Center for Cancer Signaling Networks

癌症信号网络中心

• 批准号: 8115529
• 负责人: Walter J Atwood
• 金额: $ 113.32万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115529
• 关键词: Center; Cancer; Signaling; Networks

DESCRIPTION (provided by applicant): The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent support in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed.

描述（由申请人提供）：我们的 III 型过渡 COBRE 的主要目标是为布朗大学社区和东北部的附属中心提供最先进的基因组和转基因核心服务，同时准备在未来五年内过渡到独立支持年。该中心在 II 型 COBRE 支持下开发的科学主题是癌症信号网络。这一总体科学主题将继续下去，但我们作为一个中心准备为比 II 型 COBRE 最初支持的更广泛的科学项目提供研究基础设施。与 III 型 COBRE 相关的试点项目机制将用于集中教师群体的协作努力，重点关注重大科学问题，这些问题可以立即转化为多 PI 和/或项目项目应用。最初提出的研究核心是小鼠转基因、成像、基因组学和生物信息学。前三个设施是从 I 型 COBRE 延续下来的，而后者则是作为新的核心设施建立的。生物信息学核心在发展成为一个独立中心（计算分子生物学中心）时仅得到 II 型 COBRE 的短暂支持。成像核心也脱离了 COBRE 支持，现在作为独立设施运行。成像核心呈指数级增长，是布朗大学和该州研究人员的主要资源。我们拥有利用 COBRE 资源开发坚实的研究核心的记录，其科学重点使他们能够独立于该机制。我们请求支持的剩余两个核心很快就受到罗德岛州科学界的更加依赖。我们将继续改进这些核心，使其能够在需要时通过用户费用、个人和项目类型的赠款支持以及大学费用分摊的组合来独立支持。

项目成果

Phylogenomic analyses of deep gastropod relationships reject Orthogastropoda.

深层腹足动物关系的系统基因组分析拒绝直腹足动物。

• 发表时间: 2014
• 作者: Zapata, Felipe;Wilson, Nerida G;Howison, Mark;Andrade, Sónia C S;Jörger, Katharina M;Schrödl, Michael;Goetz, Freya E;Giribet, Gonzalo;Dunn, Casey W
• 通讯作者: Dunn, Casey W

Characterization of differential transcript abundance through time during Nematostella vectensis development.

Nematostella vectensis 发育过程中转录本丰度随时间变化的特征。

• 发表时间: 2013-04-19
• 影响因子: 4.4
• 作者: Helm, Rebecca Rae;Siebert, Stefan;Tulin, Sarah;Smith, Joel;Dunn, Casey William
• 通讯作者: Dunn, Casey William

Phylogenomic Analyses Support Traditional Relationships within Cnidaria.

系统基因组分析支持刺胞动物内的传统关系。

• 发表时间: 2015
• 影响因子: 3.7
• 作者: Zapata, Felipe;Goetz, Freya E;Smith, Stephen A;Howison, Mark;Siebert, Stefan;Church, Samuel H;Sanders, Steven M;Ames, Cheryl Lewis;McFadden, Catherine S;France, Scott C;Daly, Marymegan;Collins, Allen G;Haddock, Steven H D;Dunn, Casey W;Cartw
• 通讯作者: Cartw

Improved phylogenetic resolution within Siphonophora (Cnidaria) with implications for trait evolution.

管毛纲（Cnidaria）内系统发育分辨率的提高对性状进化具有影响。

• 发表时间: 2018
• 影响因子: 4.1
• 作者: Munro, Catriona;Siebert, Stefan;Zapata, Felipe;Howison, Mark;Damian;Church, Samuel H;Goetz, Freya E;Pugh, Philip R;Haddock, Steven H D;Dunn, Casey W
• 通讯作者: Dunn, Casey W