USC-UCLA Drug-Induced Liver Injjry (DILI) Clinical Center

USC-UCLA 药物性肝损伤 (DILI) 临床中心

• 批准号: 8132964
• 负责人: ANDREW Abba STOLZ
• 金额: $ 26.48万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132964
• 关键词: Ancillary Study; Awareness; Clinical; Clinical Data; Collection; Consent Forms; County; Coupled; Enrollment; Future; Goals; Health Personnel; Healthcare Systems; Injury; Institutional Review Boards; Joints; Knowledge; Liver; Los Angeles; Manuals; Medical center; Pharmaceutical Preparations; Pharmacists; Population Heterogeneity; Preparation; Principal Investigator; Process; Protocols documentation; Public Health; Publications; Published Comment; Research Infrastructure; Research Personnel; Resources; Scientific Advances and Accomplishments; Shipping; Ships; Site; Site Visit; Source; Specimen; System; Talents; Testing; United States; base; design; interest; medical schools; meetings; operation; patient population; population based; repository; research clinical testing; response; tool

DESCRIPTION (provided by applicant): The USC-UCLA Drug Induced Liver Injury (DILI) Clinical Center (CC) proposal in response to RFA-DK-07-012 "Continuation and Expansion of the Drug Induced Liver Injury Network (DILIN)" hopes to joint the other established CCs to advance the scientific knowledge and the clinical evaluation of DILI. Our proposal combines the only two medical schools in Los Angeles County allowing us to uniquely capture DILI cases in this large, ethnically diverse population. The 10.3 M residents of Los Angeles County (2007) are an unmatched resource composed of the most ethnically diverse populations in the United States. We have proposed to increase the identification of potential DILI cases within the health care systems of USC, UCLA and the County of Los Angeles Department of Public Health by developing didactic tools targetted to specific groups of health care providers. In addition to our unique patient population, this proposal is built upon the expertise and talents from the USC and UCLA Medical Centers. The Specific Aims of the USC-UCLA DILI CC are to: 1) Review existing DILIN documents in preparation for joining the DILIN 2) Establish the USC-UCLA DILI CC infrastructure at USC and UCLA, 3) Establish the toll-free referral line and distribute IRB-approved documents to networks of potential health care providers and pharmacists who will be a referral sources for potential DILI cases. 4) Develop educational tools to increase DILI awareness and to enhance DILI case referrals from both affiliated and non-affiliated health care providers 5) Screen and enroll eligible subjects into the DILIN for collection of clinical data and specimens 6) Collaborate with other investigators, participate in the organization and operation of the DILIN, and assist with the design of future ancillary studies.

描述（由申请人提供）： USC-UCLA 药物性肝损伤 (DILI) 临床中心 (CC) 的提案响应 RFA-DK-07-012“药物性肝损伤网络 (DILIN) 的延续和扩展”希望联合其他已建立的 CC 来推进 DILI 的科学知识和临床评估。我们的提案结合了洛杉矶县仅有的两所医学院，使我们能够在这个庞大的、种族多元化的人口中独特地捕获 DILI 病例。洛杉矶县的 1030 万居民（2007 年）是由美国最多元化的人口组成的无与伦比的资源。我们建议通过开发针对特定医疗保健提供者群体的教学工具，在南加州大学、加州大学洛杉矶分校和洛杉矶县公共卫生部的医疗保健系统内增加对潜在 DILI 病例的识别。除了我们独特的患者群体之外，该提案还建立在南加州大学和加州大学洛杉矶分校医疗中心的专业知识和人才的基础上。 USC-UCLA DILI CC 的具体目标是： 1) 审查现有的 DILIN 文件，为加入 DILIN 做准备 2) 在 USC 和 UCLA 建立 USC-UCLA DILI CC 基础设施， 3) 建立免费转诊热线和将 IRB 批准的文件分发给潜在的医疗保健提供者和药剂师网络，他们将成为潜在 DILI 病例的转介来源。 4) 开发教育工具，以提高 DILI 意识，并加强附属和非附属医疗保健提供者的 DILI 病例转介 5) 筛选合格受试者并将其纳入 DILIN，以收集临床数据和标本 6) 与其他研究人员合作，参与参与 DILIN 的组织和运作，并协助设计未来的辅助研究。