Project 5

项目5

• 批准号: 10707458
• 负责人: Timothy Phillips
• 金额: $ 20.19万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707458
• 关键词: Address; Affinity; Air; Amendment; Animals; Area; Binding; Biological; Biological Assay; Biological Availability; Biological Models; Caenorhabditis elegans; Chemical Exposure; Chemicals; Cnidaria; Collaborations; Communities; Competence; Computing Methodologies; Data Analyses; Dermal; Development; Dimensions; Disasters; Drug Metabolic Detoxication; Emergency Situation; Emergency response; Engineering; Ensure; Environment; Environmental Science; Event; Exposure to; Feedback; Food; Food Contamination; Food Supply; Formulation; Frontline worker; Funding; Goals; Hazardous Chemicals; Hazardous Substances; Human; In Vitro; Individual; Ingestion; Inhalation; Inhalation Exposure; Kinetics; Legal patent; Licensing; Life; Masks; Methodology; Methods; Minor; Modeling; Natural Disasters; Neighborhoods; Nematoda; Organism; Outcome; Pathway interactions; Persons; Plants; Play; Pollution; Process; Production; Property; Reaction; Recreation; Research; Research Personnel; Risk; Role; Safety; Sampling; Science; Site; Skin; Soil; Source; Superfund; Surface; Technology; Technology Transfer; Testing; Thermodynamics; Toxic effect; Training; Translational Research; Translations; Vulnerable Populations; Water; Water Supply; Work; absorption; chemical reduction; community engagement; contaminated water; data management; dermal exposure; design; dosimetry; drinking water; efficacy validation; environmental chemical; experience; experimental study; face mask; first responder; in silico; in vivo; in vivo Model; insight; man-made disasters; manufacture; member; molecular dynamics; novel; response; success; superfund site; tool; uptake; vulnerable community

Project 5 ABSTRACT The effects from hazardous substances in the environment can be compounded by their mobilization and redistribution in polluted sediment, soil, water and air following natural disasters and emergencies. Of immediate concern is the safety of safe water and food supplies. Other threats include soil contamination (lawns, community gardens, parks and recreational areas), along with increased risk of human dermal and inhalation exposures near the site of the impact. A major challenge associated with these emergencies is protecting vulnerable communities and neighborhoods, first responders to the disaster, frontline personnel, and those involved in the management and cleanup of the site. Thus, the ability to rapidly minimize hazardous substance effects during disaster events is a critical need. In Aim 1 of this proposal, multicomponent sorbents will be synthesized from diverse materials and compounds that are generally recognized as safe (GRAS), and these sorbents will tightly bind environmental chemicals and design mixtures with high capacity and affinity. The reaction kinetics, thermodynamics and fundamental mechanism(s) involved in interactions between the surfaces of selected sorbent materials and hazardous environmental chemicals and mixtures will be determined using currently available in vitro methods. Computational methods will be used to validate and provide fundamental insights, as well as to predict sorbent properties and screen for optimum GRAS amendments, thus providing feedback and integration with all experiments. Well-established animal and plant organisms that possess a low tolerance for environmental chemicals in water, soil, and sediment will include the Cnidarian model system (Hydra vulgaris), the Lemna minor (duckweed) assay, and the Caenorhabditis elegans nematode assay. These living (in vivo) model systems will be used to predict the toxicity of polluted samples and to validate the efficacy of our selected sorbents and our in vitro and in silico results. In Aim 2, multicomponent sorbents will be developed that will remove hazardous substances from contaminated food, drinking water and soil. Novel barrier formulations will be developed for skin protection and for filter inserts in protective masks to reduce dermal and inhalation exposures to chemicals. In Aim 3, our in vivo models will be used to evaluate real-life environmental samples from disaster sites and well-characterized superfund sites. In these studies, optimal sorbents and levels of inclusion that will result in detoxification of hazardous substances will be determined. Existing collaborations with Community Engagement Core, well-established technology transfer expertise, and interdisciplinary interactions in Project 5 will add an important capability and dimension to the overall Center. The project-to-field pathway for the development of broad-acting sorbents and formulations for hazardous chemicals during the course of our study has been firmly established. We have identified relevant stakeholders and vulnerable communities that will benefit from these products. It is expected that sorbent and barrier technology developed in this research will result in reduced chemical exposures in people and animals during disasters and emergencies.

项目5摘要 环境中有害物质的影响可能会因其动员和 自然灾害和紧急情况下，污染沉积物，土壤，水和空气的再分配。立即 担心的是安全水和食品供应的安全。其他威胁包括土壤污染（草坪，社区 花园，公园和娱乐区），以及人类皮肤和吸入暴露的风险增加 在撞击地点附近。这些紧急情况相关的主要挑战是保护脆弱 社区和社区，急救人员对灾难，一线人员以及参与的人 网站的管理和清理。因此，能够在期间快速最大程度地减少危险物质效应的能力 灾难事件是一个迫切的需求。在本提案的目标1中，将从 通常被认为是安全的材料和化合物（gras），这些吸附剂将紧密 结合具有高容量和亲和力的环境化学品和设计混合物。反应动力学， 参与所选表面之间相互作用的热力学和基本机制 吸附的材料和危险环境化学品和混合物将使用当前确定 可用的体外方法。计算方法将用于验证和提供基本见解，例如 以及预测最佳GRAS修订的吸附于吸附剂的属性和屏幕，从而提供反馈和 与所有实验集成。拥有较低耐受性的动物和植物生物 水，土壤和沉积物中的环境化学物质将包括Cnidarian模型系统（Hydra dulgaris）， Lemna Minor（Duckweed）测定法和秀丽隐杆线虫线虫测定法。这些生活（体内） 模型系统将用于预测污染样品的毒性并验证我们所选的疗效 吸附剂和我们的体外和硅成果。在AIM 2中，将开发多组分吸附剂，将 从受污染的食物，饮用水和土壤中清除有害物质。新颖的障碍配方将 为皮肤保护和防滤器插入保护性口罩以减少皮肤和吸入 暴露于化学物质。在AIM 3中，我们的体内模型将用于评估现实生活中的环境样本 从灾难网站和良好的超级基金网站。在这些研究中，最佳吸附剂和水平 将确定会导致危险物质排毒的包含。现有的合作 社区参与核心，良好的技术转移专业知识和跨学科互动 在项目5中，将为整个中心增加重要的功能和维度。项目到现场的途径 在我们的过程中开发了危险化学物质的广泛作用吸附剂和配方 研究已经牢固确立。我们已经确定了相关的利益相关者和弱势社区 这些产品将受益。预计这项研究中开发的吸附剂和障碍技术将会 在灾难和紧急情况下，人和动物的化学暴露减少。