HCC Ovarian Cancer SPORE

HCC 卵巢癌孢子

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT – OVERALL Ovarian cancer (OvCa) has the third highest mortality to incidence ratio and is the fifth leading cause of cancer death in American women. The typical disease course of a patient with OvCa spans four and a half years from the time of diagnosis to death. During the course of patient care, acquired and innate resistance to our most effective and promising therapies, such as chemotherapy, PARP inhibitor therapy, and immunotherapy, drives disease progression. The overall goal of the UPMC Hillman Cancer Center (HCC) OvCa SPORE is to prevent and/or overcome therapeutic resistance to improve patient survival. Each of the SPORE’s three Projects evolved from the innovative concepts and findings of SPORE investigators. Each project involves a clinical trial with a new agent. In addition, each project, through complementary investigator expertise, incorporates critical translational aims to identify patients most likely to respond to therapy. Project 1 will assess the ability of inhibitors of the epigenetic regulator EZH2 to prevent/overcome OvCa stromal progenitor cell-driven resistance to platinum-based chemotherapy. Project 2 will determine whether BET inhibitors, which downregulate critical DNA repair and cell cycle checkpoint proteins, can reverse resistance to PARP inhibitors. Project 3 will test whether inhibitors of the hedgehog signaling pathway, which drives tumor immune exclusion, can improve OvCa patient response to immune checkpoint inhibitor therapy. The HCC OvCa SPORE will include a Career Enhancement Program (CEP) and Developmental Research Program (DRP) in order to both encourage early career investigators to enter the field of translational OvCa research and engage more established investigators in OvCa research. The CEP and the DRP, which are cost-shared and proactive at providing research funding to investigators from under-represented minority groups, will provide a pipeline of potential future SPORE Projects. All SPORE, CEP, and DRP Projects will be receive fiscal and scientific oversight from an Administrative Core and support from two shared resource cores. The Translational Pathology Core will collect, annotate, archive, and distribute biospecimens and clinical data derived from the more than 300 HCC OvCa patients seen each year. It will also develop new preclinical experimental models that behave more like human OvCa. The Biostatistics and Bioinformatics Core will aid in design and analysis of all studies, including ‘omic’ technologies that can provide molecular and spatial characterization of individual cells within a tumor. The SPORE Projects will also be supported by established and new collaborators who are internal and external to HCC. Combined, the SPORE projects, CEP, DRP, and cores are positioned, together with our vertical collaborators, to improve the outcomes of patients with ovarian cancer. The findings generated by the SPORE will be advanced through further collaboration and future non-SPORE funding.
项目概要/摘要——总体 卵巢癌 (OvCa) 的死亡率与发病率之比排名第三,是第五大癌症原因 美国女性 OvCa 患者的典型病程长达四年半。 从诊断到死亡的过程中,我们最大的后天和先天的抵抗力。 有效且有前景的疗法,如化疗、PARP 抑制剂疗法和免疫疗法,推动 UPMC Hillman 癌症中心 (HCC) OvCa SPORE 的总体目标是预防疾病进展。 和/或克服治疗耐药性以提高患者的生存率。 每个项目均由 SPORE 研究人员的创新概念和发现演变而来。 此外,每个项目都通过互补的调查员专业知识,纳入了关键的内容。 转化的目的是确定最有可能对治疗产生反应的患者,项目 1 将评估患者的能力。 表观遗传调节因子 EZH2 的抑制剂可预防/克服 OvCa 基质祖细胞驱动的耐药性 项目 2 将确定 BET 抑制剂是否会下调关键作用。 DNA 修复和细胞周期检查点蛋白可以逆转 PARP 抑制剂的耐药性,项目 3 将进行测试。 驱动肿瘤免疫排斥的刺猬信号通路抑制剂是否可以改善 OvCa 患者对免疫检查点抑制剂治疗的反应 HCC OvCa SPORE 将包括职业生涯。 增强计划(CEP)和发展研究计划(DRP),以鼓励早期 职业研究者进入转化性 OvCa 研究领域并吸引更多成熟的研究人员 CEP 和 DRP 的研究人员共同承担费用并积极提供服务。 为代表性不足的少数群体的研究人员提供研究经费,将提供潜在的渠道 未来的 SPORE 项目。所有 SPORE、CEP 和 DRP 项目都将接受来自以下机构的财政和科学监督。 一个管理核心和两个共享资源核心的支持。 收集、注释、存档和分发来自 300 多个 HCC 的生物样本和临床数据 每年都会见到 OvCa 患者,它还将开发新的临床前实验模型,其行为更像。 人类 OvCa。生物统计学和生物信息学核心将有助于所有研究的设计和分析,包括 “组学”技术可以提供肿瘤内单个细胞的分子和空间特征。 SPORE 项目还将得到内部和新的合作者的支持 SPORE 项目、CEP、DRP 和核心与我们的外部一起定位。 垂直合作者,以改善卵巢癌患者的结果。 SPORE 将通过进一步合作和未来的非 SPORE 资助来推进。

项目成果

期刊论文数量(0)
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Ronald J Buckanovich其他文献

Phase I and Randomized Phase II Study of Ruxolitinib With Frontline Neoadjuvant Therapy in Advanced Ovarian Cancer: An NRG Oncology Group Study.
Ruxolitinib 联合一线新辅助治疗治疗晚期卵巢癌的 I 期和随机 II 期研究:NRG 肿瘤学小组研究。
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    45.3
  • 作者:
    Charles N Landen;Ronald J Buckanovich;M. Sill;R. Mannel;J. Walker;P. DiSilvestro;Cara Mathews;D. Mutch;Marcia L Hernandez;Lainie P Martin;Erin Bishop;Sarah E Gill;Mary E Gordinier;Robert A. Burger;C. Aghajanian;Joyce F Liu;K. Moore;M. Bookman
  • 通讯作者:
    M. Bookman
Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer.
西地尼布和奥拉帕尼联合用药与奥拉帕尼治疗复发性铂敏感卵巢癌的随机 II 期研究的总生存期和更新的无进展生存期结果。
Activity of cabozantinib (XL184) in advanced ovarian cancer patients (pts): Results from a phase II randomized discontinuation trial (RDT).
卡博替尼 (XL184) 在晚期卵巢癌患者 (pts) 中的活性:II 期随机停药试验 (RDT) 的结果。

Ronald J Buckanovich的其他文献

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{{ truncateString('Ronald J Buckanovich', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10713051
  • 财政年份:
    2023
  • 资助金额:
    $ 216.38万
  • 项目类别:
Project 3: Hedgehog Inhibition to Enhance Response to ICI Therapy
项目 3:Hedgehog 抑制增强 ICI 治疗反应
  • 批准号:
    10713054
  • 财政年份:
    2023
  • 资助金额:
    $ 216.38万
  • 项目类别:
Evaluating unique aspects of quiescent ovarian cancer cell biology for therapeutic targets
评估静息卵巢癌细胞生物学的独特方面以寻找治疗靶点
  • 批准号:
    10750118
  • 财政年份:
    2023
  • 资助金额:
    $ 216.38万
  • 项目类别:
Defining the impact of stromal aging on ovarian cancer initiation
定义基质老化对卵巢癌发生的影响
  • 批准号:
    10353485
  • 财政年份:
    2021
  • 资助金额:
    $ 216.38万
  • 项目类别:
Defining the impact of stromal aging on ovarian cancer initiation
定义基质老化对卵巢癌发生的影响
  • 批准号:
    10491889
  • 财政年份:
    2021
  • 资助金额:
    $ 216.38万
  • 项目类别:
Defining the impact of stromal aging on ovarian cancer initiation
定义基质老化对卵巢癌发生的影响
  • 批准号:
    10659225
  • 财政年份:
    2021
  • 资助金额:
    $ 216.38万
  • 项目类别:
ALDH Inhibition as Modulator of Tumor Immunobiology
ALDH 抑制作为肿瘤免疫生物学的调节剂
  • 批准号:
    10649413
  • 财政年份:
    2020
  • 资助金额:
    $ 216.38万
  • 项目类别:
ALDH Inhibition as Modulator of Tumor Immunobiology
ALDH 抑制作为肿瘤免疫生物学的调节剂
  • 批准号:
    10380368
  • 财政年份:
    2020
  • 资助金额:
    $ 216.38万
  • 项目类别:
ALDH Inhibition as Modulator of Tumor Immunobiology
ALDH 抑制作为肿瘤免疫生物学的调节剂
  • 批准号:
    10524133
  • 财政年份:
    2020
  • 资助金额:
    $ 216.38万
  • 项目类别:
ALDH Inhibition as Modulator of Tumor Immunobiology
ALDH 抑制作为肿瘤免疫生物学的调节剂
  • 批准号:
    10392913
  • 财政年份:
    2020
  • 资助金额:
    $ 216.38万
  • 项目类别:

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生物行为干预可减少 ICD 电击后的 PTSD 症状
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