International Symposium on Collaterals to the Brain

大脑络脉国际研讨会

• 批准号: 8458827
• 负责人: DAVID SIGMUND LIEBESKIND
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458827
• 关键词: Acute; Acute Disease; Address; Adult; Anatomy; Area; Attention; Blood Vessels; Blood flow; Books; Brain; Brain Diseases; Cerebrovascular Circulation; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Collaborations; Collateral Circulation; Development; Diagnosis; Disabled Persons; Disease; Education; Ensure; Evaluation; Event; Fertilization; Functional disorder; Future; Genetic; Goals; Health; Hemorrhage; Image; Infarction; Influentials; International; Ischemia; Ischemic Stroke; Journals; Knowledge; Mainstreaming; Measurable; Mentors; Methodology; Minority; National Institute of Neurological Disorders and Stroke; Outcome; Participant; Perfusion; Plant Roots; Postdoctoral Fellow; Prevention; Progress Review Group; Public Health; Publications; Publishing; Questionnaires; Recording of previous events; Request for Proposals; Research; Research Personnel; Research Priority; Risk; Role; Stenosis; Stroke; Structure; Students; Therapeutic; Translational Research; United States National Institutes of Health; Woman; Work; acute stroke; base; brain tissue; career; clinical practice; design; disability; hemodynamics; improved; innovation; insight; interdisciplinary approach; lectures; meetings; multidisciplinary; next generation; novel; outcome forecast; parity; programs; stroke recovery; success; symposium

DESCRIPTION (provided by applicant): The International Symposium on Collaterals to the Brain is a multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. This proposal requests partial support for a conference with broad, long-term objectives that will detail current status of knowledge on collaterals, identify gaps, and develop a roadmap for the next 5 years of research in this field. Mentoring junior investigators in this endeavor is a major emphasis of this first meeting devoted to collaterals to the brain. Collaterals have recently become a mainstream focus of stroke research, yet a forum has never been established to dedicate attention to this top research priority of NINDS. The aims of this conference will convene over 30 leading experts to cover critical aspects of this burgeoning field, with a total of 200 participants for a 2-day conference in an academic setting. The confirmed program is structured into 5 sessions covering the history and translational research on collaterals, chronic role of collaterals, imaging features, acute stroke aspects, and considerations of clinical trial design for collateral therapeutics. A seminar and panel discussion is devoted to issues germane to mentoring the next generation of investigators in collateral perfusion. Publication plans include a detailed roadmap on next steps in research on collaterals. Every effort will be made to encourage participation by postgraduate students and postdocs, to have parity in the numbers of women, and to include minorities and persons with disabilities. Measurable outcomes of conference goals will be assessed, evaluating the impact of this symposium on the NIH commitment to new investigators, translational stroke research and the NINDS PRG priority for studies on collateral perfusion. The significance of this proposal is underscored by the establishment of a framework for novel research collaborations, cultivation of new investigators and improved clinical practice in this area, through a unique event, associated interactions and subsequent roadmap publication. The health relatedness of this proposal is rooted in the discussions and research initiatives that will help address key prioritie on the influential role of collaterals in the devastating disorder of stroke. PUBLIC HEALTH RELEVANCE: The International Symposium on Collaterals to the Brain is a 2-day multidisciplinary scientific conference focused on collateral perfusion in acute and chronic neurovascular disorders. Leading experts will evaluate current knowledge on the role of collaterals, identify gaps, address mentoring issues of future innovators in this area, and publish a detailed roadmap for the next 5 years of research on collateral perfusion. Understanding the beneficial effects of collaterals in acute stroke and intracranial stenoses may accelerate the development of collateral therapeutics to restore blood flow in stroke, the leading cause of adult disability in the US and a key priority for improving public health.

描述（由申请人提供）：大脑抵押品的国际研讨会是一次多学科科学会议，重点介绍了急性和慢性神经血管疾病的附带灌注。该提案要求为一次会议提供部分支持，该会议具有广泛的长期目标，该会议将详细介绍有关抵押品知识的当前状态，识别差距，并为在该领域的未来5年研究中开发路线图。在这项工作中指导初级调查人员是这次专门致力于大脑的第一次会议的重点。抵押品最近已成为中风研究的主流重点，但是从未建立过一个论坛来专门关注Ninds的这一主要研究优先事项。这次会议的目的将召集30多名领先的专家，以涵盖这个新兴领域的关键方面，共有200名参与者参加了在学术环境中为期2天的会议。确认的程序构成了5个会议，涵盖了侧支的历史和翻译研究，侧支的慢性作用，成像特征，急性中风方面以及侧支疗法临床试验设计的考虑。研讨会和小组讨论 专门针对Demane的问题来指导下一代研究人员的附带灌注。出版计划包括有关侧支研究的下一步的详细路线图。将尽一切努力鼓励研究生和博士后，以妇女人数均等，并包括少数民族和残疾人。将评估会议目标的可衡量结果，以评估本研讨会对NIH对新研究者的承诺，转化中风研究和NINDS PRG的影响的影响，以实现侧支灌注研究。通过建立新的研究合作，新研究人员的培养和改善该领域的临床实践的框架，通过独特的事件，相关的互动以及随后的路线图出版物来建立该提案的重要性。该提案的健康相关性植根于讨论和研究计划，这些计划将有助于解决侧支在毁灭性障碍中的有影响力作用的关键优先点。 公共卫生相关性：国际大脑抵押品研讨会是为期2天的多学科科学会议，重点是急性和慢性神经血管疾病的附带灌注。领先的专家将评估有关抵押品作用的当前知识，确定差距，解决该领域未来创新者的指导问题，并发布 接下来的5年有关附带灌注研究的详细路线图。了解抵押品在急性中风和颅内狭窄中的有益作用可能会加速副外疗法以恢复中风中的血液流量，这是美国成人残疾的主要原因，也是改善公共卫生的关键优先事项。