Error Detection and Error Awareness in Incarcerated Cocaine Dependent Individuals

被监禁的可卡因依赖者的错误检测和错误意识

• 批准号: 8485557
• 负责人: Matthew Shane
• 金额: $ 34.52万
• 依托单位: THE MIND RESEARCH NETWORK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8485557
• 关键词: Abstinence; Adult; Alcohol or Other Drugs use; Anterior; Attention; Awareness; Behavior; Behavioral; Characteristics; Chronic; Clinical Research; Cocaine; Cocaine Abuse; Cognitive; Commit; Comorbidity; Conflict (Psychology); Conscious; Cues; Data; Dependency; Detection; Development; Diagnosis; Disease; Drug usage; Epidemiologic Studies; Equilibrium; Error Sources; Evaluation; Evaluation Indexes; Exertion; Feedback; Female; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Future; General Population; Goals; Gray unit of radiation dose; Human; Image; Impairment; Imprisonment; Individual; Investigation; Laboratories; Lead; Learning; Link; Literature; Magnetic Resonance Imaging; Mental disorders; Methods; Mind-Body Method; Mission; Modeling; Monitor; Nature; Neurocognitive; New Mexico; Nucleus Accumbens; Participant; Pattern; Performance; Personal Satisfaction; Pharmaceutical Preparations; Play; Population; Preparation; Prevalence; Process; Punishment; Regression Analysis; Regulation; Relapse; Reporting; Research; Rewards; Risk; Risk-Taking; Role; Sampling; Signal Transduction; Substance abuse problem; System; Techniques; Testing; Time; Undifferentiated; Use of New Techniques; Work; addiction; adverse outcome; analog; base; control trial; coping; craving; executive function; expectation; experience; follow-up; hemodynamics; indexing; male; meetings; neural circuit; neuroimaging; neuromechanism; non-drug; novel; psychologic; psychopathic personality; public health relevance; relating to nervous system; response; social; substance abuser; tool; treatment program

DESCRIPTION (provided by applicant): Real-world experience and clinical research converge in demonstrating that substance-abusers will continue to use drugs despite repeated adverse outcomes on physical and social well-being. This suggests that a characteristic of abuse may be a reduced ability to inhibit dysfunctional action patterns despite clear evidence of their maladaptivity (Paulus et al., 2002). Indeed, a growing body of behavioral, cognitive, electrophysiological and neuroimaging work suggests that cocaine abusers evidence core insensitivity to internally- and externally-generated signals of error. This insensitivity may reduce the ability to guide adaptive behavioral regulation, and may promote increased perseveration on dysfunctional action patterns, including repetitive drug-taking behavior and comorbid criminality. Despite this growing body of work, the nature of these error-monitoring deficits remains largely undifferentiated, however. Error-monitoring is composed of at least two potentially independent processes: an automatic error detection system that monitors for errors in goal-directed behavior and a less automatic system related to the conscious representation of that error. The majority of work evaluating error-monitoring in substance-dependent populations has focused on error-detection, and has reported consistent impairment. Little is currently understood regarding the state of subjective error-awareness in cocaine abusers, however, which precludes firm conclusions regarding the underlying nature of these error-monitoring deficits. Recent developments in electrophysiological and hemodynamic methods now afford the systematic isolation and evaluation of indices of automatic error-detection and conscious error-awareness, respectively. The present proposal seeks to build off these advances by collecting electrophysiological (EEG) and functional magnetic resonance imaging (fMRI) data within a sample of cocaine abusers (and matched controls), to characterize the integrity of neural circuits underlying their automatic and conscious components of error monitoring, respectively. The Mind Research Network has acquired a state-of-the-art mobile MRI scanner, deployed to various male and female correctional facilities, where epidimiological data indicates that over 65% of inmates suffer from serious substance abuse issues. The deployment of this mobile MRI system thus provides unprecedented access to a population of serious cocaine abusers with comorbid externalizing characteristics. With this access, we propose to collect multimodal (EEG/fMRI) data on 138 incarcerated participants, stratified into two groups: those who do (n = 69) and d not (n = 69) meet criteria for cocaine abuse. Participants will perform a time-estimation task that will afford a carefully controlled evaluation of the integrity of both automatic and concious components of error-monitoring within cocaine abusing individuals. In addition, we plan to follow-up our cocaine abusing participants at 1-year post-incarceration, to evaluate the extent to which error-monitoring integrity predicts future abstinence and relapse rates. The data obtained through this project will serve as the most comprehensive investigation of error monitoring abnormalities within a sample of serious cocaine abusers. The ultimate mission of The Mind Research Network is the development of novel treatment programs for serious psychological and mental disorders, and our group envisions the data collected fom this research as an important step towards future work focused on potential therepeutic and treatment applications.

描述（由申请人提供）：现实世界的经验和临床研究汇聚在证明尽管对身体和社会福祉的不良后果反复不良后果，但滥用物将继续使用药物。这表明滥用的特征可能是抑制功能障碍作用模式的能力，尽管有明确的证据表明其适应不良（Paulus等，2002）。实际上，越来越多的行为，认知，电生理和神经影像学工作表明，可卡因施虐者证明了对内部和外部生成的错误信号的核心不敏感性。这种不敏感的能力可能会降低指导自适应行为调节的能力，并可能促进对功能失调的作用模式的持久性，包括重复的吸毒行为和合并症。尽管工作越来越大，但这些错误监视缺陷的性质仍然很大程度上没有分化。错误监控由至少两个潜在的独立过程组成：一个自动错误检测系统，该系统可监视目标指导行为的错误以及与该错误的有意识表示相关的较少自动系统。评估依赖物质依赖性人群中错误监控的大多数工作集中在错误检测上，并报告了一致的损害。目前，关于可卡因滥用者的主观错误意识的状态几乎没有理解，但是，这排除了关于这些错误监测缺陷的基本性质的公司结论。现在，电生理和血液动力学方法的最新发展提供了分别对自动误差检测和有意识的误差意识指数的系统隔离和评估。本提案旨在通过收集电生理学（EEG）和功能性磁共振成像（fMRI）数据来建立这些进步，并在可卡因滥用器（以及匹配的对照组）样本中进行表征，以表征其自动和有意识的错误监控组件的神经回路的完整性。 Mind Research网络已收购了一个最先进的移动MRI扫描仪，该扫描仪部署到各种男性和女性惩教设施中，该设施的流行病学数据表明，超过65％的囚犯患有严重的药物滥用问题。因此，该移动MRI系统的部署为具有合并外部化特征的严重可卡因施虐者人群提供了前所未有的访问。通过此访问，我们建议收集138名被监禁参与者的多模式（EEG/fMRI）数据，分为两组：那些（n = 69）和D（n = 69）的人（n = 69）符合可卡因滥用的标准。参与者将执行一项时间估计任务，该任务将对可卡因滥用的人的自动和有意义监测的自动组成部分进行精心控制的评估。此外，我们计划在监禁后1年后跟进我们的可卡因滥用参与者，以评估错误监测的完整性预测未来的禁欲和复发率的程度。通过该项目获得的数据将作为严重可卡因施虐者样本中错误监测异常的最全面研究。思维研究网络的最终任务是开发针对严重心理和精神障碍的新型治疗计划，我们的小组设想了收集的数据，这是朝着未来的工作迈出的重要一步，侧重于潜在的企业和治疗应用。