2015 Fibronectin, Integrins & Related Molecules Gordon Research Conference & Gordon Research Seminar

2015 纤连蛋白、整合素

• 批准号: 8908601
• 负责人: VALERIE MARIE WEAVER
• 金额: $ 1.92万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8908601
• 关键词: Adhesions; Animal Model; Area; Arthritis; Behavior; Biochemical; Biological Models; Cardiovascular Diseases; Cell Nucleus; Cell-Matrix Junction; Cells; Collaborations; Complex; Cues; Cytoskeleton; Development; Disease; Disease Progression; ECM receptor; Education; Embryonic Development; Engineering; Epithelial-Stromal Communication; Extracellular Matrix; Fibronectins; Fibrosis; Fostering; Government; Homeostasis; Infection; Inflammation; Inflammatory; Integrins; International; Italy; Knowledge; Lead; Life; Malignant Neoplasms; Mechanics; Mentors; Microscopy; Modification; Molecular; Normal tissue morphology; Organism; Participant; Pathology; Postdoctoral Fellow; Process; Property; Regulation; Research; Research Personnel; Resort; Role; Scientist; Signal Transduction; Stem cells; Structure; Therapeutic; Tissue Engineering; Tissues; Training; Training and Education; Translating; Work; Wound Healing; abstracting; biophysical analysis; biophysical properties; career; cell behavior; cohort; data exchange; experience; graduate student; human disease; immune function; insight; mathematical model; meetings; member; next generation; novel therapeutic intervention; novel therapeutics; posters; prevent; programs; public health relevance; receptor; receptor structure function; stem cell fate; symposium; three-dimensional modeling; tissue regeneration

 DESCRIPTION (provided by applicant): We request partial support for the Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar, May 9-15, 2015 at the Il Ciocco Hotel and Resort, Lucca, Italy. The primary objective of the conference is to increase understanding of how biophysical and biochemical cues from the extracellular matrix (ECM) regulate stem cell fate and modulate development and tissue homeostasis and how perturbations in this dialogue promote disease. We aim to delineate how fundamental molecular mechanisms regulating cell matrix adhesion and turnover, are regulated, and to understand how the molecules of the integrin adhesome are adapted to respond to and transduce mechanical force. Our second objective is to foster the careers of junior investigators and contribute to the education and training the next generation of scientists. Inclusion of the Gordon Research Seminar (GRS) preceding the Gordon Research Conference (GRC) provides an opportunity for trainees to present and discuss their research and obtain mentoring from established scientists. This allows valuable networking opportunities, and benefits the main GRC, as the cohort of those who have attended the GRS bring their excitement and enthusiasm to the GRC. The GRS and GRC aim to advance progress in the ECM adhesion area by bringing together diverse cell-ECM researchers and outside experts to share their latest work thereby stimulating new ideas and solving important problems in the field, generating new collaborations, sustaining and expanding the field, and developing new therapeutic opportunities. This will be achieved by convening a 2 day GRS and a 5 day GRC. The GRC includes 2 invited leaders in the field and 12 talks selected from up to 50 participants. The GRC will nucleate around 35 invited speakers that include 16 junior investigators and 10 outside speakers, who represent the cutting edge of current research in ECM adhesion and outside fields, supplemented with 8 selected short talks from the abstracts. Both programs hold poster sessions to maximize scientific discussion. The meetings will advance the field by: 1) integrating robust quantitative analysis, biophysical and engineering approaches, advanced microscopy and mathematical modeling to enhance understanding of molecular mechanisms regulating cell-ECM interactions, and 2) clarifying how ECM context, including biophysical and biochemical properties and dimensionality (3D) modulate cell and tissue fate dynamically focusing on stem cells and tissue development and disease using 3D model systems and organisms. By understanding how cell-ECM interactions regulate cell and tissue fate tissue engineering and regeneration will benefit and treatments aimed at diseases associated with corrupted ECM-receptor interactions will be optimized and new ones identified.

 描述（由适用提供）：我们要求纤连蛋白，整合素和相关分子戈登研究会议和戈登研究研讨会，2015年5月9日至15日在IL Ciocco Hotel and Resort，意大利卢卡市的IL Ciocco Hotel and Resort。会议的主要目的是提高对细胞外基质（ECM）生物物理和生化线索调节干细胞命运的理解，并调节发育和组织体内稳态以及这种对话中的扰动如何促进疾病。我们的目的是描述基本分子机制如何调节细胞基质粘合剂和更新，调节，并了解整联蛋白的分子如何适应以响应和翻译机械力。我们的第二个目标是培养初级调查人员的职业，并为下一代科学家的教育和培训做出贡献。戈登研究会议（GRC）之前的戈登研究研讨会（GRS）为受训者提供了一个机会，可以向学员提供和讨论他们的研究并从既定科学家那里获得心理。这允许有价值的网络机会，并使主要GRC受益，因为参加GRS的人的队列将他们的兴奋和热情带给了GRC。 GRS和GRC的目的是通过将潜水员的细胞ECM研究人员和外部专家汇总在一起，以分享其最新工作，从而刺激新想法并解决该领域的重要问题，创造新的合作，维持和扩展领域，并开发新的治疗机会，从而促进ECM广告领域的进展。这将通过召集2天的GR和5天GRC来实现。 GRC包括该领域的2名受邀领导人，最多50名参与者选择了12个会谈。 GRC将大约有35名受邀演讲者进行核能，其中包括16名初级调查人员和10位外部发言人，这些演讲者代表了ECM粘合剂和外部领域的当前研究的最前沿，并补充了来自摘要的8个精选的简短演讲。这两个程序都举行了海报会议，以最大程度地提高科学讨论。 The meetings will advance the field by: 1) integrating robust quantitative analysis, biophysical and engineering approaches, advanced microscopy and mathematical modeling to enhance Understanding of molecular mechanisms regulating cell-ECM interactions, and 2) clariifying how ECM context, including biophysical and biochemical properties and dimensionality (3D) modulate cell and tissue fate dynamically focusing on stem cells and tissue development and disease using 3D模型系统和组织。通过了解细胞ECM相互作用如何调节细胞和组织命运组织工程和再生将受益，并且将优化针对与ECM受体相互作用损坏的疾病的治疗方法，并确定新的疾病。