Cognitive Impairment Moderated by Working Memory in Pediatric Partial Epilepsy

小儿部分性癫痫中工作记忆调节的认知障碍

• 批准号: 8112153
• 负责人: Madison Mehalani Berl
• 金额: $ 16.5万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112153
• 关键词: Address; Age; Area; Back; Base of the Brain; Behavioral; Benchmarking; Biological Neural Networks; Biometry; Brain region; Child; Childhood; Clinical; Clinical Research; Cognitive; Cognitive deficits; Color; Commit; Comorbidity; Complex; Cross-Sectional Studies; Development; Diffusion; Emotional; Epilepsy; Fiber; Future; Gender; Impaired cognition; Impairment; Inferior frontal gyrus; Intervention; Language; Lead; Left; Link; Magnetic Resonance Imaging; Measures; Memory; Memory impairment; Mentors; Methodology; Methods; Middle frontal gyrus structure; Mind; Modeling; Nature; Neuroanatomy; Neurobiology; Neurodevelopmental Disorder; Neurologist; Neurophysiology - biologic function; Neuropsychological Tests; Neuropsychology; Neurosciences; Partial Epilepsies; Performance; Predisposition; Process; Recruitment Activity; Research Design; Seizures; Short-Term Memory; Structure; System; Task Performances; Techniques; Testing; Training; United States National Institutes of Health; base; behavioral impairment; career; cognitive neuroscience; executive function; experience; innovation; language processing; neurobehavioral; neuroimaging; neuropsychological; performance tests; skills; social; white matter

DESCRIPTION (provided by applicant): The candidate's application provides the requisite training to establish a clinical research career committed to identify the susceptibility factors in the cognitive comorbidity of epilepsy which is in line with NIH Curing Epilepsy Benchmarks. The candidate is a clinical pediatric neuropsychologist who is proposing to obtain cross-disciplinary training from a neurologist lead co-mentor, neuropsychologist lead co-mentor and distinguished panel of expert mentors and contributors in advanced MRI techniques, developmental cognitive neuroscience, neuropsychology, and biostatistics. This is a cross-sectional study of 50 children with localization related epilepsy who will be matched to healthy controls for age, gender, and SES. Sophisticated neuroscience methods will be used to investigate the functional and structural neuroanatomy of verbal working memory. Working memory, language, and other cognitive domains will be examined by conducting neuropsychological testing, and then all children will participate in functional and structural neuroimaging tasks. It is hypothesized that children with epilepsy will have specific weaknesses in working memory and show greater deviance in the structure and function of brain regions activated. These results will be crucial for developing an informed model of specific brain based cognitive impairments to base and measure future treatments against. This training will enable the candidate to obtain unique cross-disciplinary training using integrated neuroimaging and neuropsychology methods. The candidate will also be well-situated to transition this methodology into other neurodevelopmental disorders over the duration of her career. PUBLIC HEALTH RELEVANCE: Children with epilepsy often experience behavioral and cognitive difficulties. One area of difficulty is executive functioning which is a set of skills important for efficient task performance. This study characterizes the neural network of one aspect of executive functioning, namely working memory, in children with epilepsy using neuroimaging and neuropsychological measures.

描述（由申请人提供）：候选人的申请提供必要的培训，以建立临床研究职业，致力于识别癫痫认知共病的易感因素，符合 NIH 治疗癫痫基准。该候选人是一名临床儿科神经心理学家，提议从神经学家首席联合导师、神经心理学家首席联合导师以及高级 MRI 技术、发育认知神经科学、神经心理学和生物统计学领域的杰出专家导师和贡献者小组获得跨学科培训。这是一项针对 50 名患有定位相关癫痫的儿童的横断面研究，这些儿童将与年龄、性别和社会经济地位 (SES) 方面的健康对照进行匹配。复杂的神经科学方法将用于研究言语工作记忆的功能和结构神经解剖学。工作记忆、语言和其他认知领域将通过神经心理学测试进行检查，然后所有儿童将参与功能和结构神经影像任务。据推测，患有癫痫症的儿童在工作记忆方面会有特定的弱点，并且在激活的大脑区域的结构和功能上表现出更大的偏差。这些结果对于开发特定大脑认知障碍的知情模型至关重要，以作为未来治疗的基础和衡量标准。该培训将使候选人能够利用综合神经影像学和神经心理学方法获得独特的跨学科培训。在她的职业生涯中，候选人也将能够很好地将这种方法转化为其他神经发育障碍。 公共卫生相关性：癫痫儿童经常会出现行为和认知困难。一个困难领域是执行功能，这是一组对于高效执行任务非常重要的技能。这项研究使用神经影像学和神经心理学测量来表征癫痫儿童执行功能的一个方面（即工作记忆）的神经网络。