REGULATION OF THE SIGNALING PHOSPHOLIPID, PHOSPHATIDYLINOSITOL 3,5 BIS PHOSPHATE

信号磷脂、磷脂酰肌醇 3,5 二磷酸酯的调节

• 批准号: 8171245
• 负责人: Lois S Weisman
• 金额: $ 0.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171245
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Defect; Funding; Generations; Genetic; Goals; Grant; Institution; Membrane Protein Traffic; Minor; Nervous System Physiology; Pathway interactions; Phosphatidylinositols; Phospholipids; Phosphorylation; Phosphorylation Site; Polyphosphates; Proteins; Regulation; Research; Research Personnel; Resources; Risk Factors; Signal Transduction; Source; United States National Institutes of Health; inorganic phosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phosphatidylinositol polyphosphates (PPIs) have recently emerged as key regulators of membrane trafficking pathways. We recently discovered that the PPI, phosphatidylinositol 3,5 bis phosphate (PI3,5)P2, is particularly critical for normal function of the nervous system. We found that very minor defects in the generation of (PI3,5)P2 are a significant risk factor in ALS. Moreover we recently found that the five proteins known to regulate PI3,5P2 are phosphorylated. The overall goal of this project is to determine the phosphorylation sites, and then to use a genetic approach to determine how phosphorylation regulates PI3,5P2 levels

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 磷脂酰肌醇多磷酸（PPI）最近已成为膜运输途径的关键调节剂。我们最近发现 PPI（磷脂酰肌醇 3,5 二磷酸 (PI3,5)P2）对于神经系统的正常功能特别重要。 我们发现 (PI3,5)P2 生成过程中的微小缺陷是 ALS 的一个重要风险因素。 此外，我们最近发现已知调节 PI3、5P2 的五种蛋白质被磷酸化。 该项目的总体目标是确定磷酸化位点，然后利用遗传方法确定磷酸化如何调节 PI3,5P2 水平