Core Center - NIDCD Research Core Center P30

核心中心 - NIDCD 研究核心中心 P30

• 批准号: 8526210
• 负责人: Edwin W Rubel
• 金额: $ 67.09万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-25 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8526210
• 关键词: 3-Dimensional; Animals; Area; Auditory; Behavioral; Breeding; Center Core Grants; Collaborations; Communication; Communication impairment; Computers; Confocal Microscopy; Contracts; DNA; DNA Sequence Analysis; Direct Costs; Disease; Educational process of instructing; Equilibrium; Equipment; Funding Agency; Genetic; Grant; Group Meetings; Health; Hearing; Hearing problem; Human; Human Resources; Image; Inbreeding; Infant; Investigation; K-Series Research Career Programs; Lead; Maintenance; Microscopic; Mission; Mouse Strains; National Institute on Deafness and Other Communication Disorders; Phenotype; Physiological; Prevention; Process; Recruitment Activity; Reporting; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Schedule; Science; Services; Solutions; System; Time; Universities; Washington; base; body system; digital; efficacy research; equilibration disorder; hearing impairment; human subject; imaging modality; improved; meetings; mouse model; operation; programs; ranpirnase; reconstruction; screening; skills; software development

DESCRIPTION (provided by applicant): The UW P30 Research Core Center Grant from NIDCD provides important infrastructure support for a large research commitment of the University of Washington to the mission areas of NIDCD. The Research Base is composed of 15 grants to 15 investigators with an annual direct cost of over $3 million. In addition, nine grants and one K-award, three R03 grants and one contract are included because they are in the mission area of NIDCD. Four Research Cores provide support for the research programs, and stimulate interactions and collaborations among investigators. Core A, the Human Subjects Recruitment Core, continues the longstanding function of recruiting and scheduling human infant subjects that meet specific criteria for studies on communication sciences and disorders. This Research Core has added services that facilitate recruitment of subjects with specific hearing impairments. Core B, the Computer Resources Core (Computer Core), provides personnel with skills needed for software development for real-time physiological and behavioral investigations of auditory processing in animals and humans. Also, a systems and network manager teaches and advises investigators on optimal computer solutions. Core C, the Imaging Core, provides personnel and equipment maintenance for programs making extensive use of modern digital microscopic imaging methods including confocal microscopy, 3-dimensional reconstructions, and quantitative analyses of cellular attributes. Core D, the Genetics Core, controls breeding and DNA screening for investigators using inbred and genetically manipulated mouse strains. Equipment is provided for rapid analyses of DNA sequences, and for phenotyping hearing and balance disorders to enhance the efficiency of studies using mouse models of communication disorders. The Research Cores are supported by an Administrative Core that oversees the operations of each Research Core, organizes group meetings, provides clerical, fiscal, and personnel support, and prepares reports to the funding agency.

描述（由申请人提供）：NIDCD的UW P30研究核心中心拨款为华盛顿大学对NIDCD的任务领域的大量研究承诺提供了重要的基础设施支持。该研究基础由15名调查人员的15赠与组成，其直接成本超过300万美元。此外，还包括9个赠款和一项K-award，3份R03赠款和一份合同，因为它们在NIDCD的任务领域。四个研究核心为研究计划提供了支持，并刺激了研究人员之间的互动和协作。核心A，人类受试者招募核心，继续招募和安排人类婴儿的长期功能，这些受试者符合有关交流科学和疾病研究的特定标准。该研究核心增加了服务，以促进具有特定听力障碍的受试者的招募。 Core B，计算机资源核心（计算机核心）为人员提供了软件开发所需的技能，以实时对动物和人类听觉处理的实时生理和行为调查。此外，系统和网络经理还向调查人员提供有关最佳计算机解决方案的建议。核心C（成像核心）为程序提供了人员和设备维护，用于广泛使用现代数字显微镜成像方法，包括共焦显微镜，三维重建以及对细胞属性的定量分析。核D（遗传学核心）使用近交和遗传操纵的小鼠菌株来控制研究人员的繁殖和DNA筛查。提供了用于快速分析DNA序列的设备，以及使用小鼠通讯障碍模型来提高研究和平衡疾病的表型。研究核心得到了一个管理核心的支持，该核心负责监督每个研究核心的运作，组织小组会议，提供文书，财政和人员支持，并为资助机构准备报告。