South Carolina COBRE in Oxidants, Redox Balance and Stress Signaling

南卡罗来纳州 COBRE 在氧化剂、氧化还原平衡和压力信号方面的作用

• 批准号: 10460360
• 负责人: Kenneth D. Tew
• 金额: $ 113.25万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10460360
• 关键词: Accountability; Achievement; Advisory Committees; Analytical Biochemistry; Area; Automobile Driving; Award; Bioenergetics; Biology; Biomedical Research; Biotechnology; Cancer Center; Cardiovascular Diseases; Cells; Centers of Research Excellence; Collaborations; Complement; Core Facility; Diabetes Mellitus; Discipline; Disease; Disease Pathway; Drug Addiction; Economics; Engineering; Equilibrium; Equipment; Extramural Activities; Faculty; Financial Support; Fostering; Funding; Gastrointestinal Agents; Gastrointestinal Diseases; Goals; Grant; Growth; Health; Homeostasis; Human; Human Pathology; Image; Individual; Infrastructure; Institution; Interdisciplinary Study; Malignant Neoplasms; Mass Spectrum Analysis; Medical; Medicine; Mentors; Metabolic dysfunction; Mission; Modeling; Molecular; Musculoskeletal; National Institute of General Medical Sciences; Neurodegenerative Disorders; Organism; Oxidants; Oxidation-Reduction; Oxidative Phosphorylation; Oxidative Stress; Oxygen; Paper; Pathologic; Pathway interactions; Peer Review; Phase; Pilot Projects; Positioning Attribute; Proteomics; Published Comment; Publishing; Recovery; Research; Research Infrastructure; Research Personnel; Research Training; Resolution; Resource Sharing; Resources; Role; Scientific Advances and Accomplishments; Secure; Services; Signal Transduction; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Source; South Carolina; Stress; Talents; Teacher Professional Development; Therapeutic Intervention; Tissues; Toxic effect; Translational Research; United States National Institutes of Health; Universities; Workforce Development; base; career; collaborative environment; college; commercial application; cost; design; experience; faculty support; human disease; imaging capabilities; improved; infrastructure development; mass spectrometric imaging; member; microscopic imaging; multidisciplinary; new technology; novel; outreach; programs; recruit; success; targeted treatment; translational goal

Overall – Abstract With Phase III COBRE support, the South Carolina Center in Oxidants, Redox Balance, and Stress Signaling (Redox COBRE) at the Medical University of South Carolina (MUSC) will complete its transition to long-term sustainability as a nationally competitive multidisciplinary research program in redox pathobiology. During Phases I and II, our Redox COBRE was successful in its efforts to (i) expand the critical mass of funded investigators at MUSC studying the causal role of redox pathways and metabolic dysfunction in a wide range of human pathologies (cancer, cardiovascular and neurodegenerative diseases, diabetes, gastrointestinal disorders and drug addiction) and (ii) develop advanced scientific core resources offering a broad range of capabilities for investigating the biologically significant effects of oxidative stress. Our current core membership comprises 44 senior and junior faculty members that have received more than $51 million in awards since the program’s inception. To date, the Redox COBRE has mentored a total of 20 target faculty (junior investigators + pilot project-supported PIs). Of these individuals, 10 have been promoted and 16 have been retained at our institution. As a group, these faculty members have published more than 250 peer-reviewed papers and secured 56 extramural grant awards (including 31 NIH grants (PI role) of which 16 are R01 awards and 8 are SBIR/STTR- supported start-ups). The major components of this Phase III proposal are: (1) an Administrative Core providing organizational, coordinating, fiscal and accountability functions; (2) an Analytical Redox Core delivering analytical biochemistry services for quantification of redox-sensitive molecule abundance and redox-based changes in cellular homeostasis; (3) a Proteomics Core that offers state-of-the-art mass spectrometry (MS) and MS-imaging capabilities; (4) a Cell & Molecular Redox Imaging Core that provides cell and tissue-based confocal, multiphoton and super-resolution microscopic imaging; and (5) a Pilot Projects Program (PPP) that fosters research endeavors utilizing Center resources and facilitates collaborations with Redox COBRE members. Towards our objective of becoming a stand-alone Center of Redox Biology and Signaling (abbreviated to “Redox Center”), we will build upon our substantial scientific and institutional achievements, to: (Aim 1) enhance the function and efficiencies of our scientific cores, achieving optimal positioning to serve Center thematic and translational goals and achieve/ maintain sustainability; (Aim 2) leverage the PPP to grow center membership and promote the importance of translational redox signaling research in the context of human disease; (Aim 3) develop the research portfolio and connections between the Redox COBRE and other IDeA programs to establish ourselves as a national presence coalescing various disciplines and areas of expertise. Thus, we are seeking to establish a strategic position for long-term success as an emergent, University- designated Redox Center that will be one of few national resources for investigators to utilize or develop new technologies, therapeutics and interventions targeting pathological redox pathways.

总体 – 摘要 在第三阶段 COBRE 的支持下，南卡罗来纳州氧化剂、氧化还原平衡和压力信号中心 南卡罗来纳医科大学 (MUSC) 的 Redox COBRE（氧化还原 COBRE）将完成向长期的过渡 作为氧化还原病理学领域具有全国竞争力的多学科研究项目的可持续性。 在第一阶段和第二阶段，我们的氧化还原 COBRE 成功地努力 (i) 扩大了资助的临界质量 MUSC 的研究人员正在研究氧化还原途径和代谢功能障碍在多种疾病中的因果作用 人类病理学（癌症、心血管和神经退行性疾病、糖尿病、胃肠道疾病） (ii) 开发先进的科学核心资源，提供广泛的 我们目前的核心成员具有研究氧化应激的生物学显着影响的能力。 由 44 名高级和初级教员组成，自成立以来，他们已获得超过 5100 万美元的奖项 迄今为止，Redox COBRE 已指导了总共 20 名目标教师（初级研究员 + 试点项目支持的 PI 中，10 人已晋升，16 人留任。 作为一个整体，这些教员发表了 250 多篇经过同行评审的论文并获得了认可。 56 项校外资助（包括 31 项 NIH 资助（PI 角色），其中 16 项为 R01 奖，8 项为 SBIR/STTR- 第三阶段提案的主要组成部分是：(1) 一个行政核心，提供 (2) 分析氧化还原核心提供 用于氧化还原敏感分子丰度和基于氧化还原的定量分析生物化学服务 细胞稳态的变化；(3) 蛋白质组学核心，提供最先进的质谱 (MS) 和 MS 成像功能；(4) 细胞和分子氧化还原成像核心，提供基于细胞和组织的成像 共焦、多光子和超分辨率显微成像；以及 (5) 试点项目计划 (PPP) 利用中心资源促进研究工作并促进与 Redox COBRE 的合作 实现我们成为独立的氧化还原生物学和信号传导中心（缩写）的目标。 “氧化还原中心”），我们将在我们实质性的科学和机构成就的基础上，实现：（目标 1） 增强我们科学核心的功能和效率，实现服务中心的最佳定位 主题和转化目标并实现/维持可持续性；（目标 2）利用 PPP 来发展中心； 成员资格并促进人类背景下转化氧化还原信号研究的重要性 疾病；（目标 3）开发 Redox COBRE 和其他 IDeA 之间的研究组合和联系 旨在将我们自身打造为融合不同学科和专业领域的全国性影响力的计划。 因此，我们正在寻求作为一所新兴的大学建立长期成功的战略地位。 指定的氧化还原中心将成为研究人员利用或开发新材料的少数国家资源之一 针对病理氧化还原途径的技术、治疗方法和干预措施。