The Acute Alcohol-Suicide Attempt Relation as a Function of Alcohol Use Disorders

急性酒精与自杀企图的关系与酒精使用障碍的关系

基本信息

批准号：
8515737
负责人：
COURTNEY L BAGGE
金额：
$ 16.51万
依托单位：
UNIVERSITY OF MISSISSIPPI MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8515737
关键词：
Acute Aggressive behavior Alcohol consumption Alcohol or Other Drugs use Alcohols Bipolar Disorder Characteristics Chronic Clinical Complex Consumption Cross-Over Studies Crossover Design Data Development Diagnosis Diagnostic Distal Drug usage Evaluation Event Exercise Exploratory/Developmental Grant Feeling suicidal Frequencies Future Gender Hour Identification (Psychology)Impulsivity Individual Injury Interview Life Major Depressive Disorder Measures Medical Methods Modification Mood Disorders Myocardial Infarction Participant Patient Self-Report Pattern Physiological Prevalence Prevention Public Health Quality of life Questionnaires Recording of previous events Recruitment Activity Recurrence Reporting Research Risk Risk Factors Role Severities Subgroup Suicide Suicide attempt Theoretical model Time Typology United States accomplished suicide alcohol abuse therapy alcohol effect alcohol risk alcohol use disorder base chronic alcohol ingestion clinically relevant demographics depressive symptoms design drinking experience interest male meetings psychologic suicidal suicidal behavior suicidal morbidity suicide attempter trait trend

项目摘要

DESCRIPTION (provided by applicant): In the United States alone, more than 32,000 people commit suicide each year and it is estimated that for every death by suicide there are 8-25 nonfatal suicide attempts. Given the clinical and public health significance of suicide, there is considerable interest in identifying proximal factors that increase the risk for suicide attempts and that determine the timing of suicide attempts among individuals who often report persistent suicidal ideation. Despite consistent findings of an elevated prevalence of alcohol use surrounding suicide attempts, little is known about whether acute alcohol use serves as a trigger to suicide attempts, or whether the effect of acute alcohol use on suicide attempt differs as a function of chronic alcohol use. Disentangling the effects of acute alcohol use and risk of injury according to an individual's usual consumption pattern is a matter of great public health interest, and there are known differences in psychological characteristics (e.g., mood disorders, previous treatment history) between those who attempt suicide with and without alcohol use disorders (AUD), as well as between individuals who drink alcohol (A+) and who do not drink alcohol (A-) prior to their attempt. However, little is known about differences on such factors between suicide attempters with AUD+ (who do or do not use alcohol immediately prior to their attempt), AUD- individuals who use alcohol before their attempt, and AUD- individuals who do not consume alcohol prior to their attempt. In the proposed exploratory/ developmental study (R21), we will examine the unique triggering role of acute alcohol use on suicide attempts as a function of an individual's baseline AUD status, and will also examine distal psychological characteristics of distinct groups of attempters characterized by acute and chronic alcohol use. To this end, we will employ a case-crossover design with a between-subject comparison, recruiting 150 individuals presenting for medical evaluation after a suicide attempt. The one-session assessment will comprise a diagnostic measure of AUD, a battery of questionnaires assessing psychological characteristics, and a standard interview assessing substance use and other time-varying proximal risk factors during the six hours prior to the suicide attempt, as well as during two matched controls periods. This exploratory/developmental study will provide preliminary data on the magnitude of the unique within-subject relation between acute alcohol use and attempt among individuals with and without AUD, and will aid in identifying distinguishing characteristics of groups of attempters characterized by different patterns of acute and chronic alcohol use. These preliminary data and effect sizes will be used to inform the development of a larger study. Gaining a better understanding of the triggering effects of acute alcohol use on suicide attempts among those with and without AUD, and identifying psychological characteristics of individuals with different acute and chronic alcohol use patterns will facilitate future identification and treatment of alcohol-related suicide attempts.

描述（由申请人提供）：仅在美国，每年有32,000多人自杀，据估计，每次自杀死亡都有8-25次非致命自杀企图。鉴于自杀的临床和公共卫生意义，人们对确定近端因素有很大的兴趣，这些因素会增加自杀企图的风险，并确定经常报告持续性自杀意念的个体中自杀企图的时机。尽管对自杀未遂的饮酒患病率升高，但对急性饮酒是否作为自杀企图的触发因素，还是急性酒精使用对自杀企图的影响尚不了解。根据个人的常规消费方式删除急性饮酒和受伤的风险是极大的公共卫生利益的问题，并且在尝试使用或没有酒精饮酒障碍的人（AUD）以及在尝试之前不喝酒（A+）的人之间，在心理特征（例如情绪障碍，以前的治疗史）上存在已知差异（例如情绪障碍，以前的治疗史）。但是，关于AUD+的自杀式示威者（在尝试之前或不使用酒精的人），在尝试之前使用酒精的人以及在尝试之前不食用酒精的AUD的人之间的自杀案件之间的差异知之甚少。在拟议的探索/发展研究（R21）中，我们将研究急性酒精使用在自杀尝试中的独特触发作用，这是个人基线AUD状态的函数，还将研究以急性和慢性酒精使用为特征的不同型望远镜的远端心理特征。为此，我们将采用案例交叉设计和主体间比较，招募了150名自杀企图后进行医学评估的人。一项课程评估将包括一项诊断量的AUD衡量标准，一系列评估心理特征的问卷以及在自杀企图前六个小时以及在两个匹配的控件期间的六个小时内评估药物使用和其他较及时的近端风险因素的标准访谈。这项探索性/发展研究将提供有关急性酒精使用与具有AUD和没有AUD的个体之间独特内部关系的大小的初步数据，并有助于确定以不同急性模式为特征的Attempters的区别特征和慢性酒精使用。这些初步的数据和效果大小将用于告知一项更大的研究的发展。更好地了解急性饮酒对患有和没有AUD的人的自杀尝试的触发作用，并确定具有不同急性和慢性酒精使用模式的个体的心理特征，将有助于对与酒精相关的自杀尝试的未来识别和治疗。