Brain Plasticity and Clinical Consequences of Adult-Onset Asymmetric Hearing Loss

成人发病的不对称听力损失的大脑可塑性和临床后果

• 批准号: 10412442
• 负责人: STEVEN WAN CHEUNG
• 金额: $ 68.52万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412442
• 关键词: Acoustic Neuroma; Address; Adult; Aftercare; Auditory; Binaural; Brain; Brain imaging; Clinical; Clinical assessments; Data; Diagnostic; Diffusion Magnetic Resonance Imaging; Ear; Ear Neoplasms; Environment; Functional Magnetic Resonance Imaging; Goals; Hearing; Hearing problem; Impairment; Knowledge; Location; Loudness; Magnetoencephalography; Neuraxis; Numeric Rating Scale; Observational Study; Occupational Noise; Organizational Change; Otosclerosis; Outcome; Outcome Study; Participant; Patients; Perception; Performance; Peripheral; Prevalence; Psychoacoustics; Research; Research Design; Rest; Risk; Severities; Side; Source; Stapedectomies; Stimulus; Structure; Techniques; Testing; Tinnitus; asymmetric hearing loss; base; cohort; deafness; hearing preservation; improved; indexing; innovation; multimodality; neural correlate; neuroimaging; normal hearing; sound; speech recognition; tool

PROJECT SUMMARY Permanent sensorineural asymmetric hearing loss (AHL) disrupts extraction of interaural information for binaural processing. Using a cutoff of at least 15 dB interaural difference as definition of AHL, prevalence estimates vary widely, from 1% to 50%. Among cohorts with occupational noise exposure, AHL prevalence ranges from 15%- 49%. Critical clinical consequences include difficulty with sound target identification in noisy environments and degradation of spatial hearing. Beyond those impairments, the aidable poorer ear in AHL is at risk for accelerated decline and often burdened by tinnitus. There is a wide gap in our understanding of the relationship between central nervous system changes along the continuum of AHL magnitudes, audiological and psychoacoustical outcomes, and tinnitus perception. Closing this knowledge gap would be the first step to advance diagnostic tools and inspire innovative treatments for AHL. Informed by anchoring neuroimaging and audiological data from normal hearing and single-sided deafness, the most extreme form of AHL, we propose to close this knowledge gap. A comprehensive study on the clinical consequences of AHL should address hearing performance under adverse conditions, spatial hearing, and tinnitus outcomes, and their central neural correlates. We propose a longitudinal within-subject neuroimaging features and clinical assessments study of AHL before and after treatment by amplification. We will use resting-state magnetoencephalographic imaging (RS-MEGI) and functional magnetic resonance imaging (RS-fMRI), task-based MEGI, and diffusion MRI to examine temporal, functional and structural features, and audiological and psychoacoustical tests to evaluate hearing performance and tinnitus outcomes. This observational study will collect data from participants who will be treated by routine amplification with individualized tinnitus sound therapies, as required, for AHL. We will evaluate test-retest reliability of neuroimaging features, and assess neuroimaging features, hearing performance, and tinnitus outcomes at baseline and at months 3, 6 and 12 following treatment. The specific aims of this research are to examine: 1) AHL clinical outcomes, 2) AHL auditory interhemispheric temporal organization using MEGI, and 3) AHL whole brain functional and structural neuroimaging features using resting-state MEGI and fMRI (functional), task-based MEGI (functional), and diffusion MRI (structural).

项目摘要 永久性感官不对称听力损失（AHL）破坏了双耳中的室内信息的提取 加工。使用至少15 dB的临界值作为AHL的定义，患病率估计有所不同 广泛从1％到50％。在与职业噪声暴露的队列中，AHL患病率范围为15％ - 49％。关键的临床后果包括在嘈杂环境中的声音目标识别的难度和 空间听力的退化。除了这些障碍之外，AHL的可有助的较差的耳朵有可能 加速下降，经常受到耳鸣的负担。我们对关系的理解有很大差距 中枢神经系统之间的变化沿AHL幅度，听力学和 心理表现和耳鸣感知。缩小此知识差距将是第一步 提前诊断工具并激发AHL的创新治疗方法。通过锚定神经成像和 来自正常听力和单一耳聋的听力学数据是AHL的最极端形式，我们建议 缩小此知识差距。 关于AHL临床后果的全面研究应解决不利的听力表现 条件，空间听力和耳鸣结局及其中心神经相关。我们提出了一个纵向 受试者内神经影像学特征和AHL的临床评估研究在治疗前后 放大。我们将使用静止状态的磁脑化成像（RS-MEGI）和功能磁 共振成像（RS-FMRI），基于任务的MEGI和扩散MRI，以检查时间，功能和 结构特征以及听力学和心理测验，以评估听力表现和耳鸣 结果。这项观察性研究将从参与者那里收集数据，这些数据将通过常规放大对待 根据需要使用个性化耳鸣声疗法。我们将评估重测的测试可靠性 在 治疗后的基线和第3、6和12个月。这项研究的具体目的是检查：1） AHL临床成果，2）AHL听觉跨膜间临时组织使用MEGI，3）AHL整体 使用静止状态MEGI和fMRI（功能），基于任务的脑功能和结构性神经影像学特征 MEGI（功能）和扩散MRI（结构）。

项目成果

Unification of sparse Bayesian learning algorithms for electromagnetic brain imaging with the majorization minimization framework.

• DOI: 10.1016/j.neuroimage.2021.118309
• 发表时间: 2021-10-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Hashemi A;Cai C;Kutyniok G;Müller KR;Nagarajan SS;Haufe S
• 通讯作者: Haufe S

Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography.

• DOI: 10.1007/s10548-021-00850-4
• 发表时间: 2022-01
• 期刊: Brain topography
• 影响因子: 2.7
• 作者: Bhutada AS;Cai C;Mizuiri D;Findlay A;Chen J;Tay A;Kirsch HE;Nagarajan SS
• 通讯作者: Nagarajan SS

Emergence of canonical functional networks from the structural connectome.

• DOI: 10.1016/j.neuroimage.2021.118190
• 发表时间: 2021-08-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Xie X;Cai C;Damasceno PF;Nagarajan SS;Raj A
• 通讯作者: Raj A

Spectral graph theory of brain oscillations.

脑振荡的谱图理论。

• DOI: 10.1002/hbm.24991
• 发表时间: 2020
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Raj,Ashish;Cai,Chang;Xie,Xihe;Palacios,Eva;Owen,Julia;Mukherjee,Pratik;Nagarajan,Srikantan
• 通讯作者: Nagarajan,Srikantan