Neurobehavioral Evaluation Core

神经行为评估核心

基本信息

批准号：
10454196
负责人：
Madison Mehalani Berl
金额：
$ 19.74万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454196
关键词：
Adult Anatomy Animal Behavior Animal Model Animals Anxiety Assessment tool Attention Behavior Behavior assessment Behavioral Behavioral Assay Bioinformatics Biological Biometry Birth Brain Brain Diseases Cells Child Circadian Rhythms Clinical Clinical Research Clinical Trials Cognition Cognitive Collection Communities Complement Complex Computer software Data Storage and Retrieval Database Management Systems Development Diagnosis Disease District of Columbia Doctor of Philosophy Epilepsy Evaluation Face Fetal Alcohol Syndrome Fiber Fostering Functional Magnetic Resonance Imaging Functional disorder Genes Genetic Genomics Genotype Goals Human Human Resources Hypoxia Image Individual Intellectual and Developmental Disabilities Research Centers International Intervention Intervention Studies Investigation Knowledge Language Learning Link Measures Memory Methods Microscopy Mission Modeling Molecular Monitor Moods Motor Motor Activity Mus Myelin Neonatal Brain Injury Neurobiology Neurodevelopmental Disorder Neuropsychology Neurosciences Outcome Pharmacology Phenotype Photometry Physiological Play Prevention Protocols documentation Publications Quality Control Reproducibility Research Personnel Resources Role Sensory Study models Sum System Technology Testing Therapeutic Intervention Therapeutic Trials Tissues Training Translating Treatment Efficacy Vision Visuospatial animal imaging autism spectrum disorder awake behavior test bench to bedside catalyst cognitive function comorbidity cost effective data reduction deep learning digital emotional functioning executive function fetal gene therapy human imaging human model in vivo in vivo monitoring innovation multiphoton imaging neural circuit neural correlate neurobehavior neurobehavioral neurobiological mechanism neuronal circuitry novel optogenetics porcine model pre-clinical preclinical study social social communication success symposium tool translational approach translational potential

项目摘要

Abstract The mission of the Neurobehavioral Evaluation Core (NEC) is to provide District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC) investigators with resources to link underlying biological mechanisms of neurodevelopmental disorders with behavioral and cognitive outcomes as measured in humans and animal models. DC-IDDRC investigators have access to state-of-the-art neurobehavioral assessment tools in humans and cognate animal models to integrate preclinical and clinical studies with genetic and neurobiological analysis of abnormalities associated with IDDs. The NEC enhances efficiency by providing access to expert personnel and testing tools not available to individual labs or investigators. The NEC is comprised of two complementary subcores; the Human Neurobehavior Core (HNEC), directed by Madison Berl, PhD and the Animal Neurobehavior Core (ANEC) directed by Joshua Corbin, PhD. The primary objectives of the NEC are to provide: (a) overall vision, planning, training and implementation of human behavioral tasks and complementary behavioral assessments in cognate animal models of human neurodevelopmental disorders, (b) to develop, maintain and implement state of the art platforms and resources for human and animal neurobehavior investigation and across multiple animal models, (c) to collaborate and integrate with all DC-IDDRC cores to unravel neurobiological mechanisms from genes to circuits to behaviors underlying a host of IDDs, (d) to facilitate the conduct of robust, reproducible and rigorous scientific investigation with a high impact on the field of neuroscience and IDDs, (e) to disseminate findings broadly to the scientific and academic communities via publications, presentations and international conference forums, (f) to use the knowledge gained from human and animal behavior assessments to test and translate findings from the bench to the bedside. These goals will be achieved in the following specific aims: (1) To define the consequences of IDDs on human neurobehavior and animal behavioral correlates, (2) To expand and implement the use state-of-the-art technologies for human and animal behavior assessment and (3) To develop/identify longitudinal assessment paradigms that are sensitive to change in IDDs in humans and animal models and that will be critical for monitoring success of intervention studies. The NEC has long standing strengths in the analysis of humans and animal models of a number of neurodevelopmental disorders including autism spectrum disorders, epilepsy, fetal alcohol syndrome and fetal/neonatal brain injury. Over the past years, our highly successful animal model studies have elucidated cellular and molecular mechanisms underlying physiological and behavioral abnormalities in these prevalent conditions, while our human investigation has linked atypical trajectories of brain development to their structural and behavioral correlates. Building on these strengths, our increasing variety and sophisticated human and animal behavioral assessment platforms will also be widely applicable across a host of neurodevelopmental conditions.

抽象的神经行为评估核心 (NEC) 的使命是为哥伦比亚特区提供智力和发育障碍研究中心 (DC-IDDRC) 的研究人员拥有将潜在的联系起来的资源神经发育障碍的生物学机制以及所测量的行为和认知结果在人类和动物模型中。 DC-IDDRC 研究人员可以获得最先进的神经行为学数据人类和同源动物模型的评估工具，将临床前和临床研究与与 IDD 相关的异常的遗传和神经生物学分析。 NEC 通过以下方式提高效率提供个别实验室或研究人员无法获得的专家人员和测试工具。这 NEC 由两个互补的子核组成；人类神经行为核心（HNEC），由 Madison Berl 博士和 Joshua Corbin 博士指导的动物神经行为核心 (ANEC)。初级 NEC 的目标是提供： (a) 总体愿景、规划、培训和实施人类同源动物模型中的行为任务和补充行为评估神经发育障碍，(b) 开发、维护和实施最先进的平台和资源用于人类和动物神经行为研究以及多种动物模型，(c) 合作和与所有 DC-IDDRC 核心集成，揭示从基因到电路到行为的神经生物学机制作为许多 IDD 的基础，(d) 促进开展稳健、可重复和严格的科学研究对神经科学和 IDD 领域具有重大影响的调查，(e) 广泛传播研究结果通过出版物、演讲和国际会议论坛向科学界和学术界展示， (f) 利用从人类和动物行为评估中获得的知识来测试和转化结果从长凳到床边。这些目标将通过以下具体目标来实现：（1）定义 IDD 对人类神经行为和动物行为相关的影响，(2) 扩展和使用最先进的技术进行人类和动物行为评估以及 (3) 开发/确定对人类 IDD 变化敏感的纵向评估范式和动物模型，这对于监测干预研究的成功至关重要。 NEC 有在分析多种神经发育的人类和动物模型方面具有长期的优势疾病包括自闭症谱系障碍、癫痫、胎儿酒精综合症和胎儿/新生儿脑损伤。在过去的几年里，我们非常成功的动物模型研究阐明了细胞和分子在这些普遍情况下，生理和行为异常的机制，而我们的人类研究已将大脑发育的非典型轨迹与其结构和行为联系起来相关。基于这些优势，我们的人类和动物行为日益多样化和复杂评估平台还将广泛适用于许多神经发育状况。