SMALL GRANT 4: SEROTONIN, IMPULSIVITY AND SUICIDE ATTEMPTS

小额资助 4：血清素、冲动和自杀企图

• 批准号: 8360512
• 负责人: COURTNEY L BAGGE
• 金额: $ 3.83万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360512
• 关键词: Biological; Cereals; Characteristics; Clinical; Data; Development; Diagnosis; Disease susceptibility; Funding; Genes; Genetic Polymorphism; Goals; Grant; Healthcare Systems; Impulsive Behavior; Impulsivity; Individual; Inpatients; Laboratories; Link; Measures; National Center for Research Resources; Nature; Neurosciences; Participant; Patient Self-Report; Principal Investigator; Process; Public Health; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Resources; Saliva; Sampling; Serotonin; Signal Transduction; Source; Suicide; Suicide attempt; TDO2 gene; Theoretical model; Tryptophan 5-monooxygenase; United States National Institutes of Health; Violence; base; behavior measurement; case control; cost; design; genetic association; improved; interest; suicidal behavior; suicide attempter; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Given the clinical and public health significance of suicide, there is considerable interest in identifying factors that are associated with the diathesis for suicide attempts. There are well-established links between impulsivity and suicide attempts, but the nature of these associations remain unclear. One reason for this may be due to the heterogeneous nature of the construct of impulsivity, and it is largely unknown which specific facets of impulsivity relate to suicide attempts. The propensity for impulsive behavior has also been consistently linked to biological mechanisms implicated in suicidal behavior. Examining genetic associations with facets of impulsivity may provide a clearer signal in the search for serotonergic genes associated with suicide attempts. The present proposal seeks to examine the inter-relations among serotonergic genes, facets of impulsivity, and suicide attempts. To achieve this research goal, we will employ a case-control design, recruiting 200 psychiatric inpatients (100 suicide attempters and 100 non-suicidal controls). The two-session assessment will comprise 1) a comprehensive assessment (Axis I and II diagnoses, history of suicide attempt and characteristics of attempt, and facets of impulsivity), and 2) a laboratory session where participants will complete five behavioral measures of impulsivity. At the end of the comprehensive assessment, a saliva sample will be collected in order to examine polymorphisms in serotonergic genes (Tryptophan Hydroxylase [TPH2], and 5HTT). This study will provide preliminary data on the magnitude of the relation between polymorphisms of serotonergic genes and facets of impulsivity on suicide attempt, as well as the effect of polymorphisms of serotonergic genes on facets of impulsivity. These preliminary data and effect sizes will be used to inform the development of a larger study. Of note, an important aspect of this research is that it will establish biological, self-reported, and laboratory-based measures of distinct impulsivity processes relating to suicide attempts, as well as a suicide attempt characteristics (violent attempts). Given the high cost of suicidality to individuals and to the health care system, gaining a fine-grained understanding of impulsivity-suicide attempt associations is a critical step in allowing us to refine our theoretical models, improve our assessment tools, and suggest better treatments for suicide attempts.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 鉴于自杀的临床和公共卫生意义，人们对确定与自杀企图素质相关的因素非常感兴趣。冲动和自杀企图之间存在明确的联系，但这些联系的性质仍不清楚。造成这种情况的原因之一可能是由于冲动构造的异质性，并且很大程度上不知道冲动的哪些具体方面与自杀企图有关。冲动行为的倾向也一直与自杀行为的生物机制有关。检查与冲动方面的遗传关联可能会在寻找与自杀企图相关的血清素基因时提供更清晰的信号。本提案旨在研究血清素能基因、冲动的各个方面和自杀企图之间的相互关系。 为了实现这一研究目标，我们将采用病例对照设计，招募 200 名精神病住院患者（100 名自杀企图者和 100 名非自杀对照）。两次评估将包括 1) 综合评估（轴 I 和 II 诊断、自杀企图历史和企图特征以及冲动的各个方面），以及 2) 实验室会议，参与者将完成五项冲动行为测量。综合评估结束后，将收集唾液样本，以检查血清素能基因（色氨酸羟化酶[TPH2]和5HTT）的多态性。 这项研究将提供关于血清素能基因多态性与自杀企图冲动方面之间关系的程度以及血清素能基因多态性对冲动方面影响的初步数据。这些初步数据和效应大小将用于为更大规模研究的开展提供信息。值得注意的是，这项研究的一个重要方面是，它将建立与自杀企图相关的不同冲动过程的生物学、自我报告和基于实验室的测量方法，以及自杀企图特征（暴力企图）。鉴于自杀对个人和医疗保健系统造成的高昂成本，对冲动与自杀企图关联的深入了解是关键的一步，使我们能够完善我们的理论模型，改进我们的评估工具，并提出更好的治疗方法。自杀企图。