2013 Fibronectin, Integrins & Related Molecules GRC/GRS

2013 纤连蛋白、整合素

• 批准号: 8458354
• 负责人: VALERIE MARIE WEAVER
• 金额: $ 0.12万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-06 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458354
• 关键词: Address; Adhesions; Atherosclerosis; Basic Science; Biological; Blood Platelets; California; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion; Cell Adhesion Process; Cell Differentiation process; Cell Maintenance; Cell Nucleus; Cell-Cell Adhesion; Cell-Matrix Junction; Cells; Cellular Morphology; Clinical Treatment; Collaborations; Complex; Cytoskeleton; Development; Disease; Education; Embryonic Development; Engineering; Extracellular Matrix; Fibronectins; Government; Growth; Health; Homeostasis; Host Defense; Individual; Infection; Inflammatory; Integrins; International; Knowledge; Lead; Leukocyte Trafficking; Life; Link; Malignant Neoplasms; Mechanics; Mediating; Methods; Microscopy; Molecular; Morphogenesis; Myocardial Infarction; Neoplasm Metastasis; Organism; Participant; Physiologic Neovascularization; Postdoctoral Fellow; Property; Reperfusion Injury; Research; Research Personnel; Resistance; Role; Scheme; Scientist; Senior Scientist; Signal Transduction; Site; Solid Neoplasm; Stem cells; Stroke; Structure; Systems Development; Therapeutic; Thrombosis; Thrombus; Tissues; Training; Training and Education; Translating; Treatment Efficacy; Tumor Angiogenesis; United States National Institutes of Health; Vascular blood supply; Vascular remodeling; Wound Healing; abstracting; adhesion receptor; cancer therapy; cell behavior; cell motility; cohort; data exchange; experience; graduate student; human disease; improved; malignant phenotype; mathematical model; meetings; member; migration; neoplastic cell; next generation; novel therapeutic intervention; posters; programs; public health relevance; receptor; symposium; tumor

DESCRIPTION (provided by applicant): We request partial support for the Fibronectin, Integrins and Related Molecules Gordon Research Conference (GRC) and Gordon Research Seminar (GRS). The meetings will be held February 10-15, and February 9-10, 2013 in the Ventura Beach Marriott, Ventura, California, respectively. The broad and long-term objectives of the conference are firstly to increase our understanding of: 1) how interactions between cells and the surrounding extracellular matrices contribute to normal development and homeostasis; 2) how to use this knowledge to obtain a greater understanding and treatment of human diseases, such as cancer and cardiovascular disease; 3) the fundamental molecular mechanisms of cell matrix adhesion, involving complex supramolecular structures extending from the extracellular matrix outside the cell, through transmembrane receptors such as intregrins, to the cytoskeleton and nucleus; 4) how the molecules of the integrin adhesome are especially adapted to respond to and transduce mechanical force. Our second objective is to contribute to the education and training the next generation of scientists. The addition and renewal of the GRS that precedes the GRC provides an exceptional opportunity for graduate students, post- docs, and other scientists with comparable levels of experience and education to discuss their current research with each other and 4 more senior scientists. From past experience it is evident that this scheme strengthens the confidence of the attendees so that they are more active and engaged in the main GRC. The specific aims of this application are to hold a GRS and a GRC that advance the field. The two day GRS will convene 2 invited speakers, 2 discussion leaders with up to 50 graduate student and postdoctoral attendees, 12 of whom will be selected to give talks. The five day GRC that follows will convene 22 invited speakers, with 150 attendees, including the GRS participants, 22 of which will be selected for talks. Both programs will contain poster sessions to further maximize scientific discussions. These meetings seek to advance the field by addressing two challenges shared by many biological fields at present. The first is to integrate robust quantitative analysis, biophysical ad engineering approaches, advanced microscopy and mathematical modeling to enhance our understanding of molecular mechanisms. In particular, it is vital that we bring these approaches to elucidate the special mechano-sensing properties of the integrin adhesion machinery. The second is to use methods to address function within the intact organism, leading the way to a better understanding of how these molecules contribute to development, homeostasis and disease, so that treatments of integrin and ECM related diseases can be improved. We especially seek to understand how mechanical properties of the extracellular matrix and the links to the cytoskeleton have such profound effects on cell behavior.

描述（由申请人提供）：我们要求对纤连蛋白，整合素和相关分子戈登研究会议（GRC）和戈登研究研讨会（GRS）的部分支持。会议将于2月10日至15日举行，并于2013年2月9日至10日在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。会议的广泛和长期目标首先是为了提高我们对：1）细胞与周围细胞外矩阵之间的相互作用如何有助于正常发展和稳态； 2）如何利用这些知识来获得对人类疾病的更了解和治疗，例如癌症和心血管疾病； 3）细胞基质粘附的基本分子机制，涉及复杂的超分子结构，这些结构从细胞外的细胞外基质延伸，通过跨膜受体（例如肾小管素），延伸到细胞骨架和细胞核； 4）整合素的分子如何尤其适应响应和传递机械力。我们的第二个目标是为教育和培训下一代科学家做出贡献。在GRC之前的GRS的加法和续签为研究生，邮政研究生和其他具有可比的经验和教育水平的科学家提供了极好的机会，可以与彼此相互讨论他们当前的研究，还有4位高级科学家。从过去的经验来看，这一计划可以增强与会者的信心，使他们更加活跃并参与主要GRC。本应用程序的具体目的是持有推进该领域的GRS和GRC。为期两天的GRS将召集2名受邀演讲者，2名讨论领导者，最多50名研究生和博士后与会者，其中12名将被选为演讲。接下来的为期五天的GRC将召集22名邀请演讲者，其中150名与会者，包括GRS参与者，其中22名将被选为谈判。这两个程序都将包含海报会议，以进一步最大化科学讨论。这些会议旨在通过解决目前许多生物学领域的两个挑战来推进该领域。首先是整合可靠的定量分析，生物物理AD工程方法，高级显微镜和数学建模，以增强我们对分子机制的理解。特别是，至关重要的是，我们采用这些方法来阐明整联蛋白粘附机制的特殊机械感应特性。第二个是使用方法来解决完整生物体中的功能，从而更好地理解这些分子如何促进发育，稳态和疾病，以便可以改善整合素和ECM相关疾病的治疗方法。我们特别寻求了解细胞外基质的机械性能以及与细胞骨架的联系如何对细胞行为产生如此深远的影响。