Auditory Thalamic Implant

听觉丘脑植入物

基本信息

批准号：
8196777
负责人：
STEVEN WAN CHEUNG
金额：
$ 19.31万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-12-01 至 2013-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8196777
关键词：
Acoustic Nerve Acoustics Address Adopted Adult Adverse effects Animals Auditory Auditory area Brain Brain Stem Clinical Cochlea Cochlear Implants Cochlear nucleus Communication Computer Assisted Coupled Craniotomy Deep Brain Stimulation Development Device or Instrument Development Devices Electric Stimulation Electrodes Engineering Feedback Felis catus Frequencies General Anesthesia Goals Hearing Hearing Aids Hearing Impaired Persons Implant Implantation procedure Individual Inferior Colliculus Knowledge Learning Local anesthesia Measures Medial geniculate body Midbrain structure Movement Disorders Neurofibromatosis 2 Neurons Operative Surgical Procedures Organ Outcome Patients Pattern Perception Performance Positioning Attribute Posterior Fossa Prosthesis Rehabilitation therapy Reporting Research Research Project Grants Risk Safety Signal Transduction Site Speech Structure Supratentorial Synapses Techniques Technology Thalamic structure Therapeutic Translating Trephine hole Underserved Population Visual auditory nuclei awake beneficiary bilateral vestibular Schwannoma deafness design hearing impairment implantation improved innovation meetings neurophysiology public health relevance response sensory prosthesis technological innovation

项目摘要

DESCRIPTION (provided by applicant): Deaf neurofibromatosis type 2 (NF2) patients have limited rehabilitation choices. Extracranial cochlear implants are inappropriate for NF2 patients without intact auditory nerves, a consequence of bilateral vestibular schwannomas. Intracranial cochlear nucleus brainstem and inferior colliculus midbrain implants are two possible treatment options. Those devices provide encouraging but relatively modest benefits compared to cochlear implant hearing outcomes in non-NF2 patients. The current conceptual framework for deafness rehabilitation in NF2 patients is implantation of intracranial devices to auditory structures accessible via infratentorial posterior fossa craniotomy under general anesthesia. Direct visual identification of the target auditory nucleus for implant placement is the dominant surgical technique. However, reliable placement and stable positioning of electrodes have been major challenges. An alternate strategy to possibly improve therapeutic outcomes is device implantation of the ventral medial geniculate body via supratentorial burr hole craniotomy under local anesthesia. Adaptation of established deep brain stimulation and computer assisted surgical navigation technologies to target the auditory thalamus would supplant current surgical practices. This project proposes taking initial step towards the development of a clinically deployable auditory thalamic implant. Animal studies are planned to measure electrically driven ventral medial geniculate body thalamocortical transformations that would serve as design parameters to engineer a suitable brain probe and speech processor. PUBLIC HEALTH RELEVANCE: Deaf patients without intact auditory nerves, such as those afflicted by neurofibromatosis type 2, have very limited rehabilitation options. Research to develop a better hearing device is necessary to meet communication needs of this underserved population. Knowledge derived from this project may also help many other hearing impaired individuals.

描述（由申请人提供）：聋神经纤维瘤病2型（NF2）患者的康复选择有限。颅外人工耳蜗植入物不适合没有完整听觉神经的NF2患者，这是双侧前庭schwannomas的结果。颅内耳蜗脑干和下丘中脑植入物是两个可能的治疗选择。与非NF2患者的人工耳蜗听力结果相比，这些设备提供了令人鼓舞但相对适度的好处。 NF2患者聋哑康复的当前概念框架是将颅内装置植入到可以通过大全麻醉下的腹腔后窝颅骨切开术来访问的听觉结构。直接视觉识别用于植入物的目标听觉核是主要的手术技术。但是，电极的可靠放置和稳定的定位是主要的挑战。可能改善治疗结果的替代策略是通过局部麻醉下腹侧内侧基因体的装置植入腹侧内侧遗传体。适应已建立的深脑刺激和计算机辅助手术导航技术以瞄准听觉丘脑，将取代当前的手术实践。该项目提议朝着开发临床上可部署的听觉丘脑植入物迈出第一步。动物研究计划测量电动腹侧内侧遗传体的丘脑皮质转化，该转化将作为设计参数，以设计合适的脑探测器和语音处理器。公共卫生相关性：没有完整听觉神经的聋哑患者，例如受到神经纤维瘤病2型的聋哑人的康复选择非常有限。为了满足服务不足的人群的沟通需求，需要进行更好的听力设备的研究。从该项目获得的知识也可能帮助许多其他听力障碍的人。