Center for Cancer Signaling Networks

癌症信号网络中心

• 批准号: 8251146
• 负责人: Walter J Atwood
• 金额: $ 109.13万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8251146
• 关键词: Bioinformatics; Biological Preservation; Cancer Center; Centers of Research Excellence; Collaborations; Communities; Computational Molecular Biology; Computers; Core Facility; Cost Sharing; Cryopreservation; Derivation procedure; Doctor of Philosophy; Embryo; Ensure; Faculty; Fees; Fostering; Funding; Gene Targeting; Genomics; Goals; Grant; Image; Individual; Instruction; Link; Malignant Neoplasms; Mentors; Mus; Pilot Projects; Positioning Attribute; Production; Request for Applications; Research; Research Infrastructure; Research Personnel; Resources; Rhode Island; Running; Services; Signal Transduction; Solid; Transgenic Mice; Transgenic Mouse Facility; Transgenic Organisms; Translating; Universities; Work; base; career; cost effective; cryogenics; improved; meetings; programs; tool; web site

The major goal of our type III transitional COBRE is to provide state of the art genomic and transgenic core services to the Brown University community and affiliated centers in the Northeast while preparing to transition to independent suport in the next five years. The scientific theme of the Center developed with type II COBRE support was cancer signaling networks. This general scientific theme will be continued but we as a center are poised to provide the research infrastructure for a wider range of scientific projects than were supported initially in the type II COBRE. The pilot project mechanism associated with the type III COBRE will be used to nucleate collaborative efforts by groups of faculty focusing on significant scientific problems that can immediately translate into multi-PI and/or program project applications. The research cores originally proposed were Mouse Transgenics, Imaging, Genomics and Bioinformatics. The first three carried over from the type I COBRE while the latter was established as a new core facility. The Bioinformatics core was only briefly supported by the type II COBRE as it evolved into an independent center (Center for Computational Molecular Biology). The Imaging core was also graduated from COBRE support and now functions as an independent facility. The imaging core has grown exponentially and is a major resource for investigators at Brown and in the state. We have a track record of using COBRE resources to develop solid research cores whose scientific focus allows them to achieve independence from this mechanism. Our remaining two cores for which we are requesting support are quickly becoming more heavily relied on by the scientific community here in Rhode Island. We will continue to improve these cores to the point where they can be independently supported by a combination of user fees, individual and program-type grant support, and University cost-sharing when needed.

我们的 III 型过渡 COBRE 的主要目标是提供最先进的基因组和转基因核心 为布朗大学社区和东北部的附属中心提供服务，同时准备 未来五年内过渡到独立支持。该中心的科学主题是随着 II 型 COBRE 支持是癌症信号网络。这个一般性的科学主题将继续下去，但是 我们作为一个中心准备为更广泛的科学项目提供研究基础设施 最初在 II 型 COBRE 中得到支持。与第三类相关的试点项目机制 COBRE 将用于核心化教师群体的协作努力，重点关注重大科学问题 可以立即转化为多 PI 和/或程序项目应用程序的问题。研究 最初提出的核心是小鼠转基因、成像、基因组学和生物信息学。前三名 继承自 I 型 COBRE，而后者被建立为新的核心设施。这 生物信息学核心在发展为独立中心时仅得到 II 型 COBRE 的短暂支持 （计算分子生物学中心）。成像核心也获得了 COBRE 支持 现在作为一个独立的设施运作。成像核心呈指数增长，是一个主要的 为布朗大学和该州的调查人员提供资源。我们有使用 COBRE 资源的记录 开发坚实的研究核心，其科学重点使他们能够独立于此 机制。我们请求支持的剩余两个核心正在迅速变得更加强大 受到罗德岛州科学界的高度依赖。我们将不断完善这些核心 以至于他们可以通过使用费、个人费用和个人费用的组合来独立支持 计划类型的赠款支持，以及需要时的大学费用分摊。