Southeast Asia Malaria Research Center

东南亚疟疾研究中心

基本信息

批准号：
8500136
负责人：
LIWANG CUI
金额：
$ 219.63万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8500136
关键词：
Accounting Address Anti-malarial drug resistance Antibodies Area Artemisinins Biological Assay Biology Blood Circulation Breeding Cambodia China Chloroquine resistance Collaborations Communities Country Detection Development Diagnosis Diagnostic Disease Drug Formulations Drug resistance Drug usage Ecology Ensure Environmental Impact Epidemiology Face Fostering Genetic Genomics Goals Health Heterogeneity Incidence Institution International Knowledge Laos Life Malaria Measurement Measures Medical Methods Modeling Molecular Molecular Biology Molecular Epidemiology Monitor Monoclonal Antibodies Morbidity - disease rate Multi-Drug Resistance Myanmar Parasite resistance Parasites Pattern Pharmaceutical Preparations Phase Plasmodium falciparum Plasmodium vivax Population Population Biology Prevalence Province Public Health Pyrimethamine-Sulfadoxine Recording of previous events Research Research Personnel Research Training Resistance Resources Role Scientist Services Site Southeastern Asia System Thailand Training Programs Triad Acrylic Resin Tribes Vietnam artemisinine authority base burden of illness chemotherapy cost effective data management design drug quality epidemiology study ethnic minority population forest genome-wide improved in vivo innovation meetings mortality neglect programs resistance mechanism socioeconomics tool transmission process vector vector control

项目摘要

Malaria control in Southeast Asia faces a number of serious challenges that require coordinated and focused efforts. The uneven distribution of malaria incidences and limited resources call for the development of adaptable and cost-effective control strategies. Knowledge gaps in malaria epidemiology, vector biology and parasite genetics hinder the development of effective control measures. Emerging resistance of parasites to artemisinins and circulation of counterfeit/substandard artemisinin drugs that threaten regional and global malaria control campaigns demand close monitoring, and development of adequate countermeasures. To address these challenges, this ICEMR program brings together outstanding institutions in the U.S., Thailand, Myanmar and China, where internationally recognized investigators have a history of collaborations in malaria research and training. In strategically selected study sites of Myanmar, China, and Thailand that target the most impoverished areas in this region, this consortium will study urgent scientific questions important to this neglected region that are also pertinent to global malaria control. This program has three cores (administrative, data management, and molecular biology) and four scientific projects. Project 1 "Malaria epidemiology in Southeast Asia: Intra- and inter-country dynamics" will develop an accurate measurement of heterogeneity of the disease burden, and provide essential epidemiological information for developing and evaluating integrated malaria control strategies in multiple sites with varying epidemiological conditions. Project 2 "The malaria vectorial system and new vector control tools in Southeast Asia" aims to understand the ecology of malaria vectors in this region and develop innovative malaria transmission surveillance and control tools. Project 3 "Antimalarial drug resistance in P. falciparum" aims to elucidate the mechanism of artemisinin resistance using a high-throughput, genome-wide analytic tool and parasite populations from areas where artemisinin resistance is emerging. Project 4 "Development of monoclonal antibody-based assays for detection and quantification of artemisinin derivatives" will develop antibody based methods for quantification of artemisinins under field conditions for monitoring drug quality.

东南亚的疟疾控制面临许多严重的挑战，需要协调和集中的努力。疟疾发病率和有限的资源的分布不均匀，要求开发适应性和成本效益的控制策略。疟疾流行病学，载体生物学和寄生虫遗传学的知识差距阻碍了有效控制措施的发展。寄生虫对青蒿素的新兴耐药性以及威胁区域和全球疟疾控制运动的伪造/不合格的阿丁蛋白药物的循环，需要密切监测，并发展适当的对策。为了应对这些挑战，该ICEMR计划汇集了美国，泰国，缅甸和中国的杰出机构，国际认可的调查人员在疟疾研究和培训方面拥有合作的历史。在针对该地区最贫困地区的缅甸，中国和泰国的战略性选择的研究地点中，该财团将研究对这个被忽视的地区与全球疟疾控制有关的紧急科学问题。该计划具有三个核心（行政，数据管理和分子生物学）和四个科学项目。项目1“东南亚的疟疾流行病学：国内和国际动态”将对疾病负担的异质性进行准确的衡量，并为在多个部位的多个地点开发和评估具有不同的流行病学条件的基本疟疾控制策略提供必不可少的流行病学信息。项目2“东南亚的疟疾媒介系统和新的媒介控制工具”旨在了解该地区疟疾媒介的生态，并开发创新的疟疾传播监视和控制工具。项目3“恶性疟原虫中的抗疟疾耐药性”旨在使用高通量，全基因组的分析工具和寄生虫种群来阐明青蒿素耐药性的机制，并从促进青蒿素耐药性的地区。项目4“基于单克隆抗体检测和定量青蒿素衍生物的开发”将开发基于抗体的方法，用于在田间条件下定量青蒿素来监测药物质量。