Project 5

项目5

• 批准号: 10707458
• 负责人: Timothy Phillips
• 金额: $ 20.19万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10707458
• 关键词: Address; Affinity; Air; Amendment; Animals; Area; Binding; Biological; Biological Assay; Biological Availability; Biological Models; Caenorhabditis elegans; Chemical Exposure; Chemicals; Cnidaria; Collaborations; Communities; Competence; Computing Methodologies; Data Analyses; Dermal; Development; Dimensions; Disasters; Drug Metabolic Detoxication; Emergency Situation; Emergency response; Engineering; Ensure; Environment; Environmental Science; Event; Exposure to; Feedback; Food; Food Contamination; Food Supply; Formulation; Frontline worker; Funding; Goals; Hazardous Chemicals; Hazardous Substances; Human; In Vitro; Individual; Ingestion; Inhalation; Inhalation Exposure; Kinetics; Legal patent; Licensing; Life; Masks; Methodology; Methods; Minor; Modeling; Natural Disasters; Neighborhoods; Nematoda; Organism; Outcome; Pathway interactions; Persons; Plants; Play; Pollution; Process; Production; Property; Reaction; Recreation; Research; Research Personnel; Risk; Role; Safety; Sampling; Science; Site; Skin; Soil; Source; Superfund; Surface; Technology; Technology Transfer; Testing; Thermodynamics; Toxic effect; Training; Translational Research; Translations; Vulnerable Populations; Water; Water Supply; Work; absorption; chemical reduction; community engagement; contaminated water; data management; dermal exposure; design; dosimetry; drinking water; efficacy validation; environmental chemical; experience; experimental study; face mask; first responder; in silico; in vivo; in vivo Model; insight; man-made disasters; manufacture; member; molecular dynamics; novel; response; success; superfund site; tool; uptake; vulnerable community

Project 5 ABSTRACT The effects from hazardous substances in the environment can be compounded by their mobilization and redistribution in polluted sediment, soil, water and air following natural disasters and emergencies. Of immediate concern is the safety of safe water and food supplies. Other threats include soil contamination (lawns, community gardens, parks and recreational areas), along with increased risk of human dermal and inhalation exposures near the site of the impact. A major challenge associated with these emergencies is protecting vulnerable communities and neighborhoods, first responders to the disaster, frontline personnel, and those involved in the management and cleanup of the site. Thus, the ability to rapidly minimize hazardous substance effects during disaster events is a critical need. In Aim 1 of this proposal, multicomponent sorbents will be synthesized from diverse materials and compounds that are generally recognized as safe (GRAS), and these sorbents will tightly bind environmental chemicals and design mixtures with high capacity and affinity. The reaction kinetics, thermodynamics and fundamental mechanism(s) involved in interactions between the surfaces of selected sorbent materials and hazardous environmental chemicals and mixtures will be determined using currently available in vitro methods. Computational methods will be used to validate and provide fundamental insights, as well as to predict sorbent properties and screen for optimum GRAS amendments, thus providing feedback and integration with all experiments. Well-established animal and plant organisms that possess a low tolerance for environmental chemicals in water, soil, and sediment will include the Cnidarian model system (Hydra vulgaris), the Lemna minor (duckweed) assay, and the Caenorhabditis elegans nematode assay. These living (in vivo) model systems will be used to predict the toxicity of polluted samples and to validate the efficacy of our selected sorbents and our in vitro and in silico results. In Aim 2, multicomponent sorbents will be developed that will remove hazardous substances from contaminated food, drinking water and soil. Novel barrier formulations will be developed for skin protection and for filter inserts in protective masks to reduce dermal and inhalation exposures to chemicals. In Aim 3, our in vivo models will be used to evaluate real-life environmental samples from disaster sites and well-characterized superfund sites. In these studies, optimal sorbents and levels of inclusion that will result in detoxification of hazardous substances will be determined. Existing collaborations with Community Engagement Core, well-established technology transfer expertise, and interdisciplinary interactions in Project 5 will add an important capability and dimension to the overall Center. The project-to-field pathway for the development of broad-acting sorbents and formulations for hazardous chemicals during the course of our study has been firmly established. We have identified relevant stakeholders and vulnerable communities that will benefit from these products. It is expected that sorbent and barrier technology developed in this research will result in reduced chemical exposures in people and animals during disasters and emergencies.

项目 5 摘要 环境中有害物质的影响可能会因它们的流动和迁移而加剧 自然灾害和紧急情况后污染沉积物、土壤、水和空气的重新分布。即时的 令人担忧的是安全水和食品供应的安全。其他威胁包括土壤污染（草坪、社区 花园、公园和休闲区），同时人体皮肤和吸入暴露的风险增加 靠近撞击地点。与这些紧急情况相关的一个主要挑战是保护弱势群体 社区和邻里、灾难急救人员、一线人员以及参与救灾的人员 现场的管理和清理。因此，能够快速最大限度地减少有害物质的影响 灾难事件是一项迫切需要。在该提案的目标 1 中，多组分吸附剂将由以下物质合成： 多种被普遍认为是安全的材料和化合物（GRAS），并且这些吸附剂将紧密 结合环境化学品并设计具有高容量和亲和力的混合物。反应动力学， 所选表面之间相互作用涉及的热力学和基本机制 吸附剂材料和危险环境化学品和混合物将使用目前确定 可用体外方法。计算方法将用于验证并提供基本见解，例如 以及预测吸附剂特性并筛选最佳 GRAS 修正，从而提供反馈和 与所有实验相结合。成熟的动物和植物有机体具有较低的耐受性 水、土壤和沉积物中的环境化学物质将包括刺胞动物模型系统（Hydra vulgaris）、 浮萍（浮萍）测定和秀丽隐杆线虫线虫测定。这些活体（体内） 模型系统将用于预测污染样品的毒性并验证我们选择的效果 吸附剂以及我们的体外和计算机结果。在目标 2 中，将开发多组分吸附剂， 去除受污染食品、饮用水和土壤中的有害物质。新型屏障配方将 专为皮肤保护和防护面罩中的滤芯而开发，以减少皮肤接触和吸入 接触化学品。在目标 3 中，我们的体内模型将用于评估现实生活中的环境样本 来自灾难现场和特征明确的超级基金地点。在这些研究中，最佳吸附剂和水平 将确定将导致有害物质解毒的纳入。现有合作伙伴 社区参与核心、完善的技术转让专业知识和跨学科互动 项目 5 将为整个中心增添重要的功能和维度。项目到现场的途径 在我们的研究过程中，开发了针对危险化学品的广泛作用的吸附剂和配方 学习已经牢固确立。我们已经确定了相关利益相关者和弱势社区 将从这些产品中受益。预计本研究中开发的吸附剂和阻隔技术将 从而减少灾难和紧急情况期间人和动物接触化学品的情况。