Harnessing microRNAs within miR-17-92 cluster for autoimmune intervention

利用 miR-17-92 簇内的 microRNA 进行自身免疫干预

• 批准号: 8312018
• 负责人: Qijing Li
• 金额: $ 38.37万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8312018
• 关键词: Animals; Antigens; Apoptosis; Autoantigens; Autoimmune Diseases; Autoimmune Process; Biology; CD4 Positive T Lymphocytes; Cell Death; Cell Lineage; Cell physiology; Cells; Cellular biology; Chemical Engineering; Complex; Data; Development; Elements; Engineering; Enhancers; Epigenetic Process; Functional RNA; Gene Cluster; Genes; Goals; Immune; Immune Tolerance; Immune response; Immune system; Immunotherapy; Individual; Intervention; Knowledge; Lymphoid; Major Histocompatibility Complex; Mediating; MicroRNAs; Molecular; Oligonucleotides; Oncogenic; Organ; Outcome; PTEN gene; Pathway interactions; Pattern; Peptides; Phosphoric Monoester Hydrolases; Phosphotransferases; Plants; Play; Process; Proteins; Reaction; Regulation; Regulatory T-Lymphocyte; Research; Role; Signal Transduction; T cell differentiation; T cell regulation; T cell response; T-Cell Receptor; T-Lymphocyte; Therapeutic; Therapeutic Intervention; Uncertainty; Virus; autoreactive T cell; base; combat; immunoregulation; in vivo; inhibitor/antagonist; member; neoplastic cell; novel; novel therapeutics; response; scaffold; tumorigenesis

项目成果

miR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation.

miR-17-92 簇靶向磷酸酶和张力蛋白同源性以及 Ikaros 家族锌指 4，以促进 TH17 介导的炎症。

• 发表时间: 2014-05-02
• 作者: Liu, Si;Jiang, Shan;Li, Chaoran;Zhang, Baojun;Li, Qi
• 通讯作者: Li, Qi

T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.

T 细胞受体 (TCR) 和转化生长因子β (TGF-β) 信号汇聚在 DNA (胞嘧啶-5)-甲基转移酶上，控制叉头盒蛋白 3 (foxp3) 位点甲基化和诱导调节性 T 细胞分化。

• 发表时间: 2013-06-28
• 作者: Li, Chaoran;Ebert, Peter J R;Li, Qi
• 通讯作者: Li, Qi