2012 International LAM Research Conference

2012年国际LAM研究会议

• 批准号: 8318344
• 负责人: Francis Xavier McCormack
• 金额: $ 1.9万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-04 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8318344
• 关键词: Address; Air; Award; Basic Science; Biology; Cells; Clinical; Clinical Management; Clinical Sciences; Clinical Trials Design; Complement; Connective Tissue; Conscious; Consensus; Discipline; Estrogens; Family; Family member; Foundations; Funding; Future; Gender; Gene Mutation; Genetic; Goals; Gonadal Steroid Hormones; Grant; Growth Factor; Image; Infiltration; International; Interstitial Lung Diseases; Link; Lung; Lung Transplantation; Lung diseases; Lymphangiogenesis; Lymphangioleiomyomatosis; Metalloproteases; Mind; Molecular; Nationalities; Outcome; Participant; Pathogenesis; Pathology; Patient Participation; Patients; Pleural; Pregnancy; Race; Radiology Specialty; Recording of previous events; Recruitment Activity; Research; Research Personnel; Role; Running; Signal Transduction; Smooth Muscle; Transcriptional Regulation; Travel; Tuberous Sclerosis; United States National Institutes of Health; Woman; abstracting; base; hormone therapy; human FRAP1 protein; innovation; meetings; multidisciplinary; patient oriented; posters; research and development; symposium; teacher; trafficking

DESCRIPTION (provided by applicant): The LAM Foundation 2012 Lymphangioleiomyomatosis International Research Conference will focus on the molecular mechanisms of smooth muscle proliferation and cystic lung destruction that occur in the fatal lung disease of women, Lymphangioleiomyomatosis (LAM). This is the thirteenth annual Cincinnati LAM conference, which has evolved from a dedicated family/patient conference to a state of the art scientific meeting for LAM and tuberous sclerosis. The basic science sessions will highlight research on the cellular and genetic basis of smooth muscle proliferation in LAM, and will focus on the role of exogenous growth factors, sex hormones, genetic mutations, lymphangiogenesis, intracellular signaling mechanisms and changes in transcriptional regulation. Additional sessions will explore the link between smooth muscle infiltration of the lungs and the cystic remodeling of pulmonary parenchyma, including the elaboration of metalloproteinases and connective tissue matrix by LAM cells. Concurrent clinical sessions will address difficult management issues in LAM, including hormonal therapy, air travel, pregnancy, lung transplantation and pleural complications. The Basic and Clinical Science tracks have been coordinated to allow all participants to attend keynote sessions and to traffic freely between sessions. A patient-oriented seminar will address key clinical issues for 175 LAM patients and LAM family members who are expected to attend, and will culminate in a summary of scientific sessions by the Basic and Clinical Track Chairs. A scientific roundtable discussion is held on the last day of the conference to review the key outcomes of the conference and to plan future conferences. Each session will be chaired by an expert in the field and will have invited speakers as well as speakers chosen from the pool of submitted abstracts. There has been a conscious effort to attract established investigators from related disciplines who can complement the expertise of the current pool of LAM investigators. Discussion facilitated by a discussion leader will be an important component of all sessions. Outstanding junior investigators will be awarded travel grants and will be given the opportunity to present their research in platform and poster formats. The goal of this conference is to provide a forum for leading experts to discuss the molecular and cellular basis of LAM, review the clinical management of LAM, to present cutting edge research, to integrate concepts and to identify creative and innovative research directions.

描述（由申请人提供）：LAM 基金会 2012 年淋巴管平滑肌瘤病国际研究会议将重点关注女性致命肺部疾病淋巴管平滑肌瘤病 (LAM) 中发生的平滑肌增殖和囊性肺破坏的分子机制。这是第十三届辛辛那提 LAM 年度会议，该会议已从专门的家庭/患者会议发展成为 LAM 和结节性硬化症最先进的科学会议。基础科学会议将重点研究 LAM 平滑肌增殖的细胞和遗传基础，并将重点关注外源生长因子、性激素、基因突变、淋巴管生成、细胞内信号传导机制和转录调控变化的作用。其他会议将探讨肺部平滑肌浸润与肺实质囊性重塑之间的联系，包括 LAM 细胞对金属蛋白酶和结缔组织基质的加工。同期临床会议将解决 LAM 的棘手管理问题，包括激素治疗、航空旅行、怀孕、肺移植和胸膜并发症。基础科学和临床科学轨道经过协调，允许所有参与者参加主题演讲会议并在会议之间自由交流。一场以患者为导向的研讨会将为预计参加的 175 名 LAM 患者和 LAM 家庭成员解决关键的临床问题，并将由基础和临床分会主席对科学会议进行总结。会议最后一天举行科学圆桌讨论，回顾会议主要成果并规划未来会议。每场会议将由该领域的专家主持，并邀请演讲者以及从提交的摘要中选出的演讲者。我们有意识地努力吸引来自相关学科的成熟研究人员，他们可以补充现有 LAM 研究人员的专业知识。由讨论主持人主持的讨论将是所有会议的重要组成部分。杰出的初级研究员将获得旅费补助，并将有机会以平台和海报的形式展示他们的研究成果。本次会议的目标是为顶尖专家提供一个论坛，讨论 LAM 的分子和细胞基础，回顾 LAM 的临床管理，展示前沿研究，整合概念并确定创造性和创新性的研究方向。