Assessment Of Ras And Renovascular Hypertension By Contr

通过对照评估 Ras 和肾血管性高血压

• 批准号: 6831371
• 负责人: peter L choyke
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6831371
• 关键词: angiography; artery stenosis; bioimaging /biomedical imaging; captopril; clinical trial phase I; diagnosis design /evaluation; diagnosis quality /standard; human subject; inhalation drug administration; kidney disorder diagnosis; kidney imaging /visualization; magnetic resonance imaging; nuclear medicine; oxygen compounds; patient oriented research; radiography; renal hypertension; renal ischemia /hypoxia

The purpose of this protocol is to determine whether magnetic resonance angiography (MRA) and captopril magnetic resonance renography (MRI) can provide comprehensive evaluation of patients at risk for renovascular hypertension. Although renovascular hypertension (renal artery stenosis causing high blood pressure) is unusual, it nonetheless represents a correctable form of hypertension. The current methods of evaluating patients for renovascular hypertension are cumbersome and include Doppler sonography, captopril renography, MRA and angiography. The purpose of this protocol is to test the current gold standards, captopril renography and angiography against a combination of MRA and captopril MR renography. For this study, the at-risk patient undergoes a conventional captopril nuclear medicine renogram followed by an MR renogram and MRA. The patient also breathes an oxygen-rich-gas known as carbogen which is used to test for renal ischemia. To date, we have accrued 6 volunteers and 16 patients to this protocol. We anticipate continued patient accrual to this protocol over the coming year.

该方案的目的是确定磁共振血管造影（MRA）和卡托普利磁共振肾脏术（MRI）是否可以对有肾血管高血压风险的患者进行全面评估。尽管肾血管高血压（引起高血压的肾动脉狭窄）是不寻常的，但它仍然代表了一种可正确的高血压形式。当前评估肾血管高血压患者的方法很麻烦，包括多普勒超声检查，卡托普利肾脏术，MRA和血管造影。该方案的目的是测试当前的金标准，卡托普利肾脏摄影和血管造影，以结合MRA和Captopril MR肾脏摄影。在这项研究中，处于危险的患者经历了常规的卡托普利核医学肾脏图，然后是MR肾脏图和MRA。该患者还呼吸一种富含氧气的气体，称为碳原质，用于测试肾脏缺血。迄今为止，我们已获得6名志愿者和16名患者来制定该方案。我们预计在来年将继续对该方案进行持续应计。