SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALING

南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和应激信号传导中的作用

• 批准号: 8323219
• 负责人: Kenneth D. Tew
• 金额: $ 218.17万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8323219
• 关键词: Aging; Area; Award; Biological; Biomedical Research; Businesses; Calpain; Cardiovascular Diseases; Cell Death; Cells; Centers of Research Excellence; Collaborations; Cytoprotection; Development; Diabetes Mellitus; Discipline; Disease; Environment; Equilibrium; Etiology; Faculty; Fellowship; Fostering; Funding; Future; Goals; Grant; Growth and Development function; Human Pathology; Individual; Inflammation; Injury; Ischemia; Joints; Journals; Laboratories; Laboratory Research; Link; Malignant Neoplasms; Medical; Mentors; Mentorship; Mitochondria; Molecular; Motivation; Nerve Degeneration; Neurodegenerative Disorders; Neurosciences; Nitrogen; Outcome; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen; Participant; Pathology; Pathway interactions; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Pharmacy facility; Positioning Attribute; Post-Translational Protein Processing; Postdoctoral Fellow; Program Development; Proteins; Proteomics; Radiation; Recording of previous events; Recruitment Activity; Reperfusion Therapy; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Research Support; Research Technics; Resources; Science; Scientist; Signal Pathway; Signal Transduction; Source; South Carolina; Stress; Therapeutic; Training; United States National Institutes of Health; Universities; Xenobiotics; cancer initiation; carcinogenesis; career; career development; cellular imaging; college; doctoral student; drug development; drug discovery; experience; gene therapy; graduate student; interest; member; metabolomics; molecular imaging; neuron loss; novel therapeutics; pre-doctoral; programs; research and development; response; small molecule; success; toxicant

This COBRE program seeks to bring together individuals with existing expertise in oxidants, redox balance and stress signaling at the Medical University of South Carolina. Our long-term plan is to develop in South Carolina a Center of Excellence in this scientific discipline or with this scientific focus. To this end we have constructed an infrastructure that will provide a mentoring environment for five target faculty members with research interests in calpains and diabetes signaling pathways, oxidative pathways in mitochondria, reactive oxygen (ROS) and nitrogen (RNS) species and peroxiredoxins in cancer initiation, ROS/RNS and the unfolded protein response and oxidative pathways of neuronal cell death. Their projects provide interdisciplinary opportunities and are supported by three scientific cores in Proteomics, Metabolomics and Cell and Molecular Imaging. The central hypothesis is that redox regulated pathways impact significantly on the pathobiology of diseases such as cancer, aging, diabetes, inflammation and neurodegeneration. The administrative core will facilitate a plethora of functions including, business management, faculty development, mentoring and program planning and sustainability. We have appointed oversight committees to include Steering, Internal Advisors and External Advisors. The latter two groups contain individuals who have broad scientific expertise in the chosen discipline and also extensive mentoring experience. Future development of the program is also served by MUSC fiscal support and the creation of new and renovated space that will permit additional faculty recruitments with complementary expertise

该 COBRE 项目旨在将南卡罗来纳医科大学在氧化剂、氧化还原平衡和压力信号传导方面现有专业知识的个人聚集在一起。我们的长期计划是在南卡罗来纳州建立一个该科学学科或该科学重点的卓越中心。为此，我们构建了一个基础设施，为五名目标教员提供指导环境，他们的研究兴趣包括钙蛋白酶和糖尿病信号通路、线粒体氧化通路、活性氧（ROS）和氮（RNS）物种以及癌症引发中的过氧化还原蛋白、ROS/RNS 以及未折叠的蛋白质反应和神经元细胞死亡的氧化途径。他们的项目提供跨学科机会，并得到蛋白质组学、代谢组学以及细胞和分子成像三个科学核心的支持。核心假设是氧化还原调节途径对癌症、衰老、糖尿病、炎症和神经退行性疾病等疾病的病理生物学有显着影响。行政核心将促进多种职能，包括业务管理、教师发展、指导和项目规划以及可持续性。我们任命了监督委员会，其中包括指导委员会、内部顾问和外部顾问。后两组成员在所选学科中拥有广泛的科学专业知识以及丰富的指导经验。该项目的未来发展还得到了 MUSC 的财政支持以及新建和翻新空间的创建，这将允许招聘更多具有互补专业知识的教师