Consortium of Research Advancement Facilities and Training

研究进步设施和培训联盟

• 批准号: 10594452
• 负责人: Alika Keolaokalani Maunakea
• 金额: $ 32.91万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-20 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594452
• 关键词: Analytical Chemistry; Animals; Area; Basic Science; Berry; Bioinformatics; Biomedical Research; Budgets; Cancer Center; Centers of Research Excellence; Charge; Clinical Research; Collaborations; Collection; Communities; Community Outreach; Complement; Consultations; Contracts; Core Facility; Data; Development; Diet and Nutrition; Doctor of Philosophy; Education; Educational workshop; Ensure; Equipment; Evaluation; Faculty; Food; Fostering; Foundations; Funding; Future; Goals; Grant; Hawaii; Health; Hospitals; Human; Image; Libraries; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Medical; Medical center; Mentors; Metabolic; Metagenomics; Microscopy; Monitor; National Institute on Minority Health and Health Disparities; Nutritional Study; Outcome; Peer Review; Persons; Phenotype; Positioning Attribute; Postdoctoral Fellow; Publications; Quality of life; Reference Standards; Research; Research Activity; Research Personnel; Research Support; Resource Sharing; Resources; Science; Services; Statistical Data Interpretation; Structure; System; Taxus; Technology; Training; Training and Education; Translational Research; Universities; community engagement; cyber infrastructure; data centers; data visualization; design; effectiveness evaluation; epigenomics; flexibility; health disparity; imaging facilities; improved; lipidomics; metabolic phenotype; metabolomics; microbial genomics; microbiome; microscopic imaging; next generation; novel; nutrition; organizational structure; precision nutrition; prisma; recruit; research facility; transcriptomics

SUMMARY/ABSTRACT To enable Precision Nutrition, a Consortium of Research Advancement Facilities & Training (CRAFT) is proposed that will establish new research facilities and enhance existing ones, ensuring that state-of-the- art equipment and other essential resources are available to COBRE-funded researchers to facilitate the conduct of high-quality, high-impact research employing cutting-edge technologies. New, emerging, and established Cores comprising CRAFT that include Epigenomics, Metabolomics, Lipidomics, Microbiomes, Nutrition, Metabolic Phenotyping, Microscopy/Imaging, and Bioinformatics will be integrated under a unified administrative structure, with directors of each Core forming an Executive Committee that facilitates external evaluations and prioritizes budgets annually. This novel configuration of Cores will allow greater resource flexibility and improved efficiency of research. Herein, we propose to establish a new Statistical Analysis, Nutrition & Diet Core, and to expand Epigenomics, Metabolomics, Lipidomics, Metabolic Phenotyping, Microscopy/Imaging, and Bioinformatics Core Facilities. Education, training, access to equipment and consultation are or will be readily available to investigators at the University in each of these areas, through the expertise of highly accomplished faculty and their support staff, postdocs and junior faculty colleagues. The Executive Committee will contract a third-party expert to measure and evaluate the effectiveness of each of the CRAFT Cores annually to ensure relevance and value for UH investigators. The goal of the CRAFT is to provide resources, expertise, education and training for the advancement of meritorious biomedical research provided by the CRAFT will produce the next generation of research leaders and mentors in the field of Precision Nutrition to ultimately benefit the people of Hawaii and the Pacific region through improvement of health outcomes and quality of life. To achieve this goal, we aim to provide access to the latest technologies/equipment (Aim 1), education and training (Aim 2), and consultation-based expertise (Aim 3) altogether supporting research in Epigenomics, Metabolomics, Lipidomics, Metabolic Phenotyping, Metagenomics (Microbiomes), Microscopy/Imaging, and Bioinformatics. Collectively, the availability of the CRAFT resources and expertise will substantively expand the direction and depth of research conducted by researchers and collaborating groups, and increase the quality of their research, thus positioning them to successfully attain high-impact, peer-reviewed publications and external grant support. By working with our Community Engagement and Outreach Core, we anticipate that the research activities in the field of Precision Nutrition will not only be relevant to community needs (e.g., health disparities that are related to deficiencies in nutrition) but also provide a concerted mechanism to encourage community support and education in the area of basic science, clinical, and translational research. Thus, the CRAFT is unique to Hawaii and is an essential foundation for Precision Nutrition with far-reaching implications to health research nationally.

摘要/摘要 为了实现精准营养，研究推进设施和培训联盟 (CRAFT) 成立 提议将建立新的研究设施并加强现有的研究设施，确保最先进的 COBRE 资助的研究人员可以使用艺术设备和其他重要资源来促进研究的进行 采用尖端技术的高质量、高影响力的研究。新的、新兴的和成熟的 CRAFT 的核心包括表观基因组学、代谢组学、脂质组学、微生物组、营养学、 代谢表型、显微镜/成像和生物信息学将整合在一个统一的系统下 行政结构，每个核心的董事组成一个执行委员会，以促进 每年进行外部评估并确定预算的优先顺序。这种新颖的核心配置将允许更大的 资源灵活性和研究效率的提高。在此，我们建议建立一个新的统计体系 分析、营养和饮食核心，并扩展表观基因组学、代谢组学、脂质组学、代谢 表型分析、显微镜/成像和生物信息学核心设施。教育、培训、获得机会 大学的研究人员现在或将来可以随时获得设备和咨询 领域，通过高水平教师及其支持人员、博士后和初级人员的专业知识 教职同事。执行委员会将聘请第三方专家来衡量和评估 每年评估每个 CRAFT 核心的有效性，以确保 UH 研究人员的相关性和价值。 CRAFT 的目标是提供资源、专业知识、教育和培训，以促进 CRAFT 提供的杰出生物医学研究将培养下一代研究领导者 精准营养领域的导师和导师，最终造福夏威夷和太平洋地区的人民 通过改善健康结果和生活质量。为了实现这一目标，我们的目标是提供 最新技术/设备（目标1）、教育和培训（目标2）以及基于咨询的专业知识 （目标 3）共同支持表观基因组学、代谢组学、脂质组学、代谢表型分析的研究， 宏基因组学（微生物组）、显微镜/成像和生物信息学。总的来说，可用性 CRAFT 资源和专业知识将实质性扩展研究的方向和深度 研究人员和合作小组，并提高他们的研究质量，从而使他们能够 成功获得高影响力、同行评审的出版物和外部资助支持。通过与我们合作 社区参与和外展核心，我们预计精密领域的研究活动 营养不仅与社区需求相关（例如，与营养缺乏相关的健康差异） 营养），同时还提供协调一致的机制，鼓励该地区的社区支持和教育 基础科学、临床和转化研究。因此，这种工艺是夏威夷独有的，是必不可少的 精准营养的基础，对全国健康研究产生深远影响。