CENTER FOR CANCER SIGNALING NETWORKS

癌症信号网络中心

• 批准号: 8364911
• 负责人: Walter J Atwood
• 金额: $ 113.32万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364911
• 关键词: Bioinformatics; Cancer Center; Centers of Research Excellence; Communities; Computational Molecular Biology; Core Facility; Cost Sharing; Faculty; Fees; Fostering; Funding; Genomics; Goals; Grant; Image; Individual; Malignant Neoplasms; National Center for Research Resources; Pilot Projects; Positioning Attribute; Principal Investigator; Research; Research Infrastructure; Research Personnel; Resources; Rhode Island; Services; Signal Transduction; Solid; Source; Transgenic Mice; Transgenic Organisms; Translating; United States National Institutes of Health; Universities; cost; improved; programs; public health relevance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent support in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed. PUBLIC HEALTH RELEVANCE (provided by applicant): The research resources that are proposed in this application will foster a broad range of cancer related research programs at Brown and its affiliates in the State of Rhode Island. The state of the art core facilities in genomics and transgenics are critical to maintaining our position of excellence in the scientific community.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 描述（由申请人提供）：我们的 III 型过渡 COBRE 的主要目标是为布朗大学社区和东北部的附属中心提供最先进的基因组和转基因核心服务，同时准备在未来五年内过渡到独立支持年。该中心在 II 型 COBRE 支持下开发的科学主题是癌症信号网络。这一总体科学主题将继续下去，但我们作为一个中心准备为比 II 型 COBRE 最初支持的更广泛的科学项目提供研究基础设施。与 III 型 COBRE 相关的试点项目机制将用于集中教师群体的协作努力，重点关注重大科学问题，这些问题可以立即转化为多 PI 和/或项目项目应用。最初提出的研究核心是小鼠转基因、成像、基因组学和生物信息学。前三个设施是从 I 型 COBRE 延续下来的，而后者则是作为新的核心设施建立的。生物信息学核心在发展成为一个独立中心（计算分子生物学中心）时仅得到 II 型 COBRE 的短暂支持。成像核心也脱离了 COBRE 支持，现在作为独立设施运行。成像核心呈指数级增长，是布朗大学和该州研究人员的主要资源。我们拥有利用 COBRE 资源开发坚实的研究核心的记录，其科学重点使他们能够独立于该机制。我们请求支持的剩余两个核心很快就受到罗德岛州科学界的更加依赖。我们将继续改进这些核心，使其能够在需要时通过用户费用、个人和项目类型的赠款支持以及大学费用分摊的组合来独立支持。 公共卫生相关性（由申请人提供）：本申请中提出的研究资源将促进布朗大学及其在罗德岛州的附属机构开展广泛的癌症相关研究项目。最先进的基因组学和转基因核心设施对于保持我们在科学界的卓越地位至关重要。