FaceBase Management and Coordination Hub

FaceBase 管理和协调中心

基本信息

批准号：
8833430
负责人：
JEFFREY C MURRAY
金额：
$ 22.08万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-21 至 2016-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Advances in imaging, genome technology, subclinical phenotyping, embryology and other investigative disciplines have provided unique opportunities for developing a better understanding of mid-face development. Clefts that involve the mid-face, in particular those of the lip and the palate are among the most common birth defects and create life-long challenges for affected individuals. These concerns include repeated surgeries, as well as speech, behavior, dental and long-term health issues such as increased risks for cancer and delayed cognitive development. We have assembled a team of committed and experienced craniofacial researchers, plus experts in bioinformatics and computer science, to develop a Face Base Hub that will facilitate research, clinical, and educational activities related to facial development. Our Face Base team consists of collaborators who have worked well together for many years and who bring far-reaching and complementary expertise to the Hub. Our Hub will provide a Face Base web portal, access to extensive databases of both human and animal model data (such as genotypes, sequence data, expression data, facial images and other phenotypes) and a comprehensive set of web-based tools to enhance research opportunities. It will focus on integrating data from diverse sources and models, and to foster translational research in cleft lip and palate. The Hub will provide a forum for connecting investigators, and opportunities to maintain updated information in real-time on research and clinical aspects of cleft lip and palate. It will include educational and biorepository activities that will enhance clinical and public understanding of, and involvement in, facial research. We will build on existing bioinformatic infrastructures that can be adopted for Face Base, utilizing partnerships with such programs as CaBIG, the UCSC genome-browser, and Wikipedia. The outcome will be a significant increase in the ability to rapidly advance craniofacial research, new educational and outreach activities to enhance public and professional awareness of mid-face defects and a future model for broadening these activities across other dental and craniofacial disorders.

描述（由申请人提供）：成像，基因组技术，亚临床表型，胚胎学和其他调查学科的进展为更好地理解中面的发展提供了独特的机会。涉及中脸的裂口，尤其是嘴唇和口感的裂口是最常见的先天缺陷之一，并为受影响的个体带来了终身挑战。这些担忧包括反复的手术以及言语，行为，牙科和长期健康问题，例如增加癌症风险和延迟认知发展的风险。我们组建了一个由忠诚和经验丰富的颅面研究人员以及生物信息学和计算机科学专家组成的团队，以开发一个面部基础枢纽，以促进与面部发展有关的研究，临床和教育活动。我们的脸部基础团队由合作者组成，他们共同努力了很多年，并为枢纽带来了深远和互补的专业知识。我们的枢纽将提供一个面部基础网络门户网站，访问人与动物模型数据的广泛数据库（例如基因型，序列数据，表达数据，面部图像和其他表型）以及一组基于Web的工具，以增强研究机会。它将专注于整合来自不同来源和模型的数据，并在唇cle裂和口感中培养翻译研究。该枢纽将提供一个与调查人员联系的论坛，以及实时维护最新信息的机会，以了解有关唇裂和口感的研究和临床方面。它将包括教育和生物座席活动，这些活动将增强对面部研究的临床和公众了解和参与。我们将建立在现有的生物信息学基础架构的基础上，这些基础架构可以用于面部基础，并利用与Cabig，UCSC Genome-Browser和Wikipedia等计划的合作伙伴关系。结果将大大提高迅速发展颅面研究的能力，新的教育和外展活动，以增强公众对中间缺陷的认识以及未来的模型，以扩大其他牙科和颅面疾病的这些活动。