Bioinformatics and Biostatistics

生物信息学和生物统计学

• 批准号: 8376412
• 负责人: Shannon K. McWeeney
• 金额: $ 42.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8376412
• 关键词: Address; Algorithms; Animal Model; Behavior; Bioinformatics; Biological; Biometry; Biostatistics Core; Communities; Computational Biology; Computer Simulation; Consultations; Data; Data Analyses; Development; Emerging Technologies; Ensure; Experimental Designs; Immunology; Joints; Knowledge; Leadership; Life Cycle Stages; Manuscripts; Methodology; Methods; Pacific Northwest; Pilot Projects; Preparation; Public Health; Recording of previous events; Research Design; Research Personnel; Research Project Grants; Resources; Sample Size; System; Systems Biology; Technical Expertise; Technology; Training; Training Programs; Training and Education; Virulence; Work; career development; comparative; cost effective; data integration; design; functional genomics; mathematical model; network models; reconstruction; research study; therapeutic target; tool

The Bioinformatics & Biostatistics Core (BBC) will provide biostatistics and bioinformatics support to the entire PNWRCE. The Core will work closely with the PNWRCE investigators to assist with study design and analysis throughout the "experimental life cycle". Biostatistical support includes power and sample size calculations, statistical analysis, as well as assistance with data interpretation and manuscript preparation. Bioinformatics support includes functional genomic data analysis and integration, network reconstruction and predictions, as well as mathematical modeling and simulation. The Core has joint leadership from OHSU and PNNL providing inter-disciplinary and inter-institutional expertise. In addition, the BBC will provide education and training, as well as consultations for career development and pilot projects. Finally, in order to stay responsive and dynamic to changes in technology, the BBC will provide cutting-edge methodological and algorithm development. As there is no existing core or resource which has the unique combination of technical expertise, domain knowledge and collaborative history with the PNWRCE investigators, the creation of the BBC is well justified and will allow cost-effective and efficient support for the RCE.

生物信息学和生物统计学核心（BBC）将为生物统计学和生物信息学支持 整个 PNWRCE。核心将与 PNWRCE 研究人员密切合作，协助研究设计和 整个“实验生命周期”的分析。生物统计支持包括功效和样本量 计算、统计分析以及数据解释和手稿准备方面的协助。 生物信息学支持包括功能基因组数据分析和整合、网络重建和 预测以及数学建模和模拟。该核心由 OHSU 和 PNNL 提供跨学科和跨机构的专业知识。此外，BBC还将提供教育 培训以及职业发展和试点项目咨询。最后，为了留下来 BBC 将提供前沿的方法论和技术，以响应并动态地响应技术的变化。 算法开发。由于不存在具有独特组合的现有核心或资源 技术专长、领域知识以及与 PNWRCE 研究人员的合作历史、 BBC 的创建是充分合理的，并将为 RCE 提供具有成本效益和高效的支持。