Modeling of Collateral Perfusion in the Ischemic Brain

缺血性脑部侧支灌注的建模

• 批准号: 8337308
• 负责人: DAVID SIGMUND LIEBESKIND
• 金额: $ 18.79万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337308
• 关键词: Academic achievement; Achievement; Acute; Address; Angiography; Arteries; Behavior assessment; Blood - brain barrier anatomy; Blood Vessels; Blood flow; Brain; Brain Ischemia; Caring; Catheters; Cerebrovascular Circulation; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Communication; Communities; Computer software; Data; Development; Educational Curriculum; Effectiveness; Ensure; Environment; Etiology; Faculty; Fostering; Funding; Future; Generations; Genetic; Goals; Grant; Growth; Imaging technology; Individual; Infarction; Influentials; Institutes; Internet; Ischemic Stroke; Knowledge; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Medical; Mentors; Mentorship; Methodology; Microcirculation; Mid-Career Clinical Scientist Award (K24); Modeling; Neurologic; Neurological outcome; Neurology; Neurosciences; Outcome; Outcome Measure; Outcomes Research; Perfusion; Public Health; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Technics; Research Training; Resources; Role; Scientist; Software Tools; Stroke; Structure; Techniques; Testing; Therapeutic; Tissues; Training; Training Programs; Translational Research; Variant; Veins; Venous; Work; X-Ray Computed Tomography; acute stroke; base; blood perfusion; career; career development; clinically relevant; hemodynamics; improved; innovation; lectures; meetings; model development; nervous system disorder; neuroimaging; novel; patient oriented research; pressure; prognostic; programs; prospective; responsible research conduct; skills; tool; treatment strategy; trend; web site

PROJECT SUMMARY/ABSTRACT Common neurological disorders pose an increasingly formidable public health burden that requires studies of underlying mechanisms and ample effort of patient-oriented research (POR) investigators. This midcareer application's long-term mentoring program goal is to train leading young translational scientists from diverse neurologic subspecialties in POR, redressing the mentoring gap in neurology POR that threatens future progress, and the long-term research project goal is to increase understanding of collateral perfusion in stroke. An innovative mentoring infrastructure for selected residents, clinical fellows and junior faculty is proposed with content mentors in neurologic subspecialties and an overall POR mentor. Mentoring aims include 1) establishing departmental mentoring infrastructure, one-on-one mentoring, trainee research, career development and website resources; 2) creating new courses on neurology clinical and translational research and scientific communications; and 3) continually enhancing faculty mentorship skills. The impact of this mentoring program at UCLA will be tracked with specific outcome measures to ensure achievement of trainee and overall program milestones. This K24 award will help achieve departmental long-term goals to enhance POR across neurologic subspecialties, establish formal neurology POR mentorship, stimulate independent research of trainees and foster an inspiring intellectual environment to increase the number of future neurology POR investigators. This integrated approach to neurology POR training also benefits from a focused research strategy to develop a model of collateral perfusion for content mentoring in stroke, a project that provides mentoring opportunities over a diverse spectrum of POR techniques. Novel neuroimaging and angiography approaches will be used to develop and validate a regional model of collateral perfusion using pressure differentials in arteries, tissue, and veins to predict tissue fate and neurological outcomes in acute ischemic stroke. This clinically relevant work on an important topic in stroke care will enhance understanding of collateral perfusion, including the distinct contributions of arterial and venous segments of the cerebral circulation. In addition to the advancement of scientific knowledge and provision of mentoring opportunities, a tangible resulting product will be a software tool to enhance prediction of tissue fate and neurological outcomes in acute stroke across diverse causes of brain ischemia.

项目摘要/摘要 常见的神经系统疾病带来了越来越强大的公共卫生负担，需要研究 基本机制和面向患者的研究（POR）研究人员的努力。这个中级护理 应用程序的长期指导计划的目标是培训来自多样化的年轻翻译科学家 POR中的神经科亚专业，纠正了威胁未来的神经病学中的指导差距 进步和长期研究项目的目标是增加对中风副灌注的理解。 提议针对选定居民，临床研究员和初级教师的创新指导基础设施 神经系统专科和整体指导者的内容导师。指导目标包括1） 建立部门指导基础设施，一对一指导，学员研究，职业 开发和网站资源； 2）创建有关神经病学临床和转化研究的新课程 和科学沟通； 3）不断提高教师指导能力。这个影响 在UCLA的指导计划将通过具体的结果指标进行跟踪，以确保实现受训者的成就 和整体计划里程碑。这项K24奖将有助于实现部门的长期目标以增强 跨神经系统专科，建立正式的神经病学指导，刺激独立 对学员的研究并培养一个鼓舞人心的知识环境，以增加未来神经病学的数量 POR调查人员。这种综合神经病学培训方法也受益于一项重点研究 制定副外灌注模型以进行中风的内容指导的策略，该项目提供 通过各种POR技术的指导机会。新颖的神经影像学和血管造影 方法将用于使用压力开发和验证附带灌注的区域模型 动脉，组织和静脉的差异，以预测急性缺血性的组织命运和神经系统效果 中风。这项临床上有关中风护理中重要主题的临床相关工作将增强对抵押品的理解 灌注，包括大脑循环的动脉和静脉片段的不同贡献。在 除了进步科学知识和指导机会的提供，这是一个有形的 最终的产品将是增强急性预测组织命运和神经系统结果的软件工具 脑部缺血原因的中风。