Biostatistics and Bioinformatics Core

生物统计学和生物信息学核心

• 批准号: 10327947
• 负责人: Shannon K. McWeeney
• 金额: $ 15.39万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10327947
• 关键词: Back; Bioinformatics; Biological; Biology; Biometry; Collaborations; Complex; Computing Methodologies; Cytomegalovirus; Data; Development; Ensure; Event; FAIR principles; Generations; Genomics; Goals; Hematopoietic stem cells; Human; Infrastructure; Intervention; Knowledge Extraction; Life Cycle Stages; Methodology; Methods; MicroRNAs; Modeling; Molecular; Molecular Profiling; Pathology; Pathway interactions; Phase; Play; Protocols documentation; Regulation; Reproducibility; Research Design; Research Project Grants; Role; Secure; Security; Signal Pathway; Signal Transduction; Standardization; System; Technology; Time; Viral; Virus; Visualization; Visualization software; Work; candidate validation; catalyst; cost effective; data management; data standards; experimental study; insight; mathematical model; method development; multiple omics; novel; outreach; phenotypic data; predictive modeling; programs; virus virus interaction

SUMMARY - BIOSTATISTICS AND BIOINFORMATICS CORE (CORE B) The Biostatistics and Bioinformatics Core (Core B) serves as the translational catalyst for the PPG by integrating the diverse ‘omics’ data readouts to develop systems-level mathematical models to help advance the molecular understanding of HCMV latency and reactivation. Core B works in close collaboration with the PPG research projects and the other cores to provide pre-processing, analysis, modeling and computational support as well as development of timely new methods through cutting-edge computational methods development; outreach support; and assistance with dissemination. To achieve the full potential of the PPG center, it is essential that data be accessible—in terms of both security (i.e., having secure, ready access) and interpretability (i.e., is high quality, contextual and information rich). Core B serves as the data steward for the PPG. The goal of Core B is to support all aspects of the data life cycle starting at data generation. The Core B team will build upon its extensive data management, data standardization, biostatistical, multi-omics, and bioinformatics expertise to ensure reproducible, transparent workflows and protocols that maximize knowledge extraction.

摘要 - 生物统计学和生物信息学核心（核心 B） 生物统计学和生物信息学核心（核心 B）通过整合作为 PPG 的转化催化剂 不同的“组学”数据读数可开发系统级数学模型，帮助推进分子生物学 对 HCMV 潜伏期和重新激活的了解 Core B 与 PPG 研究密切合作。 项目和其他核心提供预处理、分析、建模和计算支持 通过尖端计算方法的开发及时开发新方法； 为了充分发挥 PPG 中心的潜力，以下几点至关重要： 数据可访问——在安全性（即具有安全、易于访问）和可解释性（即高 质量、上下文和信息丰富） 核心 B 充当 PPG 的数据管理员 核心 B 的目标是。 从数据生成开始，支持数据生命周期的各个方面。 广泛的数据管理、数据标准化、生物统计、多组学和生物信息学专业知识 确保可重复、透明的工作流程和协议，最大限度地提取知识。