Combining bioavailability assays with modeling to predict PCBs in fish after reme

将生物利用度测定与建模相结合来预测修复后鱼类中的 PCB

• 批准号: 8514611
• 负责人: Upal Ghosh
• 金额: $ 27.76万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE COUNTY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8514611
• 关键词: Amendment; Biological Assay; Biological Availability; Carbon; Clams; Decision Making; Development; Devices; Diffusion; Ecosystem; Effectiveness; Equilibrium; Exposure to; Fishes; Fluorescence Microscopy; Food Webs; Health; Human; In Situ; Invertebrates; Kinetics; Laboratories; Lead; Link; Measurement; Measures; Methods; Modeling; Motivation; Nature; Organism; Outcome; Pathway interactions; Pesticides; Poison; Polychlorinated Biphenyls; Process; Research; Research Personnel; Research Project Grants; Risk; Rivers; Sampling; Science; Sectioning technique; Site; Superfund; Techniques; Technology; Testing; Time; Translations; Water; Work; base; bioaccumulation; delrin; improved; interest; mathematical model; remediation; research study; uptake

Title: Combining bioavailability assays with modeling to predict PCBs in fish after remediation Project summary Ecological and human health impacts of bioaccumulative contaminants like PCBs are primarily manifested through accumulation of the toxic compounds in higher trophic level organisms like fish that are consumed by humans and top predators in the ecosystem. However, changes in fish are slow to manifest as a consequence of a remedial action and often one has to wait for several years to see such change. To make timely assessments of remediation progress, one alternative is to perform appropriate measurements that indicate changes in key pathways of exposure to fish. Although some advances have been made recently to assess porewater concentrations using passive sampling techniques which respond more rapidly to in-situ remedies, relationship of such measures to accumulation is fish has not been demonstrated. Also, there is a major gap in the development and utilization of fate and biouptake models that can use passive sampling measurements and quantitatively link those measurements to uptake pathways and predict eventual changes in fish concentrations. This proposed research project will refine sampling methods to assess PCB uptake pathways and work with practitioners to incorporate such measures into PCB fate and biouptake models to assess changes in fish concentration over time, and validate the approach through controlled laboratory exposure studies and measurements in the field. The three primary aims of this project are: Specific aim 1: Develop the fundamental basis of passive sampling. This research will use advanced fluorescence microscopy, IR microspectroscopy, and sectioning techniques to directly measure the diffusion of organic molecules in commonly used passive sampler materials (polyethylene, polyoxymethylene, and PDMS). This effort will lead to the selection and use of appropriate polymeric materials for passive equilibrium sampling with much greater confidence about the nature of equilibrium achieved during the exposure period. Specific aim 2: Use passive sampling to measure bioavailability processes and uptake in fish. This research aim will evaluate how sediments amended with activated carbon sorbents in the field impact PCB biouptake in two types of fish through controlled laboratory mesocosm studies and compare with uptake in passive sampling devices developed under Aim 1. Specific aim 3: Incorporate passive sampling inputs to PCB fate and bioaccumulation model. A mathematical model will be developed and used to interpret results from: 1) the mesocosm exposure experiments, and 2) field observations from a PCB-impacted river site to explore the effect of activated carbon treatments on PCB accumulation in fish. Of particular interest is improving the accuracy of model predictions of the benefits of in-situ treatment with activated carbon aimed at reducing pore water concentrations and contaminant bioavailability.

标题：将生物利用性测定与建模相结合以预测在修复后鱼中的PCB 项目摘要 PCB（PCB）的生态和人类健康影响主要是 通过在较高营养水平的生物（如鱼类）中积累的有毒化合物的积累来表现出来 被人类和生态系统中的顶级捕食者消耗。但是，鱼的变化很慢 表现出来是由于采取补救措施的结果，通常必须等待几年才能看到这种情况 改变。为了及时评估补救进度，一种选择是进行适当的 表明暴露于鱼类的关键途径变化的测量值。虽然有些进步有 最近制作了使用被动抽样技术评估孔隙水的浓度 更快地到原位疗法，这种措施与积累的关系不是鱼 证明。此外，命运和生物蛋糕模型的开发和利用也存在一个重大差距 可以使用被动抽样测量并定量将这些测量与吸收联系起来 途径并预测鱼类浓度的最终变化。这个拟议的研究项目将完善 评估PCB摄取途径并与从业者合作以纳入此类方法的方法 衡量PCB命运和Biouptake模型，以评估随着时间的推移而变化，并且 通过对照实验室暴露研究和现场测量来验证该方法。这 该项目的三个主要目的是： 特定目的1：开发被动采样的基本基础。这项研究将使用高级 荧光显微镜，IR显微镜和切片技术直接测量 有机分子在常用的被动采样材料（聚乙烯，聚乙烯， 聚氧甲基和PDM）。这项工作将导致选择和使用适当的聚合物 被动平衡采样的材料，对平衡性质的信心更大得多 在曝光期间实现。 特定目标2：使用被动抽样来测量鱼类的生物利用度过程和吸收。这 研究目的将评估如何在现场用活化的碳吸附剂修改沉积物 PCB Biouptake通过受控实验室中验研究在两种类型的鱼中进行，并与 在AIM 1下开发的被动抽样设备的吸收。 特定目标3：将被动抽样输入纳入PCB命运和生物蓄积模型。一个 数学模型将被开发并用于解释以下的结果：1）中验暴露 实验和2）来自PCB冲击河位的现场观测，以探索激活的效果 鱼类PCB积累的碳处理。特别有趣的是提高模型的准确性 预测旨在减少孔隙水的活性碳原位治疗的益处 浓度和污染物生物利用度。

项目成果

Advancing the Use of Passive Sampling in Risk Assessment and Management of Sediments Contaminated with Hydrophobic Organic Chemicals: Results of an International Ex Situ Passive Sampling Interlaboratory Comparison.

• DOI: 10.1021/acs.est.7b05752
• 发表时间: 2018-03-20
• 期刊: Environmental science & technology
• 影响因子: 11.4
• 作者: Jonker MTO;van der Heijden SA;Adelman D;Apell JN;Burgess RM;Choi Y;Fernandez LA;Flavetta GM;Ghosh U;Gschwend PM;Hale SE;Jalalizadeh M;Khairy M;Lampi MA;Lao W;Lohmann R;Lydy MJ;Maruya KA;Nutile SA;Oen AMP;Rakowska MI;Reible D;Rusina TP;Smedes F;Wu Y
• 通讯作者: Wu Y

Assimilation efficiency of sediment-bound PCBs ingested by fish impacted by strong sorption.

• DOI: 10.1002/etc.3932
• 发表时间: 2017-12
• 期刊: Environmental toxicology and chemistry
• 影响因子: 4.1
• 作者: Fadaei H;Williams E;Place AR;Connolly JP;Ghosh U
• 通讯作者: Ghosh U