Animal Core

动物核心

• 批准号: 8381036
• 负责人: TOSHIHIKO KAWAMORI
• 金额: $ 7.91万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8381036
• 关键词: Animal Cancer Model; Animal Experimentation; Animal Model; Animals; Area; Autopsy; Breast; Cancer Biology; Cancer Model; Colon; Complex; Data Analyses; Databases; Engineering; Ensure; Equipment; Evaluation; Genetically Engineered Mouse; Head and neck structure; Health; Individual; Inflammation; Investigation; Malignant Neoplasms; Modeling; Mus; Pathogenesis; Pathology; Program Research Project Grants; Prostate; Research; Research Infrastructure; Research Project Grants; Resources; Rodent; Sphingolipids; Tongue; Transgenic Organisms; Work; animal breeding; animal resource; base; cancer therapy; carcinogenesis; chemical carcinogen; cost; lung carcinogenesis; mouse model; programs; success

The overall objective of the Animal Core is to provide the Project Leaders with the ability to utilize animal carcinogenesis models in the execution of their research projects and to maintain genetically engineered animals for the investigation of the mechanisms involved in the pathogenesis of cancer. The Animal Core will serve as a resource for conducting the use of all animal manipulations needed in the program. The Animal Core will minimize the cost of utilizing animal models in the Program research projects by consolidating the equipment, expertise, and animal resources. This will ensure an efficient use of animal research at minimal cost and will reduce variables that could compromise data analysis among projects. The overall aims of the proposal are: Specific Aim 1. Ensure the efficient planning, purchase, and utilization of experimental animals, including transgenic and genetically altered mice; maintain stocks of all animals; and breed animals for the individual Projects. We will maintain the animals needed for the Project's research and will work with the Project Leaders to identify and generate animals needed for the proposed studies. Specific Aim 2. Provide the necessary facilities and expertise for carcinogenesis models to support the Research Projects. The Core will provide resources and expertise in animal models of cancer and inflammation. This will include colon, tongue (head & neck), breast, prostate, and lung carcinogenesis models using chemical carcinogens or genetically engineered mouse cancer models as well as inflammation models. Specific Aim 3. Provide expertise in rodent pathology with up-to-date proficiency in cancer pathobiology. The Core director has extensive expertise in the area of pathology to provide the necessary infrastructure. The Core will organize the animal database including animal health and final pathological evaluations at necropsy. This database will be used to input all animal-specific results obtained by the Projects, to allow complex, cross-correlation-based data analysis. These efforts will facilitate the conduct of research in this proposal and will provide the expertise to support the Project Leaders. With the amalgamation of carcinogenesis models and genetically engineered mouse models in sphingolipids, this core is already evolving as a unique and enabling core that is critical for the success of the Program Project.

动物核心的总体目标是为项目负责人提供利用动物的能力 执行其研究项目中的致癌模型并保持基因工程 动物研究癌症发病机理所涉及的机制。动物核心将 作为进行程序中所需的所有动物操作的使用的资源。动物 核心将通过合并计划研究项目中利用动物模型的成本 设备，专业知识和动物资源。这将确保有效利用动物研究的最低用途 成本并将减少可能损害项目数据分析的变量。总体目标 建议是：特定目标1。确保实验的有效计划，购买和利用 动物，包括转基因和遗传改变的小鼠；维持所有动物的库存；和繁殖 单个项目的动物。我们将维护该项目研究所需的动物，并将 与项目负责人合作，识别并产生拟议研究所需的动物。具体的 目标2。为致癌模型提供必要的设施和专业知识，以支持 研究项目。核心将在癌症动物模型和 炎。这将包括结肠，舌头（头颈），乳房，前列腺和肺癌发生模型 使用化学致癌物或基因设计的小鼠癌模型以及炎症模型。 特定目标3。提供啮齿动物病理学的专业知识，具有最新的癌症熟练程度 病理生物学。核心主任在病理领域具有广泛的专业知识，以提供必要的 基础设施。核心将组织动物数据库，包括动物健康和最终病理 尸检的评估。该数据库将用于输入所有动物特异性结果 项目，允许基于复杂的互相关数据分析。这些努力将促进 在此提案中进行研究，并将为支持项目领导者提供专业知识。与合并 在鞘脂中的癌变模型和基因工程的小鼠模型中，该核心已经是 发展为对程序项目成功至关重要的独特而有利的核心。