Core Center Administrative Shell

核心中心管理外壳

• 批准号: 8491769
• 负责人: Robert F. Margolskee
• 金额: $ 5.9万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8491769
• 关键词: Academia; Advisory Committees; American Association for the Advancement of Science; Appointment; Area; Basic Science; Behavior; Behavioral; Beryllium; Biochemistry; Biological; Biophysics; Books; Cations; Cell Culture Techniques; Cells; Chemicals; Clinical Research; Collaborations; Core Facility; DNA; Direct Costs; Disease; Disputes; Educational workshop; Effectiveness; Endocrine; Ensure; Environment; Faculty; Floor; Fostering; Foundations; Funding; G-substrate; GTP-Binding Proteins; Genes; Genetic; Genotype; Goals; Grant; Head; Health; Histology; Hormones; Human Resources; Individual; Industry; Institutes; International; Intestines; Journals; Knockout Mice; Knowledge; Laboratories; Medical; Medical Faculty; Medicine; Messenger RNA; Mission; Molecular; Molecular Biology; Molecular Genetics; Molecular Neurobiology; Monitor; Mus; National Institute on Deafness and Other Communication Disorders; Nature; Nerve; Neurosciences; Operative Surgical Procedures; Oral; Pancreas; Paper; Peer Review; Pennsylvania; Pharmacology; Phenotype; Physiological; Physiology; Postdoctoral Fellow; Procedures; Productivity; Protein Subunits; Proteins; Publications; Publishing; RNA analysis; Receptor Cell; Records; Reproducibility; Research; Research Activity; Research Personnel; Research Project Grants; Resolution; Resource Allocation; Resources; Role; Running; Schedule; Science; Seminal; Services; Signal Transduction; Signaling Molecule; Signaling Protein; Site; Strategic Planning; Sweetening Agents; Taste Perception; Testing; Time; Training; Training Programs; Transducin; Transgenic Mice; Transgenic Model; Travel; Trust; Trustees; United States National Academy of Sciences; United States National Institutes of Health; Universities; Work; base; cost; experience; improved; in vivo; interdisciplinary approach; lectures; medical schools; meetings; member; mouse model; new technology; operation; oral tissue; organizational structure; post-doctoral training; pre-doctoral; preference; programs; ranpirnase; rat Gnat3 protein; receptor; response; skills; sugar; symposium

The Administrative Shell will coordinate and manage all activities of the PSO Core Center for the Chemical Senses. The PI of the Core Center, Dr. Robert Margolskee. and the Administrative Coordinator. Ms. Lee, will coordinate operations of the Core Center through the Administrative Shell. Specific administrative functions of the Shell include coordinating between the Core Center's Research Cores and Research Base and seeing that the Research Cores are fully utilized, that priority is granted to Research Base users, that fair use of Cores is followed, and that the Core's procedures for dispute resolution are followed. Administrative Shell personnel also are responsible for tracking Core Center expenses, monitoring chargeback costs for each Core, booking lectures and training sessions given by the Research Core Directors, scheduling meetings of the Core Center's Internal and External Advisory Boards, and assisting with making travel arrangements for the external advisors. The Monell Chemical Senses Center was founded in 1968 on the premise that basic and clinical research into the health-related impact of the chemical senses would be facilitated by having a center of excellence devoted exclusively to these topics. As a 501(C)(3) organization, Monell is headed by a Board of Directors who are legally and fiscally responsible for its operations. The Board is headed by Dr. Dwight Riskey, former Senior Vice President of PepsiCo. Among its members are two University of Pennsylvania trustees and one senior member of the University of Pennsylvania medical faculty, the President of the Monell Foundation, the CEO of AAAS, a senior executive of the Pew Charitable Trusts, and Dr. Gary Beauchamp. the Director of Monell since 1990. Monell has several advisory groups, the most important of which is the International Advisory Committee made up of distinguished individuals from academia and industry. In addition to overseeing longterm fiscal and research activities at Monell, the Board appoints the Director, who is responsible for day-to-day operations at Monell. The Director is also involved in long-term strategic planning, faculty appointments, and resource allocation. The PSO Core Center for the Chemical Senses is a natural extension of Monell's 42-year mission. The organizational structure of Monell and how the Core Center fits in is shown in Figure 1. The Shell promotes the mission of our Core Center to provide efficient technical services and educate our users in new technologies. For each Research Core, their laboratories and the offices of their Directors are within the same building, often on the same floor, and sometimes in adjacent space. The physical distances between Cores, which are in two adjacent, connected buildings (e.g.. Core 1. Histology in Monell East and Core 2. Genotyping in Monell West), are modest and can be covered in 5 minutes or less. Frequent (daily) conversations occur among all Core Directors. The Administrative Shell's role in the PSO Core Center is key to facilitate these interactions, yet the size and cost of the Administrative Shell are modest, taking up only -6% of the total direct costs of the PSO Core Center. The P30 PI and Core Center Director overseeing the Administrative Shell is Dr. Robert Margolskee. Dr. Margolskee is a world-renowned expert on the molecular mechanisms of taste signaling. His group discovered the first taste transduction protein, gustducin, as well as additional taste signaling proteins: the G-protein subunit Gyl 3, the sweet and umami taste receptor subunit Tl rS, and the Ca2+-activated cation channel TrpmS. His lab was the first to generate and utilize transgenic models in the chemical senses with studies of gustducin-null mice. His group has also generated and characterized knockout mice lacking transducin, TIrS, and Trpm5. His several seminal contributions to the taste field have been published in high-impact journals, including Nature, Science, Nature Genetics, and Proceedings of the National Academy of Sciences of the USA. Having trained in molecular genetics, molecular neurobiology, and medicine, his research program is characterized by an interdisciplinary approach utilizing biochemistry, molecular biology, transgenic mouse models, behavior, and physiology. During the past few years he has extended his studies to investigate the roles of taste-signaling proteins in endocrine responses of extra-oral tissues. His group recently demonstrated that gustducin, TIrS, and other taste elements are expressed in intestinal and pancreatic endocrine cells, where they are involved in detecting sugars and sweeteners and eliciting hormone release. Dr. Margolskee joined Monell in July of 2009 as a Member, Monell Center's highest faculty level. He is also Director of Monell's TS2 Postdoctoral Training Program. For the prior 1S years he was on the faculty of the Mount Sinai School of Medicine in the Departments of Neuroscience, Pharmacology, and Physiology and Biophysics. For eight of those years he was also an Investigator with the Howard Hughes Medical Institute. During his 23 years as a PI, Dr. Margolskee has trained 40 pre- and postdoctoral fellows. Many of his trainees have gone on to establish themselves in academia or industry. Dr. Margolskee currently holds three ROIs, all of which are in the Research Base, and two industry-funded research grants. Dr. Margolskee has significant administrative experience: in addition to Directing Monell's T32 Postdoctoral Training Program, he has served as Co-Director of Mount Sinai's Graduate Training Area in Mechanisms of Disease and Therapy, Founder and Acting President of Linguagen/Redpoint Bio (a biotech company). Program Chair for the Association for Chemoreception Sciences annual meeting, and Co-Chair of the Gordon Conference in the Chemical Senses. Dr. Margolskee will oversee the PSO Core Center and coordinate Core personnel. He is well suited for this role based on his scientific expertise and administrative experience. His research in taste signaling and the roles of taste signaling proteins in extra-oral sites is central to the mission area of NIDCD. Dr. Margolskee has many years of direct experience and has acquired skills and knowledge in each of the technical areas covered by the four Research Cores: Histology, Genotyping, Molecular Biology, and Phenotyping. Specific examples from his work include the creation and characterization of mice null for the taste cell signaling molecules gustducin, transducin, Trpm5, and T1r3. His group has created gene constructs for conventional and conditional null mice, made transgenic mouse models, genotyped mice, localized proteins and mRNAs to subsets of taste receptors cells, done molecular biological analyses of gene products in cell culture and of genes in vivo, and carried out two-bottle preference tests, gustometer tests, gustatory nerve recording, and surgical manipulation of gustatory and gut physiology. Dr. Margolskee and all four core directors (Drs. Huang, Reed, Mosinger, and Bachmanov) talk many times a day concerning scientific and administrative matters. Drs. Huang, Reed, and Bachmanov have adjacent offices. The frequent collaboration common among Dr. Margolskee and the Research Core Directors are exemplified by the multiple co-authored publications; for instance. Dr. Margolskee has co-authored papers with each of the four Core Directors, Drs. Reed and Bachmanov have jointly authored 19 peer-reviewed papers, and Drs. Margolskee and Mosinger have jointly authored 17 papers. Because of the physical proximity and the long-standing collaborations of the Core Directors, questions or problems about Center management generally can be resolved quickly and amicably.

行政外壳将协调和管理PSO核心中心的所有活动。核心中心的PI Robert Margolskee博士。和行政协调员。李女士将通过行政壳来协调核心中心的操作。外壳的具体管理职能包括在核心中心的研究核心和研究基础之间进行协调，并确保研究核心已充分利用，优先级是研究基础用户的优先级，公平利用核心是 随后，遵循核心解决程序的程序。行政外壳人员还负责跟踪核心中心费用，监视每个核心的拒绝费用，预订研究核心主管的讲座和培训会议，安排内部和外部咨询委员会的安排会议，并协助为外部顾问做出旅行安排。 Monell Chemical Senses中心成立于1968年，前提是，基本和临床研究对化学感官的健康相关影响将通过拥有专门用于这些主题的卓越中心来促进化学感官的影响。作为501（c）（3）组织，Monell由合法和财政负责其运营负责的董事会领导。董事会由百事可乐前高级副总裁德怀特·里斯基（Dwight Riskey）博士领导。它的成员包括宾夕法尼亚大学两名受托人，以及宾夕法尼亚大学医学院的一名高级成员，莫内尔基金会主席，首席执行官 Pew Charitable Trusts的高级主管AAAS和Gary Beauchamp博士。自1990年以来，Monell的主任。Monell有几个咨询小组，其中最重要的是国际咨询委员会由杰出的人组成的学术界和工业组成。除了监督Monell的长期财政和研究活动外，董事会还任命了负责在Monell日常运营的董事。董事还参与了长期战略计划，任命和资源分配。 PSO化学感官中心是Monell 42年任务的自然扩展。 Monell的组织结构以及核心中心如何适应图1。壳牌促进了我们核心中心提供有效的技术服务的使命，并向用户提供新技术的教育。对于每个研究核心，他们的实验室和董事办公室都位于同一建筑物内，通常在同一楼层，有时在相邻的空间内。岩心之间的物理距离，它们位于两个相邻的连接建筑物中（例如，核心1。莫内尔东部和核心的组织学2。基因分型 在Monell West），谦虚，可以在5分钟或更短的时间内覆盖。在所有核心主管之间进行频繁的（日常）对话。行政外壳在PSO核心中心的作用是促进这些互动的关键，但是行政外壳的大小和成本却适中，仅占PSO核心中心总直接成本的-6％。 Robert Margolskee博士是PI PI和核心中心负责人。 Margolskee博士是味觉信号传导分子机制的世界知名专家。他的小组发现了第一种味道转导蛋白Gustducin以及其他味道信号蛋白：G蛋白亚基Gyl 3，甜和鲜味的味觉受体亚基TL RS以及Ca2+激活的阳离子阳离子通道TRPM。他的实验室是第一个在化学感官中生成和利用转基因模型的实验室。他的小组还产生并表征了缺乏透明蛋白的淘汰小鼠，Tirs， 和TRPM5。他对口味领域的一些开创性贡献已在高影响力期刊上发表，包括自然，科学，自然遗传学以及美国国家科学院的论文集。在接受分子遗传学，分子神经生物学和医学的培训后，他的研究计划的特征是采用生物化学，分子生物学，转基因小鼠模型，行为和生理学的跨学科方法。在过去的几年中，他扩展了研究，以研究味觉信号蛋白在异内组织内分泌反应中的作用。他的小组最近证明，胃素，TIR和其他味道元素在肠道和胰腺内分泌细胞中表达， 它们参与检测糖和甜味剂以及引起激素释放的地方。 Margolskee博士于2009年7月加入Monell，作为Monell Center最高教职员工的成员。他还是Monell TS2博士后培训计划的主任。在过去的1年中，他在神经科学，药理学，生理学和生物物理学系的西奈山医学院学院任职。在那些年的八年中，他还是霍华德·休斯医学院的调查员。 在担任PI的23年中，Margolskee博士培训了40名前和博士后研究员。他的许多学员已经在学术界或行业中建立了自己的成就。 Margolskee博士目前持有三个ROI，所有这些都在研究基础上，以及两项由行业资助的研究补助金。 Margolskee博士还具有丰富的行政经验：除了指导Monell的T32博士后培训计划外，他还担任西奈山的研究生培训领域的疾病和治疗机制的联合主任，Linguagen/Redpoint Bio（一家生物技术公司）的创始人兼代理总裁。化学科学协会计划年度会议计划主席，以及化学感官戈登会议的联合主席。 Margolskee博士将监督PSO核心中心并协调核心人员。根据他的科学专业知识和行政经验，他非常适合这一职位。他在口味信号传导和口味信号蛋白在外部位的作用是NIDCD任务区域的核心。 Margolskee博士拥有多年的直接经验，并在四个研究核心涵盖的每个技术领域中都获得了技能和知识：组织学，基因分型，分子生物学和表型。他的具体例子 工作包括用于味道细胞信号分子古斯杜蛋白，跨杜以生意，tranducin，trpm5和t1r3的无效小鼠的创建和表征。 His group has created gene constructs for conventional and conditional null mice, made transgenic mouse models, genotyped mice, localized proteins and mRNAs to subsets of taste receptors cells, done molecular biological analyses of gene products in cell culture and of genes in vivo, and carried out two-bottle preference tests, gustometer tests, gustatory nerve recording, and surgical manipulation of gustatory and gut生理学。 Margolskee博士和所有四个核心董事（黄，Reed，Mosinger和Bachmanov博士）每天很多次谈论科学和行政问题。博士。黄，里德和巴赫曼诺夫设有相邻的办公室。玛格尔斯基（Margolskee）博士和研究核心主管的经常合作被多个共同作者的出版物举例说明了。例如。 Margolskee博士与四个核心董事Drs中的每一个合着了论文。里德（Reed）和巴赫曼诺夫（Bachmanov）共同撰写了19份同行评审的论文和博士。 Margolskee和Mosinger共同撰写了17篇论文。由于核心董事的身体接近和长期合作，通常可以快速而友好地解决有关中心管理的问题或问题。