Interplay between Intrinsic and extrinsic force and glioma pathogenesis

内在和外在力量与神经胶质瘤发病机制之间的相互作用

基本信息

批准号：
8741085
负责人：
VALERIE MARIE WEAVER
金额：
$ 10.99万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-26 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8741085
关键词：
Address Adhesions Adult Aggressive behavior Angiogenic Factor Behavior Biological Biological Assay Biology Blood Vessels Brain Brain Neoplasms Brain region Cancer Biology Cells Cessation of life Clinical Collagen Confined Spaces Data Deposition Diagnosis Diffusion Environment Extracellular Matrix Fibronectins Figs - dietary Fostering Funding Glioblastoma Glioma Glycocalyx Goals Growth Growth Factor Histology Human Hyaluronic Acid Image In Vitro Individual Inflammation Inflammatory Integrins Intracranial Hypertension Knock-in Mouse Knockout Mice Link Liquid substance Magnetic Resonance Imaging Malignant neoplasm of brain Maps Mechanics Mediating Molecular Mus PTK2 gene Pathogenesis Patient Care Patients Perfusion Phenotype Property Proteins Proteoglycan Radiation therapy Recurrence Request for Proposals Research Resistance Role Sampling Signal Transduction Staging Testing Tissue Procurements Tissues Transgenic Mice Transplantation angiogenesis base brain cell cellular imaging chemokine elastography flexibility improved in vivo interdisciplinary approach interstitial loss of function mortality neoplastic cell nerve stem cell notch protein novel diagnostics novel therapeutics outcome forecast physical science pressure prognostic programs stemness trait tumor

项目摘要

Adult brain cancer continues to be a significant challenge to clinicians and over 20,000 cases are diagnosed per year. Because the prognosis for individuals with glioblastoma, the most common type of brain cancer, remains poor, it is of critical importance that new therapies be developed. This proposal requests funds to support a research program that integrates physical sciences concepts and approaches with basic and clinical cancer biology research strategies to explore the role of cell intrinsic and external force in GBM aggression. The hope is that this interdisciplinary approach will offer a new paradigm with which to clarify the basis for the invasive and treatment resistant phenotype of high grade GBMs, and by so doing reveal new avenues for developing novel diagnostics, prognostics and therapies.

成人脑癌仍然是临床医生的重大挑战，每年被诊断出20,000多例病例。由于胶质母细胞瘤患者的预后（最常见的脑癌类型仍然很差，因此开发新疗法至关重要。该提案要求资金支持一项研究计划，该计划将物理科学概念和方法与基本和临床癌症生物学研究策略相结合，以探索细胞内在和外部力量在GBM侵略中的作用。希望这种跨学科的方法将提供一个新的范式，以阐明高级GBM的侵入性和耐药性表型的基础，并通过这样做揭示了开发新型诊断，预后和疗法的新途径。