Instrumentation for microSPECT and microPET imaging

microSPECT 和 microPET 成像仪器

• 批准号: 8763170
• 负责人: peter L choyke
• 金额: $ 61.46万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8763170
• 关键词: Animals; Area; Basic Science; Charge; Chemicals; Clinical Trials; Code; Computer software; Coupled; Custom; DAQ; Data Analyses; Development; Devices; Diagnostic; Disease; Electronics; Evaluation; Event; Future; Gamma Cameras; Goals; Growth and Development function; Human; Image; Imaging Device; Imaging technology; Label; Laboratory Animals; Light; Magnetic Resonance Imaging; Measurement; Medical; Mind; Mission; Mus; Names; National Cancer Institute; Nuclear; Pathway interactions; Photons; Positioning Attribute; Positron-Emission Tomography; Radioisotopes; Radionuclide Imaging; Research; Research Personnel; Scanning; Scientist; Side; Speed; Structure; Support Groups; System; Systems Development; Technology; Testing; Time; Tube; United States National Institutes of Health; Validation; Work; base; cancer therapy; computerized data processing; cost; design; detector; drug development; flexibility; human subject; improved; instrumentation; magnetic field; molecular imaging; news; novel; optical imaging; photomultiplier; programs; simulation software; single photon emission computed tomography; thallium-doped sodium iodide

In 2008, as a first step towards a novel flat panel microPET device the Nuclear Camera Team produced a new dual flat panel projection imaging device for mouse imaging. It consists of two flat panel detectors side-by-side with the ability to rapidly obtain projection image in mice on a portable device. This system is now operational and plans are being put in place to further develop devices that allow tomorgraphic imaging. In 2010 work began on leveraging the first device, code named MONICA for Mobile Nuclear Imaging Camera into a low cost projection microPET employing two parallel detectors (rather than side by side). The design incorporates coincidence scanning between the two plates but also the capability for depth of interaction (DOI) measurement allowing some tomographic abilities. Also in 2010 work began on adapting this device to a projection microPET MR compatible device. Testing is ongoing to determine the ability of new crystals to withstand the effects of a strong magnetic field. Development work carried out by the nucelar camera group and its (essential) collaborators is based on the notion of directed exploration where technological opportunities are examined at the research level but with a particular systems level goal in mind (A): Research areas in imaging system development: (B): current focused systems level development project: dual gamma camera planar projection imaging system for single photon, high-speed dynamic whole body bio-distribution studies in mice. To illustrate this parallelism, work is now underway in each of the areas shown in LaBr3 slab and NaI(Tl) pixelated detector modules and support electronics development (CIT-NIH/RIG); evaluation of a new, modular DAQ system (Thomas Jefferson National Accelerator Facility (JLAB), Newport News, VA/RIG); creation of a high speed data processing interface using both centroid event positioning and advanced Maximum Likelihood (ML) positioning (RIG/CIT); and evaluation of a commercial system (Nuclear Mac) for image display and analysis (RIG/CIT). Each of these sub-system projects are evaluated in light of the current systems level goal of creating a dual planar gamma camera device for imaging mice while at the same time providing information in each technical area for potential use in our next systems level development project. For example, one of the detector modules will be comprised of a rectangular pixelated NaI(Tl) array coupled to two side-by-side Hamamatsu H8500 position-sensitive photomultiplier tubes Initial imaging results obtained with this combination required full use of the JLAB DAQ, CIT developed electronics and RIG-developed data processing software for acquisition and analysis of these data. Thus, considerable progress is being made in the development of novel microSPECT and microPET cameras that could result in much less costly imaging cameras in the future. Moreover, because of their larger coverage, the sensitivity for such devices might be considerably higher leading to the possibility of detecting disease with ever greater sensitivity. Clearly improved camera design could have a significant impact on molecular imaging research in the future. We plan to continue this exploratory work with the goal of turning over the completed dual gamma camera system to MIP scientists , followed by a review of accrued technical findings and designation of the next systems level project.

在2008年，作为迈向新型平板微型设备的第一步，核摄像头团队生产了一种新的双平板投影设备，用于鼠标成像。它由两个平面检测器并排组成，能够在便携式设备上快速获得小鼠投影图像的能力。现在，该系统正在运行，并且正在制定计划，以进一步开发允许横向图像成像的设备。在2010年开始利用第一个设备的工作开始，代码将Monica命名为移动核成像摄像机，使用两个并行探测器（而不是并排）。该设计结合了两个板之间的巧合扫描，但还结合了相互作用深度（DOI）测量的能力，允许某些层压能力。同样在2010年，将该设备改编为投影MicroPET MR兼容设备的工作也开始了。正在进行测试以确定新晶体承受强磁场的影响的能力。 Development work carried out by the nucelar camera group and its (essential) collaborators is based on the notion of directed exploration where technological opportunities are examined at the research level but with a particular systems level goal in mind (A): Research areas in imaging system development: (B): current focused systems level development project: dual gamma camera planar projection imaging system for single photon, high-speed dynamic whole body bio-distribution studies in mice.为了说明这一并行性，现在在LABR3平板和NAI（TL）像素化检测器模块中所示的每个领域正在进行工作，并支持电子开发（CIT-NIH/RIG）；评估新的模块化DAQ系统（Thomas Jefferson National Accelerator设施（JLAB），Newport News，VA/RIG）；使用Centroid事件定位和高级最大似然（ML）定位（RIG/CIT）创建高速数据处理界面；以及用于图像显示和分析的商业系统（核MAC）的评估（RIG/CIT）。根据当前的系统级别的目标，可以评估这些子系统项目中的每一个，即创建双平面伽马摄像头设备以对小鼠进行成像，同时在每个技术领域提供信息，以在我们的下一个系统级别开发项目中潜在使用。例如，其中一个检测器模块将包括一个矩形像素化的NAI（TL）阵列，该阵列与两个并排的Hamamatsu H8500位置敏感的位置敏感的光电型光层层管构成初始成像结果，从而通过此组合完全使用了JLAB DAQ，需要充分利用JLAB DAQ，CIT开发的电子设备和分析的数据处理，并进行了分析数据处理，该数据处理已开发了这些数据。因此，在新型的微观和微型摄像机的开发中正在取得很大的进步，这可能会导致成本较小的成像摄像机。此外，由于它们的覆盖范围较大，对此类设备的敏感性可能更高，从而导致可能以更高的敏感性检测疾病。显然改进的相机设计可能会对未来的分子成像研究产生重大影响。我们计划继续这项探索性工作，目的是将完成的双伽马相机系统移交给MIP科学家，然后对下一个系统级项目的应计技术发现和指定进行审查。