Cincinnati Center for Excellence in Molecular Hematology

辛辛那提分子血液学卓越中心

基本信息

批准号：
8509681
负责人：
YI ZHENG
金额：
$ 68.35万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-30 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8509681
关键词：
Academic Medical Centers Affect Area Basic Science Biological Process Bone Marrow Diseases Bone Marrow Transplantation Cancer Center Support Grant Caring Cell Adhesion Molecules Cell Therapy Cell Volumes Cells Cellular biology Child Clinical Clinical Immunology Clinical Management Clinical Research Clinical Trials Code Collection Complement Complex Comprehensive Health Care Development Disease Doctor of Philosophy Environment Erythrocytes Erythropoiesis Experimental Hematology FDA approved Faculty Fanconi&apos s Anemia Flow Cytometry Foundations Functional disorder Funding Future Genes Genetic Genomics Goals Grant Growth Growth Factor Hematological Disease Hematology Hematopoiesis Hematopoietic Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hemoglobinopathies Home environment Human Hypersensitivity Immune Immune system Immunity Immunobiology Immunologic Deficiency Syndromes Immunologics Immunology In Vitro Individual Inherited Innovative Therapy Investments Lentivirus Vector Leukocytes Life Link Medical center Medicine Methods Molecular Molecular Biology Mouse Strains Mus Myelogenous Myeloid Cells National Heart, Lung, and Blood Institute Natural Immunity North America Pancytopenia Participant Pathogenesis Pathway interactions Patients Pediatric Hospitals Peer Review Phase Physicians Physiological Pilot Projects Pneumonia Process Production Publications Rare Diseases Regulation Research Research Infrastructure Research Personnel Research Support Retroviridae Scientist Services Sickle Cell Sickle Cell Anemia Side Signal Pathway Signal Transduction Societies Sorting - Cell Movement Stem cells Structure Subfamily lentivirinae Syndrome Technology Therapeutic Transfusion Transgenic Organisms Translating Translational Research Transplantation United States United States National Institutes of Health Universities Viral Vector Virus Wiskott-Aldrich Syndrome assay development base cell behavior cellular transduction chemokine clinical care college cytokine design gene therapy genetic manipulation immunohematology in vivo inhibitor/antagonist innovation member mouse model oncology patient population pre-clinical pre-clinical research preclinical study programs rho GTP-Binding Proteins small molecule stem stem cell biology trait translational study vector

Academic Medical Centers Affect Area Basic Science Biological Process Bone Marrow Diseases Bone Marrow Transplantation Cancer Center Support Grant Caring Cell Adhesion Molecules Cell Therapy Cell Volumes Cells Cellular biology Child Clinical Clinical Immunology Clinical Management Clinical Research Clinical Trials Code Collection Complement Complex Comprehensive Health Care Development Disease Doctor of Philosophy Environment Erythrocytes Erythropoiesis Experimental Hematology FDA approved Faculty Fanconi&apos s Anemia Flow Cytometry Foundations Functional disorder Funding Future Genes Genetic Genomics Goals Grant Growth Growth Factor Hematological Disease Hematology Hematopoiesis Hematopoietic Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hemoglobinopathies Home environment Human Hypersensitivity Immune Immune system Immunity Immunobiology Immunologic Deficiency Syndromes Immunologics Immunology In Vitro Individual Inherited Innovative Therapy Investments Lentivirus Vector Leukocytes Life Link Medical center Medicine Methods Molecular Molecular Biology Mouse Strains Mus Myelogenous Myeloid Cells National Heart, Lung, and Blood Institute Natural Immunity North America Pancytopenia Participant Pathogenesis Pathway interactions Patients Pediatric Hospitals Peer Review Phase Physicians Physiological Pilot Projects Pneumonia Process Production Publications Rare Diseases Regulation Research Research Infrastructure Research Personnel Research Support Retroviridae Scientist Services Sickle Cell Sickle Cell Anemia Side Signal Pathway Signal Transduction Societies Sorting - Cell Movement Stem cells Structure Subfamily lentivirinae Syndrome Technology Therapeutic Transfusion Transgenic Organisms Translating Translational Research Transplantation United States United States National Institutes of Health Universities Viral Vector Virus Wiskott-Aldrich Syndrome assay development base cell behavior cellular transduction chemokine clinical care college cytokine design gene therapy genetic manipulation immunohematology in vivo inhibitor/antagonist innovation member mouse model oncology patient population pre-clinical pre-clinical research preclinical study programs rho GTP-Binding Proteins small molecule stem stem cell biology trait translational study vector

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项目摘要

The successful application of molecular and cell therapeutics to transplantable hematopoietic cells, including hematopoietic stem cells, holds the promise of life-long cures for inherited diseases of bone marrow-derived cells. The long term goal of the Cincinnati Center of Excellence in Molecular Hematology (CCEMH) is to understand and correct at the molecular level diseases with gene/environmental interactions affecting cells derived from hematopoietic stem cells. We believe that to attain this goal, we must understand basic biological processes that affect lympho-hematopoietic stem cell behavior in vitro and in vivo. We envision this long term goal will be accomplished by inter-disciplinary approaches using state-of-the-art molecular and cell biology methods along with timely and rational use of translational studies in the preclinical and clinical settings. Cincinnati Children's Hospital Medical Center (CCHMC), University of Cincinnati College of Medicine (UC), has developed an intellectual environment that brings together outstanding expertise in virus vector technology, stem cell biology, immune cell biology, basic research in signaling and clinical care in hematology, allergy/immunology and hematopoietic stem cell transplantation. This focus has been greatly strengthened by recruitment of over 50 faculty in these areas in the last 10 years at CCHMC and UC. The areas of basic research are linked by a newly developed and unique Translational Research Initiative, which has facilitated inter-disciplinary interactions and developed an infrastructure that is supporting state-of-the-art trials in cell and gene therapy. Thus, in this application for a new CEMH, we seek to solidify exciting and dramatic growth of research in hematology and related innate immunity/immunology at CCHMC using the shared services and administrative structure of this center grant mechanism. The CCEMH seeks to support a well developed translational research core which complements an outstanding array of basic science cores at CCHMC. These cores are functioning to support innovative research and clinical trials both locally and, in some cases nationally and internationally, in hematology and related immune-based diseases. The relevant cores include a Mouse Xenotransplant/transgenic Core, which maintains specialized mouse strains and provides mouse transplant and transgenic services, a Flow Cytometry Core that includes state-of-the-art hematology flow analysis and sorting capabilities, a Genomics & Genetics Core that support cutting edge genomic analysis of hematologic diseases and normal genetic traits of stem/progenitor cells, and a Translational Core that covers services such as ex vivo manipulation and collection of human cell products, lenti- and retrovirus production, and sophisticated preclinical assay development. Finally, this core grant seeks support for a Pilot/Feasibility program that focuses a highly successful institutional peer-reviewed pilot project initiative into hematologic and related immunologic research and an enhancement program in hosting seminars and annual retreat of the center.

分子和细胞疗法成功地应用于包括造血干细胞在内的可移植造血细胞，具有终身治愈骨髓衍生细胞遗传性疾病的希望。辛辛那提分子血液学卓越中心（CCEMH）的长期目标是在分子水平疾病上理解和纠正，其基因/环境相互作用会影响造血干细胞的细胞。我们认为，要实现这一目标，我们必须了解影响淋巴 - 毛细血管干细胞行为的基本生物学过程。我们设想，将使用最先进的分子和细胞生物学方法以及在临床前和临床环境中及时且合理地使用翻译研究的跨学科方法来实现这一长期目标。辛辛那提大学医学院（UC）的辛辛那提儿童医院医疗中心（CCHMC）已开发出一种智力环境，汇集了病毒媒介技术，干细胞生物学，免疫细胞生物学，信号和临床护理的血液学，敏锐/免疫学和免疫学和血液学干细胞的临床护理方面的杰出专业知识。在过去的十年中，在CCHMC和UC中，这些地区在这些地区招募了50多名教职员工，从而极大地加强了这种重点。基础研究领域与新开发和独特的转化研究计划有关，该计划促进了跨学科的互动，并开发了一种支持细胞和基因治疗中最新试验的基础设施。因此，在此新CEMH的申请中，我们试图使用该中心赠款机制的共享服务和行政结构来巩固CCHMC血液学和相关先天免疫/免疫学研究的令人兴奋的和戏剧性的增长。 CCEMH试图支持一个发达的转化研究核心，该核心与CCHMC的一系列基础科学核心相互补充。这些核心在本地以及在其他情况下在本地和国际上，在血液学和相关的免疫疾病方面都支持创新研究和临床试验。 The relevant cores include a Mouse Xenotransplant/transgenic Core, which maintains specialized mouse strains and provides mouse transplant and transgenic services, a Flow Cytometry Core that includes state-of-the-art hematology flow analysis and sorting capabilities, a Genomics & Genetics Core that support cutting edge genomic analysis of hematologic diseases and normal genetic traits of stem/progenitor cells, and a Translational Core that covers services such as人体细胞产品，扁豆和逆转录病毒产生以及复杂的临床前测定开发的后体操纵和收集。最后，该核心赠款寻求对试点/可行性计划的支持，该计划将一项非常成功的机构同行评审的试点项目计划集中在血液学和相关的免疫学研究中，以及在举办该中心的研讨会和年度静修方面的增强计划。