Adrian;Leibowitz, Sarah;Ma, Liang;Muglia, Louis J;Rando, Oliver J;Rogers, John M;Romero, Roberto;vom Saal, Frederick S;Wise, David L
• 通讯作者: Wise, David L